Phenyl-substituted sulfonamides

ABSTRACT

This invention relates to novel condensed ring sulfonylureas and their use as herbicides and growth regulants.

This application is a divisional of application U.S. Ser. No.06/911,428, filed Sept. 25, 1986, now U.S. Pat. No. 4,842,639, which isa continuation-in-part of application U.S. Ser. No. 716,351, filed Mar.29, 1985, now abandoned, which in turn is a continuation-in-part ofapplication U.S. Ser. No. 663,555, filed Oct. 22, 1984, now abandonedwhich in turn is a continuation-in-part of application U.S. Ser. No.607,989 filed May 7, 1984, now abandoned.

BACKGROUND OF THE INVENTION

This invention relates to novel condensed ring sulfonylureas and theiruse as herbicides and growth regulants.

U.S. Pat. No. 4,127,405 teaches compounds which are useful forcontrolling weeds in wheat having the formula: ##STR1## wherein R₁ is##STR2## R₃ and R₆ are independently hydrogen, fluorine, chlorine,bromine, iodine, alkyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms,nitro, trifluoromethyl, cyano, CH₃ S(O)_(n) -- or CH₃ CH₂ S(O)_(n) --;

R₄ is hydrogen, fluorine, chlorine, bromine or methyl;

R₅ is hydrogen, fluorine, chlorine, bromine, methyl or methoxy;

R₇ is hydrogen, fluorine, chlorine, bromine, alkyl of 1-2 carbon atomsor alkoxy of 1-2 carbon atoms;

R₈ is hydrogen, methyl, chlorine or bromine;

R₉ and R₁₀ are independently hydrogen, methyl, chlorine or bromine;

W and Q are independently oxygen or sulfur;

n is 0, 1 or 2;

X is hydrogen, chlorine, bromine, methyl, ethyl, alkoxy of 1-3 carbonatoms, trifluoromethyl, CH₃ S-- or CH₃ OCH₂ --; and

Y is methyl or methoxy; or their agriculturally suitable salts; providedthat:

(a) when R₅ is other than hydrogen, at least one of R₃, R₄, R₆ and R₇ isother than hydrogen and at least two of R₃, R₄, R₆ and R₇ must behydrogen;

(b) when R₅ is hydrogen and all of R₃, R₄, R₆ and R₇ are other thanhydrogen, then all of R₃, R₄, R₆ and R₇ must be either chlorine ormethyl; and

(c) when R₃ and R₇ are both hydrogen, at least one of R₄, R₅ or R₆ mustbe hydrogen.

U.S. Pat. No. 4,169,719 discloses herbicidal benezenesulfonylureas.

Herbicidal indanesulfonylureas are taught in U.S. Pat. No. 4,465,506.

Herbicidal quinolinesulfonylureas are described in U.S. Pat. No.4,369,329, issued Jan. 18, 1983.

Herbicidal benzofuran, benzothiophene, benzopyran and benzothiopyransulfonylureas are disclosed in EP-A-79,683, published May 25, 1983.

EP-A-82,681, published June 29, 1983, discloses herbicidal1,3-benzodioxole and 1,4-benzodioxanesulfonylureas.

South African Patent Application 83/5165 discloses herbicidalsulfonylureas of the general structure shown below: ##STR3## wherein Ais an unsubstituted or substituted bridge of 3 or 4 atoms which contains1 or 2 oxygen, sulfur or nitrogen atoms and, together with the linkingcarbon atom, forms a non-aromatic 5- or 6-membered heterocyclic ringsystem, with the proviso that two oxygen atoms are separated by at leastone carbon atom and that oxygen and sulfur atoms are only linked to eachother if the sulfur atom takes the form of the --SO-- or SO₂ -- group.

South African Patent Application 83/7434 discloses herbicidalsulfonamides of formula ##STR4## where Ar is ##STR5## and R₂ is halogen,C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, C₁ -C₃ alkoxy, C₁ -C₃ haloalkoxy, amino,C₁ -C₃ alkylamino, di(C₁ -C₃ alkyl)amino, C₃ -C₆ cycloalkyl or C₂ -C₆alkoxyalkyl.

The presence of undesired vegetation causes substantial damage to usefulcrops, especially agricultural products that satisfy man's basic foodneeds, such as soybeans, barley, wheat, and the like. The currentpopulation explosion and concomitant world food shortage demandimprovements in the efficiency of producing these crops. Prevention orminimizing the loss of a portion of valuable crops by killing, orinhibiting the growth of undesired vegetation is one way of improvingthis efficiency.

A wide variety of materials useful for killing, or inhibiting(controlling) the growth of undesired vegetation is available; suchmaterials are commonly referred to as herbicides. The need exists,however, for still more effective herbicides that destroy or retardweeds without causing significant damage to useful crops.

SUMMARY OF THE INVENTION

This invention relates to novel compounds of Formula I, agriculturallysuitable compositions containing them, and their method-of-use aspreemergent or postemergent herbicides or as plant growth regulants.##STR6## wherein J is ##STR7## n is 0 or 1; W is O or S;

W₁ is S;

W₂ is O or S;

R is H or CH₃ ;

R₁ is H, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, halogen, nitro, C₁ -C₆ alkoxy,SO₂ NR_(a) R_(b), C₁ -C₆ alkylthio, C₁ -C₆ alkylsulfinyl, C₁ -C₆alkylsulfonyl, CN, CO₂ R_(c), C₁ -C₆ haloalkoxy, C₁ -C₆ haloalkylthio,NH₂, C₁ -C₆ alkylamino, di(C₁ -C₆ alkyl)amino, Si(CH₃)₂ (C₁ -C₄ alkyl),Si(CH₃)₂ -phenyl or C₁ -C₃ alkyl substituted with C₁ -C₃ alkoxy, C₁ -C₃alkylthio, C₁ -C₃ alkylsulfinyl, C₁ -C₃ alkylsulfonyl, SO₂ NR_(d) R_(e),NO₂, CN, CO₂ R_(f), C₁ -C₃ haloalkoxy or C₁ -C₃ haloalkylthio;

R_(a) is H, C₁ -C₄ alkyl, C₁ -C₃ cyanoalkyl, methoxy or ethoxy;

R_(b) is H, C₁ -C₄ alkyl or C₃ -C₄ alkenyl; or

R_(a) and R_(b) may be taken together as --(CH₂)₃ --, --(CH₂)₄ --,--(CH₂)₅ -- or --CH₂ CH₂ OCH₂ CH₂ --;

R_(c) is C₁ -C₄ alkyl, C₃ -C₄ alkenyl, C₃ -C₄ alkynyl, C₂ -C₄ haloalkyl,C₂ -C₃ cyanoalkyl, C₅ -C₆ cycloalkyl, C₄ -C₇ cycloalkylalkyl or C₂ -C₄alkoxyalkyl;

R_(d) is C₁ -C₃ alkyl;

R_(e) is H or C₁ -C₃ alkyl;

R_(f) is C₁ -C₃ alkyl;

R₁ ' is H, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, C₁ -C₃ haloalkoxy, C₁ -C₃haloalkyl, C₁ -C₃ alkylthio, C₁ -C₃ haloalkylthio, amino, C₁ -C₃alkylamino, di(C₁ -C₃ alkyl)amino, halogen or NO₂ ;

R₂ is H, R₁₁ ', SR₁₁ ', SO₂ R₁₁, OR₁₁ ', C(O)R₁₁, C(O)OR₁₁ ', (C(O))₂OR₁₁ ', (CO)₂ R₁₁ ', C(O)NR₁₂ R₁₈, C(O)NRA, C(S)SR₁₁ ', NH₂, NR₁₂ R₁₈,OH, CN, P(O)R₁₃ R₁₄, P(S)R₁₃ R₁₄, Si(CH₃)₂ R₁₅, L or C(O)L;

R₃ is H or CH₃ ;

R₄ is C₁ -C₄ alkyl;

R₅ is H or C₁ -C₄ alkyl;

R₆ is H or CH₃ ;

R₇ is C₁ -C₄ alkyl, Cl or Br;

A is ##STR8## X is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁-C₄ haloalkyl, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, F, Cl, Br, C₂ -C₅alkoxyalkyl, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino, amino, di(C₁-C₃ alkyl)amino or C₃ -C₅ cycloalkyl;

Y is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄haloalkylthio, C₁ -C₄ alkylthio, C₂ -C₅ alkoxyalkyl, C₂ -C₅alkoxyalkoxy, amino, C₁ -C₃ alkylamino, di(C₁ -C₃ alkyl)amino, C₃ -C₄alkenyloxy, C₃ -C₄ alkynyloxy, C₂ -C₅ alkylthioalkyl, C₁ -C₄ haloalkyl,azido, cyano, ##STR9## or N(OCH₃)CH₃ ; m is 2 or 3;

Q₁ and Q₂ are independently O or S;

R₈ is H or C₁ -C₃ alkyl;

R₉ and R₁₀ are independently C₁ -C₃ alkyl;

Z is CH, N, CCH₃, CC₂ H₅, CCl or CBr;

Y₁ is O or CH₂ ;

X₁ is CH₃, OCH₃, OC₂ H₅ or OCF₂ H;

X₂ is CH₃, C₂ H₅ or CH₂ CF₃ ;

Y₂ is OCH₃, OC₂ H₅, SCH₃, SC₂ H₅, CH₃ or CH₂ CH₃ ;

X₃ is CH₃ or OCH₃ ;

Y₃ is H or CH₃ ;

Y₄ is CH₃, OCH₃, OC₂ H₅ or Cl;

X₄ is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃ or Cl;

R₁₁ is C₁ -C₁₀ alkyl, C₃ -C₁₀ alkoxyalkoxyalkyl, C₂ -C₁₀ alkenyl, C₄-C₁₀ alkenylalkenyl, C₃ -C₁₀ epoxyalkyl, C₂ -C₁₀ alkynyl, C₄ -C₁₀alkynylalkynyl, C₄ -C₁₀ alkynylalkenyl, C₃ -C₆ cycloalkyl, C₄ -C₇cycloalkylalkyl or ##STR10## when R₁₁ is C₃ -C₆ cycloalkyl or C₄ -C₇cycloalkylalkyl it may optionally be substituted by C₁ -C₄ alkyl, 1 to 3atoms of Cl or F or 1 Br; when R₁₁ is C₁ -C₁₀ alkyl, C₂ -C₁₀ alkenyl orC₂ -C₁₀ alkynyl it may optionally be substituted by one or more halogensand/or by (R₁₇)_(m) ', where when m' is 2, the values of R₁₇ may beidentical or different;

R₁₁ ' is C₁ -C₁₀ alkyl, C₃ -C₁₀ alkoxyalkoxyalkyl, C₃ -C₁₀ alkenyl, C₅-C₁₀ alkenylalkenyl, C₃ -C₁₀ epoxyalkyl, C₃ -C₁₀ alkynyl, C₅ -C₁₀alkynylalkynyl, C₅ -C₁₀ alkynylalkenyl, C₃ -C₆ cycloalkyl, C₄ -C₇cycloalkylalkyl or ##STR11## when R₁ ' is C₃ -C₆ cycloalkyl or C₄ -C₇cycloalkylalkyl it may be optionally substituted by C₁ -C₄ alkyl, 1 to 3atoms of Cl or F or 1Br; when R₁₁ ' is C₁ -C₁₀ alkyl, C₃ -C₁₀ alkenyl orC₃ -C₁₀ alkynyl, it may optionally be substituted by one or morehalogens and/or by (R₁₇)_(m) ', where when m' is 2, the values of R₁₇may be identical or different;

m' is 1 or 2;

R₁₂ is H or C₁ -C₄ alkyl;

R₁₃ and R₁₄ are independently C₁ -C₄ alkyl, C₁ -C₄ alkoxy or C₁ -C₄alkylthio;

R₁₅ is C₁ -C₁₀ alkyl, benzyl or ##STR12## R₁₆ is H, F, Cl, Br, CH₃,OCH₃, NO₂, CN, SCH₃, SO₂ CH₃ or CF₃ ;

R₁₇ is OR₁₈, OC(O)R₁₈, P+R₉ R₁₀ R₁₅, P+(C₆ H₅)₃, OC(O)NR₁₂ R₁₈, OSO₂ R₁₈', OP(O)R₁₃ R₁₄, P(O)R₁₃ R₁₄ OP(S)R₁₃ R₁₄, P(S)R₁₃ R₁₄, OSi(CH₃)₂ R₁₅,Si(CH₃)₂ R₁₅, SR₁₈, SOR₁₈ ', SO₂ R₁₈ ', SCN, CN, SP(O)R₁₃ R₁₄, SP(S)R₁₃R₁₄, N⁺ R₁₂ R₁₅ R₁₈, NR₁₂ R₁₈, NR₁₂ C(O)R₁₈, NR₁₂ C(O)OR₁₈ ', NR₁₂C(O)NR₁₂ R₁₈, NR₁₂ SO₂ R₁₈ ', NR₁₂ P(O)R₁₃ R₁₄, NR₁₂ P(S)R₁₃ R₁₄, NO₂,C(O)R₁₈, C(O)OR₁₈, C(O)NR₁₂ R₁₈, SeR₁₈, naphthyl, L, ##STR13## R₁₈ is H,C₁ -C₁₀ alkyl, C₁ -C₁₀ haloalkyl, C₂ -C₁₀ alkenyl, C₂ -C₁₀ alkynyl, C₃-C₆ cycloalkyl or ##STR14## R₁₈ ' is C₁ -C₁₀ alkyl, C₁ -C₁₀ haloalkyl,C₃ -C₁₀ alkenyl, C₃ -C₁₀ alkynyl, C₃ -C₆ cycloalkyl or ##STR15## R₁₉ isH, F, Cl, Br, CH₃, ##STR16## and L is a 5- or 6-membered aromaticheterocycle, a 5- or 6-membered dihydroaromatic heterocycle or a 5- or6-membered tetrahydroaromatic heterocycle which contains 1-4 heteroatomsselected from 0-1 oxygen atoms, 0-1 sulfur atoms wherein sulfur may takethe form of S, SO or SO₂, and/or 0-4 nitrogen atoms, with the provisothat oxygen and sulfur are only linked to each other if the sulfur is inthe form of SO or SO₂, and these heterocycles may optionally besubstituted by 1-4 CH₃, 1-2 OCH₃, SCH₃, Cl, N(CH₃)₂ or CN or L is a 5-or 6-membered lactone, lactam or cycloalkanone which may optionally besubstituted by 1-4 CH₃ groups;

provided that

(a) when W is S, then R is H, J is J₁, J₂, J₃ or J₄ ; A is A-1, Z is CHor N, and Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, CF₃, SCH₃, OCH₂CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CF₃, OCH₂ CH₂ OCH₃, CH(OCH₃)₂ or ##STR17##(b) when X is F, Cl or Br, then Z is CH and Y is OCH₃, OC₂ H₅, NH₂,NHCH₃, N(CH₃)₂ or OCF₂ H;

(c) when R₃ is CH₃, then n is O;

(d) when J is J-1 or J-2 and R₂ is H or C₁ -C₄ alkyl, then R₁ and R₁ 'are other than H, F, Cl, Br, CH₃, OCH₃, CF₃, OCF₂ H, or SCH₃ or X isother than CH₃, OCH₃, OCH₂ CH₃, F, Cl, Br, OCF₂ H, CH₂ Cl, CH₂ Br, CH₂F, cyclopropyl or CF₃ or Y is C₃ -C₄ alkyl, C₃ -C₄ alkoxy, C₄haloalkoxy, C₄ haloalkylthio, C₃ -C₅ alkoxyalkyl, C₄ -C₅ alkoxyalkoxy,C₂ -C₃ alkylamino, di(C₂ -C₃ alkyl)amino, C₄ alkenyloxy, C₄ alkynyloxy,C₃ -C₅ alkylthioalkyl, C₂ -C₄ haloalkyl, C₂ -C₄ alkynyl, C(O)R₈ orN(OCH₃)CH₃ ;

(e) the total number of carbon atoms in R₂ does not exceed 13;

(f) when X is C₃ -C₅ cycloalkyl, then Y is CH₃, CH₂ CH₃, OCH₃, OCH₂ CH₃,CH₂ OCH₃, OCF₂ H, SCF₂ H, OCH₂ CF₃, CF₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH,NHCH₃, N(CH₃)₂ or CH(OCH₃)₂ ;

(g) when R₁ or R₁ ' is para to the sulfonylurea bridge then R₁ or R₁ 'are H, CH₃, F, Cl, Br or OCH₃ ; and

(h) when X or Y is OCH₂ CH₂ F or OCH₂ CHF₂ then R₂ is other than C₅alkyl, CH₃ OCH₂ CH₂, C₂ H₅ OCH₂ CH₂ or C₁ -C₄ alkyl substituted with 1-3atoms of F, Cl or Br;

(i) when X is Y is OCH₂ CH₂ F, OCH₂ CHF₂ or OCH₂ CF₃, then the other isnot di(C₁ -C₃ alkyl)amino C₁ -C₃ alkylamino or N(OCH₃)CH₃ ;

(j) when X or Y is OCF₂ H, then Z is CH;

(k) when R₁₇ and the bridging nitrogen of a cyclic sulfonamide areattached to the same carbon, then R₁₇ is other than OH, SH, OC(O)R₁₈,OC(O)NR₁₂ R₁₈, OSO₂ R₁₈ ', OP(O)R₁₃ R₁₄, OSi(CH₃)₂ R₁₅, SP(O)R₁₃ R₁₄,SP(S)R₁₃ R₁₄, NR₁₂ R₁₈ or N+R₁₂ R₁₅ R₁₈ ;

and their agriculturally suitable salts.

In the above definitions, the term "alkyl", used either alone or incompound words such as "alkylthio" or "haloalkyl", denotes straightchain or branched alkyl, e.g. methyl, ethyl, n-propyl, 2-propyl or thedifferent butyl, pentyl, hexyl, heptyl, octyl, nonyl or decyl isomers.

Alkoxy denotes methoxy, ethoxy, n-propyloxy, isopropyloxy and thedifferent butyl, pentyl or hexyl isomers.

Alkenyl denotes straight chain or branched alkenes, e.g. vinyl,1-propenyl, 2-propenyl, isopropenyl and the different butenyl, pentenyl,hexenyl, heptenyl, ocetenyl, nonenyl or decenyl isomers.

Alkynyl denotes straight chain or branched alkynes, e.g. ethynyl,1-propynyl, 2-propynyl and the different butynyl, pentynyl, hexynyl,heptynyl, octynyl, nonynyl and decynyl isomers.

Alkylsulfonyl denotes methylsulfonyl, ethylsulfonyl and the differentpropylsulfonyl isomers.

Alkylthio, alkylsulfinyl, alkylamino, alkylsulfamoyl, etc. are definedanalogously to the above examples.

Cycloalkyl denotes cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.

The term "halogen", either alone or in compound words such as"haloalkyl", denotes fluorine, chlorine, bromine or iodine.

The total number of carbon atoms in a substituent group is indicated bythe C_(i) -C_(j) prefix where i and j are numbers from 1 to 10. Forexample, C₃ -C₅ alkylthioalkyl would designate CH₂ SCH₂ CH₃ through(CH₂)₄ SCH₃ or CH₂ SC₄ H₉, C₂ alkoxyalkoxy would designate OCH₂ OCH₃, C₂cyanoalkyl would designate CH₂ CN and C₃ cyanoalkyl would designate CH₂CH₂ CN and CH(CN)CH₃.

It would be recognized by one skilled in the art that when R₁₇ is OH orSH, that these substituents cannot be bonded to the same carbon asanother heteroatom or to an olefinic or acetylenic carbon atom.

Preferred for reasons of their higher herbicidal activity, greater plantgrowth regulant activity or more favorable ease of synthesis are:

1. Compounds of Formula I wherein J is J-1 or J-4.

2. Compounds of Formula I wherein J is J-2 or J-3.

3. Compounds of Formula I wherein J is J-8 or J-9.

4. Compounds of Formula I wherein J is J-5, J-6, J-7 or J-10.

5. Compounds of Formula I wherein J is J-11 or J-12.

6. Compounds of Preferred 1 wherein

W is O;

R is H;

X is CH₃, OCH₃, OCH₂ CH₃, Cl, F, Br, OCF₂ H, CH₂ F, CF₃ or cyclopropyl;

Y is H, CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, NH₂, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂, C₂H₅, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CF₃, CN, N₃, OCH₂ CH₂OCH₃, CH₂ SCH₃, ##STR18## or QCF₂ T; Q is O or S;

T is H, CHClF CHBrF or CHFCF₃.

7. Compounds of Preferred 6 wherein R₁ is C₁ -C₃ alkyl, C₁ -C₃ alkoxy,C₁ -C₃ haloalkoxy, C₁ -C₃ haloalkyl, C₁ -C₃ alkylthio, C₁ -C₃haloalkylthio, amino, C₁ -C₃ alkylsulfinyl, C₁ -C₃ alkylsulfonyl, CN,NH₂, C₁ -C₃ alkylamino, di(C₁ -C₃ alkylamino) or C₁ -C₂ alkylsubstituted with C₁ -C₂ alkoxy, C₁ -C₂ alkylthio, C₁ -C₂ haloalkoxy, C₁-C₂ haloalkylthio, CN or NO₂.

8. Compounds of Preferred 7 wherein

R₂ is C₁ -C₆ alkyl, C₁ -C₆ alkylcarbonyl, C₁ -C₆ alkoxycarbonyl, C₁ -C₆alkyl substituted by 1-3 atoms of F, Cl or 1 Br, or by 1 or 2 groupsselected from C₁ -C₂ alkoxy, CN, C₁ -C₂ alkoxycarbonyl, C₁ -C₂alkylcarbonyl, OH, C₁ -C₂ alkylthio C₁ -C₂ alkylsulfonyl, C₁ -C₂alkylsulfonyloxy or C₁ -C₂ alkylcarbonyloxy, C₃ -C₄ alkenyl, C₃ -C₄haloalkenyl, C₃ -C₄ alkynyl, C₄ alkynyl substituted by 1 atom of F orCl, phenyl or phenyl substituted with Cl, CF₃, NO₂, CN or SO₂ CH₃ ; and

R₄ is CH₃.

9. Compounds of Preferred 8 wherein

A is A-1; and

Y is CH₃, C₂ H₅, OCH₃, CH₂ OCH₃, OCF₂ H or CH(OCH₃)₂.

10. Compounds of Preferred 9 wherein R₁ and R₁ ' are H, Cl, C₁ -C₂alkyl, C₁ -C₂ alkoxy or C₁ -C₂ alkylthio.

11. Compounds of Preferred 10 wherein J is J-1.

12. Compounds of Preferred 11 wherein

R₁ is H; and

Z is CH.

13. Compounds of Preferred 12 wherein R₂ is C₁ -C₄ haloalkyl, C₁ -C₃alkyl substituted with C₁ -C₂ alkoxy, C₁ -C₂ alkylthio, C₁ -C₂alkylsulfonyl or CN, C₃ -C₄ alkenyl, C₃ -C₄ haloalkenyl, C₃ -C₄ alkynyl,C₁ -C₃ alkoxycarbonyl or C₁ -C₃ alkylcarbonyl.

14. Compounds of Preferred 11 wherein

R₁ is H;

Z is N; and

R₂ is C₁ -C₃ alkylcarbonyl or C₁ -C₃ alkoxycarbonyl.

15. Compounds of Preferred 2 wherein

W is O;

R₁ is H;

X is CH₃, OCH₃, OCH₂ CH₃, Cl, F, Br, OCF₂ H, CH₂ F, CF₃ or cyclopropyl;

Y is H, CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, NH₂, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂, C₂H₅, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CF₃, CN, N₃, OCH₂ CH₂OCH₃, CH₂ SCH₃, ##STR19## or QCF₂ T; R₂ is C₁ -C₆ alkyl, C₁ -C₆alkylcarbonyl, C₁ -C₆ alkoxycarbonyl, C₁ -C₆ alkyl substituted by 1-3atoms of F, Cl or 1 Br, or by 1 or 2 groups selected from C₁ -C₂ alkoxy,CN, C₁ -C₂ alkoxycarbonyl, C₁ -C₂ alkylcarbonyl, OH, C₁ -C₂ alkylthio C₁-C₂ alkylsulfonyl, C₁ -C₂ alkylsulfonyloxy or C₁ -C₂ alkylcarbonyloxy,C₃ -C₄ alkenyl, C₃ -C₄ haloalkenyl, C₃ -C₄ alkynyl, C₄ alkynylsubstituted by 1 atom of F or Cl, phenyl or phenyl substituted with Cl,CF₃, NO₂, CN or SO₂ CH₃ ;

R₁ ' is H, Cl, C₁ -C₂ alkyl, C₁ -C₂ alkoxy or C₁ -C₂ alkylthio.

16. Compounds of Preferred 15 wherein

A is A-1; and

Y is CH₃, C₂ H₅, OCH₃, CH₂ OCH₃, OCF₂ H or CH(OCH₃)₂.

17. Compounds of Preferred 3 wherein

W is O;

R₁ is H;

R₁ ' is H;

A is A-1;

X is CH₃, OCH₃, OCH₂ CH₃, Cl, F, Br, OCF₂ H, CH₂ F or cyclopropyl; and

Y is CH₃, C₂ H₅, OCH₃, CH₂ OCH₃, OCF₂ H or CH(OCH₃)₂ ;

18. Compounds of Preferred 4 wherein

W is O;

R₁ is H;

R₁ ' is H;

A is A-1;

X is CH₃, OCH₃, OCH₂ CH₃, Cl, F, Br, OCF₂ H, CH₂ F or cyclopropyl; and

Y is CH₃, C₂ H₅, OCH₃, CH₂ OCH₃, OCF₂ H or CH(OCH₃)₂ ;

19. Compounds of Preferred 5 wherein

W is O;

R₁ is H;

R₁ ' is H;

A is A-1;

X is CH₃, OCH₃, OCH₂ CH₃, Cl, F, Br, OCF₂ H, CH₂ F or cyclopropyl; and

Y is CH₃, C₂ H₅, OCH₃, CH₂ OCH₃, OCF₂ H or CH(OCH₃)₂.

Specifically preferred for reasons of their highest herbicidal activity,greatest plant growth regulant activity and/or most favorable ease ofsynthesis are:

2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(2-methoxyethyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide, m.p. 194°-197° C.;

2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(3-methylbutyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide, m.p. 227°-229° C.;

2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(phenylmethyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide, m.p. 216°-218° C.;

2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(2-oxopropyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide, m.p. 178°-182° C.;

2,3-dihydro-N-[(4-chloro-6-methoxypyrimidin-2-yl)aminocarbonyl]-2-(2-ethoxyethyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide, m.p. 193°-197° C.;

2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(2-ethoxyethyl)-1,2-benzisothiazole-7-sulfonamide,1-1-dioxide, m.p. 203°-204° C.;

2,3-dihydro-N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-2-(2-fluoroethyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide, m.p. 214°-215° C.;

2,3-dihydro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-(2-fluoroethyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide, m.p. 190°-192° C.;

2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-acetyl-1,2-benzoisothiazole-7-sulfonamide,1,1-dioxide, m.p. 191°-193° C.;

2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(3-chloropropyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide, m.p. 201°-203° C.;

2,3-dihydro-N-[(chloro-6-methoxypyrimidin-2-yl)aminocarbonyl]-2-(2-fluoroethyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide, m.p. 215°-217° C.;

2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(3-fluoropropyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide, m.p. 199°-200° C.;

2,3-dihydro-N-[(4-chloro-6-methoxypyrimidin-2-yl)aminocarbonyl]-2-(2-chloroethyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide, m.p. 219°-220° C.;

N-[(4-chloro-6-methoxypyrimidin-2-yl)aminocarbonyl]-2-(2-fluoroethyl)-2,3-dihydro-1,2-benzoisothiazole-7-sulfonamide,1,1-dioxide, m.p. 215°-217° C.;

N-[(4-chloro-6-methoxypyrimidin-2-yl)aminocarbonyl]-2-(3-fluoropropyl)-2,3-dihydro-1,2-benzoisothiazole-7-sulfonamide,1,1-dioxide, m.p. 222.5°-223.5° C.

DETAILED DESCRIPTION OF THE INVENTION Synthesis

The following discussion represents a general outline for thepreparation of the compounds of this invention. All of the synthesesdescribed below are multistep with one or more methods being taught foreach step. This allows for a wide variety of possible synthetic pathwaysto prepare a particular compound of Formula I. The proper choice of thesynthetic pathway and the best ordering of the reaction sequences foreach individual compound will be known to one skilled in the art.

The compounds of Formula I can be prepared by one or more of the methodsdescribed below in Equations 1 through 5.

As shown in Equation 1, many of the compounds of Formula I, where J isJ₁, J₂, J₃ and J₄, can be prepared by reacting a sulfonylisocyanate(W=O) or, a sulfonylisothiocyanate (W=S) of Formula II with anappropriate heterocyclic amine of Formula III. R, A and W are aspreviously defined. ##STR20##

The reaction is carried out at 25° to 100° C. in an inert, aproticsolvent such as methylene chloride or xylene for 0.5 to 24 hours astaught in U.S. Pat. No. 4,127,405.

Many of the compounds of Formula I, where J is J₁, J₂, J₃ and J₄, W is Sand R is H, (Ia) can be prepared by reacting the appropriate sulfonamideof Formula IV with a heterocyclic isothiocyanate of Formula V, as shownin Equation 2. ##STR21##

The reaction is carried out at 25° to 80° C. in an inert, aproticsolvent such as acetone or acetonitrile in the presence of a base suchas potassium carbonate for 0.5 to 24 hours. The required heterocyclicisothiocyanates V are prepared from the corresponding amines III whichwould be known to one skilled in the art as taught in EPO Publication35,893.

Many of the compounds of Formula I, where J is J₁, J₂, J₃ and J₄ and Wis O (Ib), can be prepared by reacting a sulfonylcarbamate of Formula VIwith an appropriate amine of Formula III, as shown in Equation 3.##STR22##

The reaction is carried out at 50° to 100° C. in a solvent such asdioxane for 0.5 to 24 hours. The required carbamates VII are prepared byreacting the corresponding sulfonamides IV with diphenylcarbonate in thepresence of a strong base.

Compounds of Formula Ib can also be prepared, as shown in Equation 4, byreacting a heterocyclic carbamate of Formula VII with an appropriatesulfonamide of Formula IV. ##STR23##

The reaction is carried out at 0° to 50° C. in a solvent such asacetonitrile or dioxane in the presence of a non-nucleophilic base suchas DBU for 0.2 to 24 hours. The required phenylcarbamate VII areprepared by reacting the corresponding heterocyclic amines III withdiphenylcarbonate or phenylchloroformate in the presence of a strongbase.

Many of the compounds of Formula Ib where J is J₁, J₂, J₃ and J₄ can beprepared by reacting the sulfonamides of Formula IV with an appropriatemethylcarbamate of Formula VIII in the presence of an equimolar amountof trimethylaluminum, as shown in Equation 5. ##STR24##

The reaction is carried out at 25° to 40° C. in a solvent such asmethylene chloride for 10 to 96 hours under an inert atmosphere. Therequired carbamates VIII are prepared by reacting the correspondingamines III with dimethylcarbonate or methyl chloroformate in thepresence of a strong base.

The intermediate sulfonylisocyanates (W=O) and sulfonylisothiocyanates(W=S) of Formula II from Equation 1 can be prepared as shown inEquations 4 through 8.

As shown in Equation 6, many of the sulfonylisocyanates of Formula IIawhere J is J₁, J₂, J₃ and J₄ can be prepared by the reaction ofsulfonamides of Formula IV with phosgene, in the presence ofn-butylisocyanate and a tertiary amine catalyst, at reflux in a solventsuch as xylene by the method of U.S. Pat. No. 4,238,621. ##STR25##

The sulfonylisocyanates can also be prepared from the sulfonamides by atwo step procedure involving (a) reacting the sulfonamides withn-butylisocyanate in the presence of a base such as K₂ CO₃ at reflux inan inert solvent such as 2-butanone forming a n-butylsulfonylurea; and(b) reacting this compound with phosgene and a tertiary amine catalystat reflux in xylene solvent. The method is similar to a procedure taughtby Ulrich and Sayigh, Newer Methods of Preparative Organic Chemistry,Vol. VI, p. 223-241, Academic Press, New York and London, W. Foerst Ed.

Alternatively, as shown in Equation 7, many of the sulfonylisocyanatesof Formula IIa where J is J₁, J₂, J₃ and J₄ can be prepared by reactingthe corresponding sulfonyl chlorides IX with cyanic acid salts.##STR26##

The reaction is carried out at 25° to 100° C. in an inert aproticsolvent such as acetonitrile for 0.5-24 hours in the presence ofphosphorus pentoxide and an alkali metal salt such as lithium iodide.

Many of the sulfonylisothiocyanates of Formula IIb where J is J₁, J₂, J₃and J₄ can be prepared, as shown in Equation 8, by contacting thesulfonamides of Formula IV with carbon disulfide in the presence of twoequivalents of a strong base. The resulting salt is then reacted withphosgene according to the teachings of K. Hartke, Arch. Pharm., 299, 174(1966). ##STR27##

The sulfonamides of Formula IV where J is J₁, J₂, J₃ and J₄ of Equations2, 4, 5, 6 and 8 as well as the other sulfonamides required to preparethe compounds of this invention can be prepared from the correspondingsulfonyl chlorides of Formula IX by contacting with either anhydrous oraqueous ammonia as shown in Equation 9. ##STR28##

The preparation of sulfonamides from sulfonyl chlorides is widelyreported in the literature, for reviews see: F. Hawking and J. S.Lawrence, "The Sulfonamides," H. K. Lewis and Co., London, 1950 and E.H. Northey, "The Sulfonamides and Allied Compounds," Reinhold PublishingCorp., New York, 1948.

Alternatively, many sulfonamides IV can be prepared by dealkylation oftheir corresponding N-t-butyl sulfonamides X as shown in Equation 10.##STR29##

The reaction is carried out by contacting the N-t-butyl sulfonamide Xwith a strong acid such as trifluoroacetic acid or methanolic HCl at 25°to 50° C. for 0.5 to 24 hours. The N-t-butyl sulfonamides X are readilyprepared by reacting sulfonylchlorides IX with t-butylamine and areuseful either as an aid in purification, to enhance solubility forsubsequent reactions such as Equation 12 below or to protect thesulfonamide function from competing with reactions at other parts of themolecule.

Many of the sulfonamides of Formula IVa can be prepared byfunctionalization of the corresponding N-unsubstituted sulfonamides ofFormula IVb as shown in Equation 11. G₁ -G₂ is CHR₃ (CHR₄)_(n) andCH═CR₄, R' is H or C(CH₃)₃ and X is Cl, Br, I or other readilydisplaceable groups. When R₃ is CH₃ then is 0. ##STR30##

The reaction is carried out by contacting the sulfonamides IVb with theappropriate electrophile in the presence of a suitable base such as K₂CO₃ in an inert, polar solvent such as DMF at 0° to 100° C. for 0.5 to24 hours. In some instances the R₂ function can also be introduced byMichael addition of IVb to the appropriate Michael acceptor as known toone skilled in the art.

While many of the R₂ groups can be introduced directly, as describedabove, some of the R₂ groups may best be prepared by standard functionalgroup manipulations upon compounds of Formula IVa containing anappropriate R₂ group pecursor as will be known to one skilled in theart. Some examples of these manipulations are the preparation of IVawhere R₂ contains an epoxide by the epoxidation of IVa where R₂ containsa carbon-carbon double bond, the preparation of IVa where R₂ contains asulfone by the oxidation of IVa where R₂ contains a thioether function,the preparation of IVa where R₂ contains OC(O)CH₃ by acetylation of IVawhere R₂ contains OH, or the preparation of IVa where R₂ contains NH₂ bythe reduction of IVa where R₂ contains NO₂. This is also the case formany of the R₁ substituents which can be prepared by an analogouschemical manipulation known to one skilled in the art.

Many of the unsaturated sulfonamides of Formula IVc can also be preparedfrom the corresponding saturated sulfonamides of Formula IVd by thetwo-step procedure shown in Equation 12. G₁ -G₂ is SO₂ --NR₂, CO--NR₅ orNR₅ --CO, R' is H or C(CH₃)₃ and R" is H or R₄. ##STR31##

The first step involves benzylic bromination by N-bromosuccinimide togive a monobromide which is subsequently dehydrobrominated in a secondstep by reaction with a suitable base such as triethyl amine orpotassium-t-butoxide in an inert solvent such as THF. This method hasbeen used to prepare isocoumarins from 3,4-dihydroisocoumarins, see R.Barry, Chem. Rev., 64, 229 (1964). In cases where R₁ is an alkyl group,competitive bromination at this site may occur resulting in a mixture.The desired bromide may be separated at this stage, or after treatmentwith the base, by standard methods.

The thiocarbonylsulfonamides of Formula IV where J is J₅, J₆, J₇, J₈, J₉and J₁₀ and where W₁ is S can be prepared from their correspondingoxygen analogs where W₁ is O as represented in Equation 13 using ringsystem J₅ as an example. ##STR32##

The reaction is carried out at 100° to 140° C. in a solvent such asxylene for 1.0 to 24 hours as taught by Lawesson, et al. Bull. Chem.Soc. Belg., 87, 229 (1978). The corresponding oxygen carbonylsulfonamides of ring systems J₅, J₆, J₇, J₈, J₉ and J₁₀ where W₁ is Ocan be prepared according to the methods described herein and in EPOPublication No. 107979. EPO Publication No. 107979 also describes thesynthesis of indanone and tetralone sulfonamides which can be ketalizedby standard methods known to one skilled in the art to give sulfonamidesof Formula IV where J is J-11 and J-12.

The sulfonyl chlorides of Formula IX of Equations 7 and 9 are importantintermediates for the preparation of the compounds of this invention.The syntheses of the required sulfonyl chloride intermediates where J isJ₁, J₂, J₃ and J₄ are described in Equations 14 through 16. Thesemethods can also be used to prepare the corresponding oxygen carbonylanalogs of ring systems J₅, J₆, J₇, J₈, J₉ and J₁₀ where W₁ is O.

As shown in Equation 14, many of the sulfonyl chlorides of Formula IXcan be prepared from the corresponding amines XI. ##STR33##

The reaction involves diazotization of the amine XI with sodium nitritein HCl, followed by reaction of the diazonium salt with sulfur dioxideand cupric chloride in acetic acid analogous to the teachings of Yaleand Sowinski, J. Org. Chem., 25, 1824 (1960).

Alternatively, sulfonyl chlorides of Formula IX can be prepared by amodification of the above procedure whereby the diazotization reactionis carried out in dilute sulfuric acid and the resulting diazonium saltis reacted with sulfur dioxide, HCl and cupric chloride in a cosolventmixture consisting of acetic acid-water (1:1) and an immiscible, inertsolvent such as 1-chlorobutane or methylene chloride at 0°-40° C. for 1to 24 hours.

Many of the sulfonyl chlorides of Formula IX can also be prepared byoxidative chlorination of the corresponding thio compounds of FormulaXII as shown in Equation 15. R' is H, alkyl, benzyl or carbamoyl, R₁ isnot SCH₃ and J does not contain non-aromatic unsaturation. ##STR34##

The reaction is carried out by addition of molecular chlorine or achlorine equivalent to the thio compound in the presence of water at 0°to 80° C. in an aliphatic carboxylic acid solvent such as acetic acid oran inert organic solvent such as dichloroethane for 1 to 24 hours.

Alternatively, many of the sulfonyl chlorides of Formula IX can beprepared by the two-step sequence shown in Equation 16 starting from thethio compounds XII where R' is H (XIIa) and R₁ is not SCH₃. ##STR35##

The thiol XII (R'=H) is contacted with excess hydrogen peroxide in thepresence of base to give a sulfonic acid salt which in turn is convertedto the desired sulfonyl chloride by contacting with a suitable reagentsuch as thionyl chloride or phosphorous pentachloride as known to oneskilled in the art.

Some of the sulfonyl chlorides of Formula IX may best be prepared bydirect chlorosulfonation depending on the substitution pattern on thering and the nature of the substituent as will be known to one skilledin the art.

Many of the S-arylthiocarbamates of Formula XIIb (XII, R'=CON(CH₃)₂) canbe prepared by the Newman-Kwart rearrangement starting with thecorresponding phenols XIII as shown in Equation 17. ##STR36##

The phenol XIII is first reacted with N,N-dimethylthiocarbamoyl chloridein the presence of a base. The resultingO-aryl-N,N-dimethylthiocarbamate XIV is then heated at 150° C. to 300°C. for 2 to 24 hours as taught by Newman and Karnes J. Org. Chem., 31,3980 (1966) to give the desired S-aryl-N,N-dimethylthiocarbamate XIIb.The related thiols XIIa can be obtained by hydrolysis of thethiocarbamates XIIb.

Many of the sulfides of Formula XII where R' is alkyl or benzyl can beprepared by reacting a halocompound of Formula XV with an appropriatemercaptan in the presence of a base as shown in Equation 18. R' is alkylor benzyl and X is F, Cl or Br. ##STR37##

The reaction is carried out in a solvent such as DMF at 25° to 150° C.for 0.5 to 24 hours. The halocompounds XV must not contain functionalitywhich can be attacked by a mercaptide anion as will be known to oneskilled in the art. An example of this would be where J is J₁ and R₂ wasa haloalkyl group. These compounds can be prepared from thecorresponding sulfides XII where J is J₁, R' is alkyl or benzyl and R₂is H by standard alkylation methods.

Many of the thiocompounds XII of Equation 15 and the chlorocompounds XV(X=Cl) of Equation 18, where J is J₁ and n is O, can be prepared by thereaction sequence shown in Equation 19. G is Cl or S-alkyl, R₁ does notcontain functionality incompatible with BuLi or BH₃ and R₃ is aspreviously defined. ##STR38##

The sequence begins by contacting an appropriately substitutedN-t-butylbenzenesulfonamide XVI with two equivalents of butyl lithium at0° to 25° C. in an inert solvent such as THF for 2 to 10 hours to give adianion according to the teachings of J. Lombardino, J. Org. Chem., 36,1843 (1971). The dianion can then be trapped with an ester or, when R₃is H, with dimethylformamide at -78° to 25° C. to produce, upon aqueousacid workup, the hemiaminal XVII. The hemiaminal XVII can bede-t-butylated and dehydrated by a catalytic amount of acid such asp-toluene-sulfonic acid in a solvent such as benzene or toluene atreflux. The resulting benzisothiazole XVIII can be reduced with areagent such as sodium borohydride in a suitable solvent such as ethanolto produce a 2,3-dihydrobenzisothiazole which is N-alkylated asdescribed in equation II to give either XII (J=J₁, R'=alkyl) or XV(J=J₁, X=Cl) by standard methods known to one skilled in the art.Alternatively, hemiaminal XVII may be treated with diborane to produce at-butyl-2,3-dihydrobenzisothiazole XVIIIa. Compounds XII (J=J₁,R'=alkyl) or XV (J=J₁, X=Cl) are then readily prepared as describedpreviously by treatment of XVIIIa with trifluoroacetic acid followed byN-alkylation. If the t-butyl group in structures XVI and XVII isreplaced by the appropriate R₂ group, the diborane reduction of thehemiaminal gives XII and XV directly.

Many of the thio compounds XII of Equation 15 and the chloro compoundsXV of Equation 18, where J is J₁ and J₄ and n=1, can be prepared by thereaction sequence shown in Equation 20. G is Cl or S-alkyl, Y is H orCH₃, R₁ does not contain functionality incompatible with BuLi. R" isC(CH₃)₃ or functionality selected from R₂ which is compatible with thelithiation conditions shown as will be known to one skilled in the artand R₄ is H or C₁ -C₄ alkyl. ##STR39##

The reaction is carried out by reacting the N-substitutedbenzenesulfonamides XIX with two equivalents of n-BuLi at -78° to 25° C.in a solvent such as THF for 0.5 to 5 hours. When Y is H, an ortho-anionis formed which is trapped with an appropriate epoxide to give thehydroxy sulfonamides XX. When Y is CH₃, an ortho-methyl anion isproduced which is reacted with an aldehyde or DMF to give alcohol XX.The alcohol can be mesylated by reaction of XX with mesyl chloride inthe presence of an equivalent of a tertiary amine at 0° to 25° C. for 1to 24 hours in a solvent such as methylene chloride. The resultingmesylate is cyclized by heating with a base such as potassium carbonatein a solvent such as DMF to produce the desired compounds XII (J=J₁, J₄,R'=alkyl) or XV (J=J₁, J₄, X=Cl). When R" is C(CH₃)₃, contacting withacid as described in Equation 10 will give the correspondingbenzisothiazine where R" is H. This can be alkylated as describedpreviously for the benzisothiazoles of Equation 19.

Many of the thio compounds of Formula XII, where J is J₆ or J₁₀ (W₁ =O),can be prepared from the thioether compounds XXI shown in Equation 21. Yis H or CH₃, R₁ ' does not contain Br, R' is C₂ -C₄ alkyl, R₆ is H orCH₃ and R₇ is H or C₁ -C₄ alkyl. ##STR40##

The reaction is carried out by reacting the N-methylcarboxamide XXI withtwo equivalents of n-BuLi at -78° to 25° C. in a solvent such as THF for0.5 to 5 hours to give, when Y is H, an orthoanion which is trapped withan appropriate epoxide to give the hydroxy sulfonamides XXII as taughtby Narasimkan and Bhide, Chem. Comm., 1552 (1970). When Y is CH₃, anortho methyl anion is produced which is reacted with an aldehyde orslowly enolizable ketones to give the amides XXII as taught by Watanabeet al. Tetrahedron Lett. 1647 (1982). The amides XXII are saponified bystandard methods to the corresponding benzoic acids which readilycyclize upon heating in the presence of acid such as p-toluenesulfonicacid to give the desired lactones XII (J=J₆, J₁₀, R'=alkyl).

The amines of Formula XI in Equation 14, can be prepared by reduction ofthe corresponding nitro compounds of Formula XXI, as shown in Equation22. ##STR41##

The reduction of nitro compounds to amines can be carried out by any ofseveral known methods as described in Preparative Organic Chemistry, 4Ed., p. 557-563, John Wiley and Sons, New York and London, G. Hilgetagand A. Martini Ed.

Many of the nitro compounds of Formula XXIII in Equation 22 can beprepared by the procedures outlined in Equations 23 through 30. Withsuitable modifications known to one skilled in the art, the general ringforming reactions outlined below for these nitro compounds XXIII can beadapted to prepare many of the phenols of Formula XIII and halocompoundsof Formula XV.

As shown in Equation 23, many of the nitro compounds of Formula XXI,where J is J₁ (XXIIIa) can be prepared starting from the appropriatelysubstituted nitrobenzenes of Formula XXII. R' is H or CH₂ Cl. ##STR42##

The nitrobenzenes XXIV are first reduced to their corresponding aminesand nitrated by standard methods to produce, in part, compounds ofFormula XXV. In some instances, it may be desirable to first protect theamino group as its acetate prior to nitration as is known to one skilledin the art. The desired nitro compound XXV can be isolated by eitherfractional crystallization or chromatographic procedures and convertedto sulfonyl chlorides XXVI by the method previously discussed inEquation 14. The intermediate sulfonyl chlorides XXVI can be convertedinto their corresponding sulfonamides by reaction with an appropriateamine (see Equation 9) and subsequently cyclized: (a) when R' is CH₂ Cl,to the nitro-1,2-benzothiazines XXIIIa, where n is 1, by heating in thepresence of a base such as potassium carbonate; or (b) when R' is H, bycontacting the sulfonamide with NBS in a solvent such as carbontetrachloride to give sulfonamides where R' is Br, followed bycontacting this product with a base to give the nitro benzisothiazolesXXIa where n is 0. Note the discussion of Equation 12 for NBSbrominations when R₁ is alkyl.

The procedure of Equation 23 is similar to the method taught by E.Sianesi et al., Chem. Ber., 104, 1880 (1971) for the preparation ofsubstituted 1,2-benzothiazine-1,1-dioxides. The starting nitrobenzenesXXII can be prepared by standard methods known to one skilled in theart.

Alternatively, as shown in Equation 24, many of the nitro compounds ofFormula XXIIIa where n is 1 can be prepared, in part, by contacting thenitro acetamides XXVII with fuming sulfuric acid according to the methodtaught by H. Zenno and T. Mizutani, (Chem. Abst.: 72:79122 (1970)) forthe preparation of 7-nitro-1,2-benzothiazine-1,1-dioxide. The resultingbenzothiazines can be isolated and subsequently alkylated by standardmethods known to one skilled in the art. ##STR43##

Many of the nitro compounds of Formula XXIIIa where n is 0 can also beprepared from the corresponding 1,2-benzisothiazoles XXVI as shown inEquation 25. ##STR44##

Nitration of XXVIII gives, in part, the 7-nitro derivative which isisolated by standard methods. The derivative is converted to its1,1-dioxide by treatment with hydrogen peroxide. Reduction of thecarbon-nitrogen double bond with NaBH₄ followed by alkylation of theresulting sulfonamide gives compounds XXIIIa where n is 0. The abovereactions are characteristic of 1,2-benzisothiazoles XXVIII. For reviewsof their synthesis and reactions, see L. L. Bambas, "The Chemistry ofheterocyclic Compounds," Vol. 4, part III, 1952, p. 223-378, and M.Davis, Adv. Heterocyclic Chem., Vol. 14 (1972) p. 43-98.1,2-Benzothiazines are also well known in the literature, for a reviewof their chemistry and alternate methods of their preparation see J. G.Lombardino, D. E. Kuhla, Adv. Heterocyclic Chem., Vol. 28 (1981) p.73-126.

As shown in Equation 26, many of the nitro compounds of Formula XXIIIwhere J=J₆ (W₁ =O) (XXIIId) can be prepared from the appropriatelysubstituted amines XXV. R' is H or CH₂ Cl. ##STR45##

The nitro amines XXV, previously described in Equation 23, can beconverted into the corresponding cyano compounds XXIX by the "SandmeyerReaction" (T. Sandmeyer, Chem. Ber., 17, 1633, 2650 (1884)). The cyanofunction is hydrolyzed to a carboxylic acid by methods known to oneskilled in the art, and the carboxylic acids or their correspondingesters can be (a) cyclized to the nitro isocoumarins XXIIId (n=1) byheating in the presence of base when R' is CH₂ Cl, or (b) cyclized tothe nitro phthalides XXIIId (n=0) when R' is H by first brominating withNBS or bromine (note discussion of Equation 12 for brominations when R₁' is alkyl) followed by heating in a solvent such as aqueous dioxane.The latter method is that taught by J. A. Houbion et al., Org. Prep. andProcedures Int., 11, 27 (1979) for the preparation of 7-nitrophthalide(XXIIId, n=0, R₁ '=R₃ =H).

The procedure of Equation 26 is similar to the method of P. Banejce andD. Chaudhury, J. Org. Chem., 26, 4344 (1961) for the preparation ofsubstituted isocoumarins; similar methods can be utilized for thepreparation of isocoumarins of the J₁₀ (W₁ =O) type. Isocoumarins arewell known in the literature, for a review of their synthesis andreactions see R. Barry, Chem. Rev., 64, 229-260 (1964).

Many of the nitro compounds of Formula XXIII, where n=0 can also beprepared by reduction of the corresponding 3-nitrophthalic anhydrideswith either sodium borohydride or lithium aluminum hydride intetrahydrofuran as taught by M. kayser and P. Morand, Can. J. Chem., 58,2848 (1980) for the preparation of 7-nitrophthalide (XXIIId; n=0, R₁'=H). Phthalides and phthalic anhydrides are well known in the art, fora review of their synthesis and reactions see, S. Wawzonek, HeterocyclicCompounds, Vol. 2, John Wiley and Sons. Inc., New York, 1951.

As shown in Equation 27, many of the nitro compounds of Formula XXIIIwhere J is J₅ (W₁ =O) (XXIIIe) can be prepared from the appropriatelysubstituted benzonitriles XXIX. R' is H or CH₂ Cl. ##STR46##

The benzonitriles XXIX, previously described in Equation 26, arehydrolyzed to carboxylic acids, converted to their corresponding acidchlorides by contacting with a reagent such as thionyl chloride andsubsequently reacted with the appropriate amine, by standard methods, togive the amides XXX. The intermediate amides XXX can be cyclized to thenitro compounds XXIIIe by the procedures previously described inEquation 23 for converting sulfonamides of XXVI into nitro compoundsXXIIIa.

Alternatively, many of the nitro compounds of Formula XXIIIe can beprepared from the nitro compounds of Formula XXIIId as shown in Equation28. ##STR47##

The reactions of phthalides with amines to produce phthalimidines iswell known, see C. Hollins, The Synthesis of Nitrogen Ring Compounds,Ernest Benn Limited, London, 1924. In these reactions, heating thephthalides (XXIIId, n=0) with an amine produces the phthalimidines(XXIIIe, n=0) directly, the intermediate alcohols XXXI (n=0) are notisolated. With the 3,4-dihydrocoumarins (XXIIId, n=1) the intermediateamide alcohols XXXI (n=1) are formed (see P. Maitte, Colloq. Intern.Centre Natl. Rech. Sci. (Paris), 64, 197 (1955), Chem. Abst., 55:10426(1961)) and can be converted to the dihydroisoquinolines XXIIIe (n=1) byfirst conversion to the corresponding mesylate followed by heating witha base as described above in Equation 20 for the preparation ofcompounds XII (J=J₁, R'=alkyl) and XV (J=J₁, X=Cl) from the sulfonamidealcohols XX. For a comprehensive review of the synthesis and reactionsof dihydroisoquinolones see N. J. McCorkindale, The Chemistry ofHeterocyclic Compounds, Vol. 38, part III, John Wiley and Sons, NewYork, in press.

As shown in Equation 29, many of the nitro compounds of Formula XXIIIwhere J is J₇ (W₁ =O) (XXIIIf) can be prepared from the appropriatelysubstituted nitrobenzenes XXIV. R' is Br or CH₂ Br. ##STR48##

The nitrobenzenes XXIV, previously discussed in Equation 23, are reactedwith potassium cyanide in a solvent such as acetone to give nitrileintermediates which are hydrolized to the corresponding carboxylic acidsXXXII by standard methods known to one skilled in the art. The nitrocarboxylic acids XXXII, when reduced by standard methods (see discussionof Equation 22), spontaneously cyclize to give the lactams XXXIII. For adiscussion of this reaction when n is 0, see W. Sumpter and F. Miller,The Chemistry of Heterocyclic Compounds, Vol. 32, John Wiley and Sons,New York, 1977, p. 216-217, and references cited therein. The nitrolactams XXIIIf are prepared in part from lactams XXXIII by standardnitration and alkylation procedures known to one skilled in the art.

Alternatively, many lactams XXXIII of Equation can be prepared from thesubstituted anilines XXXIV as shown in Equation 30. ##STR49##

The substituted anilines XXXIV are reacted with either a chloroacetylchloride (n=0) or β-chloropropionyl chloride (n=1, R₃ =H) in thepresence of an acid scavenger to give the chloro amides XXXV. The amidesXXXV are cyclized by heating in the presence of a suitableFriedel-Crafts reagent such as AlCl₃ to give the lactams XXXIII. Themethod of Equation 30 has been widely used for the preparation ofoxindoles (XXXIII, n=0; see W. Sumpter and F. Miller, loc. cit., p.135-136 for discussion and references) and for the preparation of3,4-dihydro-2-quinolones (XXXIII, n=1; see G. Jones, loc. cit., p.164-168 for discussion and references). For a general review of oxindolechemistry see W. Sumpter and F. Miller, loc. cit., p. 134-153.

Many of the nitro compounds of Formula XXIII in Equation 22 where J isJ₂, J₃, J₈ (W₁ =O) and J₉ (W₁ =O) can be prepared from the correspondingnitro compounds of Formula XXIII where J is J₁ (n=1), J₄, J₅ (W₁ =O) andJ₇ (W₁ =O), respectively, by the bromination-dehydrobromination sequencedescribed above for sulfonamides IV in Equation 12.

The amines of Formula III in Equations 1 and 3 are also importantintermediates for the preparation of the compounds of this invention andare described below.

The pyrimidines and triazines of Formula (IIIa) to (IIId) below areeither known or can be prepared by methods obvious to one skilled in theart. ##STR50##

For a review of the synthesis and reactions of 2-aminopyrimidines (IIIa,Z=CR') see The Chemistry of Heterocyclic Compounds, Vol. 16, John Wileyand Sons, New York (1962). For a review of the synthesis and reactionsof 2-amino-s-triazines (IIIa, Z=N) see The Chemistry of HeterocyclicCompounds, Vol. 13, John Wiley, New York (1959), F. C. Schaefer, U.S.Pat. No. 3,154,547 and F. C. Schaefer and K. R. Huffman, J. Org. Chem.,28, 1812 (1963). The synthesis of the bicyclic amines IIIb and IIIc istaught in European Patent Application No. 15,683. The synthesis ofbicyclic amines IIId is taught in European Patent Application No.46,677. The synthesis of amines IIIa where X is cyclopropyl is taught inSouth African Patent Application No. 83/7434.

The amines of Formula III where X is OCF₂ H, OCH₂ F, OCF₃ or CF₃ ; or X₁is OCF₂ H and/or Y is OCH₂ F, OCF₃, SCH₂ F, SCF₃ or GCF₂ T wherein G isO or S and T is H, CHClF, CHBrF or CHFCF₃ can be prepared by methodsthat would be obvious to one skilled in the art.

The pyrimidines of Formula IIIa (Z=CH) where Y is ##STR51## can beprepared according to the methods known to one skilled in the art.

The triazine amines of Formula IIIe where X₃ is CH₃ or OCH₃ and R is Hor CH₃ can be prepared according to the teachings of European PatentApplication No. 94,260. ##STR52##

Preparation of 3-amino-1,2,4-triazoles of Formula IIIf are known in theart and 1,2,4-triazoles are reviewed in The Chemistry of HeterocyclicCompounds "Triazoles 1,2,4" (John Wiley and Sons, New York, 1981).Commonly used starting materials containing nitrogen areN-aminoguanidine, hydrazine, alkylhydrazines, cyanamide, ethylcyanoacetimidate, dimethyl cyanodithioimidocarbonate, dimethylcyanoimidocarbonate, ethoxymethylenecyanamide, and acylhydrazines. Someliterature syntheses are illustrated below. Using these techniques orsuitable modifications that would be apparent to one skilled in the art,the 3-amino-1,2,4-triazole intermediates can be readily prepared.

Heating equimolar amounts of ethyl propionimidate hydrochloride andN-aminoguanidine nitrate in pyridine gives 3-amino-5-ethyltriazole;German Patent No. 1,073,499 (1960); Berichte, 96, 1064 (1963). ##STR53##Condensation of hydrazine with ethyl N-cyanoacetimidate yields3-amino-5-methyltriazole; Journal of Organic Chemistry, 28, 1816 (1963).##STR54## U.S. Pat. No. 2,835,581 (1958) teaches the preparation of3-amino-5-(hydroxymethyl)triazole from N-amino-guanidine and glycolicacid. ##STR55## Condensing hydrazine with dimethylcyanodithioimidocarbonate in acetonitrile gives3-amino-5-methylthio-1,2,4-triazole while reaction of hydrazine withdimethyl N-cyanoimidocarbonate produces3-amino-5-methoxy-1,2,4-triazole; Journal of Organic Chemistry, 39, 1522(1974). ##STR56##

Reaction of substituted hydrazines with N-cyanothioimidocarbonates(prepared according to the procedure given in D. M. Wieland, Ph.D.Thesis, 1971, pp. 123-124) yields disubstituted aminotriazoles as shownbelow. ##STR57##

Many of the aminoheterocyclic intermediates of Formula III where R ismethyl may be prepared by a two-step procedure as described for IIIg inEquation 31, wherein X, Y and Z are as previously defined. ##STR58##

A solution of the amine XXXVI in concentrated hydrochloric acid istreated with sodium nitrate solution and the chloro compound XXXVII isisolated in the usual manner by filtration of the acidic solution. Arepresentative procedure is described by Bee and Rose in J. Chem. Soc.C, 2031 (1966), for the case in which Z=CH, and X=Y=OCH₃. Displacementof the chlorine of XXXVII may be accomplished by heating with an excessof methylamine in water to obtain the methylamino heterocycle (IIIg).

Quaternization of amino functionality present in the R₂ group ofcompounds of formula I are also useful as herbicides and can be preparedby standard methods known to one skilled in the art.

Agriculturally suitable salts of compounds of Formula I are also usefulherbicides and can be prepared in a number of ways known to the art. Forexample, metal salts can be made by contacting compounds of Formula Iwith a solution of an alkali or alkaline earth metal salt having asufficiently basic anion (e.g., hydroxide, alkoxide, carbonate orhydride). Quaternary amine salts can be made by similar techniques.

Salts of compounds of Formula I can also be prepared by exchange of onecation for another. Cationic exchange can be effected by directcontacting of an aqueous solution of a salt of a compound of Formula I(e.g., alkali metal or quaternary amine salt) with a solution containingthe cation to be exchanged. This method is most effective when thedesired salt containing the exchanged cation is insoluble in water,e.g., a copper salt, and can be separated by filtration.

Exchange may also be effected by passing an aqueous solution of a saltof a compound of Formula I (e.g., an alkali metal or quaternary aminesalt) through a column packed with a cation exchange resin containingthe cation to be exchanged. In this method, the cation of the resin isexchanged for that of the original salt and the desired product iseluted from the column. This method is particularly useful when thedesired salt is water-soluble, e.g., a potassium, sodium or calciumsalt.

Acid addition salts, useful in this invention, can be obtained byreacting a compound of Formula I with a suitable acid, e.g.,p-toluenesulfonic acid, trichloroacetic acid or the like.

EXAMPLE 12-t-Butyl-3-hydroxy-7-chloro-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide

To a solution of 49.5 g of N-t-butyl-2-chlorobenzenesulfonamide in 875mls of dry THF was added 262 ml of a 1.6M hexane solution of n-butyllithium at -20° to -5° C. under an inert atmosphere. The mixture wasstirred at 0° C. for 1 hour, room temperature for 2 hours, recooled to-78° C. and contacted with 38 mls of dry dimethylformamide. The mixturewas allowed to warm to room temperature overight, poured into water,acidified to a ph of ˜3 and ether extracted. The extract was washed withwater and brine, dried over MgSO₄ and concentrated to give a yellow oil.The oil was dissolved in 50% ether in hexane solution and allowed tostand, giving, after filtration, 38 g of the title compound as colorlesscrystals, m.p. 139°-141° C.

90 MHz NMR (CDCl₃) δ: 7.7-7.2 (m, 3H, arom); 5.9 (br. d, J=11 Hz, 1H,CH; 4.2 (br. d, J=11 Hz, 1H, OH; and 1.5 (s, 9H, CH₃ 's).

IR (nujol) 3440 cm⁻¹.

EXAMPLE 2 7-Chloro-1,2-benzisothiazole-1,1-dioxide

A solution of 37 g of2-t-butyl-3-hydroxy-7-chloro-2,3-dihydro-1,2-benzoisothiazole-1,1-dioxideand 0.2 g of tosic acid in 370 mls of benzene was refluxed through aDean-Stark water separator for 16 hours, cooled in ice and filtered togive 18.9 g of the title compound as colorless crystals, m.p. 162°-164°C.

90 MHz NMR (CDCl₃) δ: 9.15 (s, 1H, CH); and 8.0-7.7 (m, 3H, arom).

IR (nujol) 1445, 132, 1170 cm⁻¹.

EXAMPLE 3 7-Chloro-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide

A suspension of 17.9 g of 7-chloro-1,2-benzisothiazole-1,1-dioxide in180 ml of absolute ethanol was cooled to 0° C. and treated with 3.33 gof sodium borohydride at such a rate that the temperature remained below5° C. The mixture was warmed to room temperature for 30 minutes,recooled to 0° C. and contacted with glacial acetic acid to destroyexcess hydride. The mixture was concentrated to dryness, the resultingsolid suspended in water, filtered, washed with water and dried in vacuoat 50° C. for 16 hours to give 17.6 g of the title compound as a whitepowder, m.p. 159°-161° C.

90 MHz NMR (CDCl₃ /DMSO-d₆) δ: 7.9-7.2 (m, 3H, arom); 6.9 (br, 1H, NH);and 4.4 (s, 2H, CH₂).

IR (nujol) 3220 cm⁻¹.

EXAMPLE 4 2-Pentyl-7-chloro-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide

A suspension of 10.2 g of7-chloro-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide, 8.3 g of potassiumcarbonate and 7.7 ml of 1-iodopentane was refluxed in 50 ml of ethanolfor 28 hours, cooled, concentrated and added to 200 ml of water. Themixture was extracted with n-BuCl, the extract washed with water andbrine, dried over MgSO₄ and concentrated to give 13.3 g of an amber oilwhich was triturated with hexane to give 11.4 g of the title compound asa tan powder, m.p. 46°-48° C.

90 MHz NMR (CDCl₃) δ: 7.7-7.2 (m, 3H, arom); 4.3 (s, 2H, CH₂); 3.3 (t,2H, CH₃); and 2.0-0.7 (m, 9H, alkyl).

IR (nujol) 1573, 1300, 1170, 1158 cm⁻¹.

EXAMPLE 52-Pentyl-7-(propylthio)-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide

To a solution of 5.0 g of potassium-t-butoxide in 40 ml of drydimethylformamide was added 4.0 ml of propyl mercaptan at -5° C. to 0°C. under an inert atmosphere followed by 11.0 g of2-pentyl-7-chloro-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide. Themixture was stirred at room temperature for 16 hours, poured into waterand extracted with n-butyl chloride. The extract was washed with waterand brine, dried over MgSO₄ and concentrated to give 10.3 g of the titlecompound as a yellow oil.

60 MHz NMR (CDCl₃) δ: 7.7-7.0 (m, 3H, arom); 4.3 (s, 2H, CH₂); 3.4-2.9(m, 4H, CH₂); and 2.0-0.8 (m, 14H, alkyl).

IR (neat) 1582, 1455, 1300, 1170, 1155 cm⁻¹.

EXAMPLE 62-Pentyl-2,3-dihydro-1,2-benzisothiazole-7-sulfonamide-1,1-dioxide

A solution of 9.5 g of2-pentyl-7-(propylthio-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide in 40ml of acetic acid containing 1.3 ml of water was contacted with 7.0 mlof liquified chlorine at 10° to 15° C. and allowed to warm to 25° C. Theexcess chlorine was removed via a stream of nitrogen gas and thesolution was poured onto ice. The resulting solid was filtered, washedwith water and hexane, dried, dissolved in CH₂ Cl₂ and contacted with2.0 ml of liquified ammonia at -78° to 25° C. The mixture was added to100 ml of 1N HCl and extracted with CH₂ Cl₂. The extract was washed withwater and brine, dried over MgSO₄, concentrated and slurried in ether togive 6.35 g of the title compound as a white powder, m.p. 156°-160° C.

60 MHz NMR (CDCl₃ /DMSO-d₆) δ: 8.2-7.6 (m, 3H, arom); 6.7 (b, 2H, NH₂);4.4 (s, 2H, CH₂); 3.3 (t, 2H, CH₂); and 2.0-0.8 (m, 9H, alkyl).

IR (nujol) 3370, 3270, 1540, 1285 cm⁻¹.

EXAMPLE 7N-[(4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-2-pentyl-2,3-dihydro-1,2-benzisothiazole-7-sulfonamide-1,1-dioxide

A solution of 0.32 g of2-pentyl-2,3-dihydro-1,2-benzisothiazole-7-sulfonamide-1,1-dioxide and0.28 g of O-phenyl-N-(4,6-dimethoxypyrimidin-2-yl)carbamate in 5 ml ofdry acetonitrile was treated with 0.15 ml of1,8-diazobicyclo[5.4.0]undec-7-ene. The solution was stirred at 25° C.for 10 minutes, diluted with 10 ml of water, cooled to 0° C. andacidified with 1N HCl. The resulting precipitate was filtered, washedwith water and ether and air dried to give 0.43 g of the title compoundas a white powder, m.p. 197°-203° C.

200 MHz NMR (CDCl₃) δ: 13.0 (b, 1H, NH); 8.34 (d, 1H, arom); 7.77 (t,1H, arom); 7.64 (d, 1H, arom); 7.12 (b, 1H, NH); 5.77 (s, 1H, CH); 4.34(s, 2H, CH₂); 4.00 (s, 6H, OCH₃ 's); 3.24 (m, 2H, CH₂); 1.75 (m, 2H,CH₂); 1.36 (m, 4H, CH₂ 's); and 0.88 (t, 3H, CH₃).

IR (nujol) 1730, 1710, 1610 cm⁻¹.

EXAMPLE 8 N-Methylisoindolin-1-thione-7-sulfonamide

A mixture of 0.68 g of N-methylisoindolin-1-one-7-sulfonamide, 0.61 g ofLawesson's reagent(2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulfide)and 15 ml of xylene was heated to reflux under nitrogen for 24 hours.The mixture was allowed to cool, the solid products collected, andrecrystallized from isopropanol (carbon) to give 0.31 g of the titlecompound as a yellow solid, m.p. 231°-232° C.

90 MHz NMR (CDCl₃ /DMSO-d₆) δ: 3.60 (s, 3H, NCH₃); 5.08 (s, 2H, CH₂);7.28 (s, 2H, NH₂); and 7.5-8.3 (m, 3H, arom).

EXAMPLE 9N-[(4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-2-methylisoindolin-1-thione-7-sulfonamide

To a mixture of 0.14 g of N-methylisoindolin-1-thione-7-sulfonamide and0.16 g of N-(4,6-dimethoxypyrimidin-2-yl)-O-phenylcarbamate in 5 ml ofacetonitrile was added dropwise 0.085 ml of DBU. The deep red solutionwas stirred for 30 minutes, diluted with 5 ml of water, acidified to pH6 with 5% HCl, the solid collected, washed with water, washed withether, and dried in vacuo to give 0.06 g of the title compound as a paleyellow solid, m.p. 202°-203.5° C. (d).

200 MHz NMR (CDCl₃): δ 3.61 (s, 3H, NCH₃); 3.96 (s, 6H, OCH₃ 's); 5.28(s, 2H, CH₂); 5.80 (s, 1H, pyrimidine C₅ -H); 7.15 (broad s, 1H, NH);7.6 (t, 1H); 8.1 (d, 1H); 8.3 (d, 1H); and 12.9 (broad s, 1H, NH).

IR (nujol) 1720 cm⁻¹.

Using the procedures of Examples 1 to 9 and the methods describedherein, the following compounds of Tables I-V can be prepared.

    TABLE Ia      ##STR59##      W n R R.sub.1 R.sub.2 R.sub.3 X Y Z m.p. (°C.)      O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3     CH.sub.3 CH 189-193 O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3     H CH.sub.3 OCH.sub.3 CH 190-197 O 0 H H CH.sub.2 CH.sub.2 CH.sub.2     CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH 197-203 O 0 H H CH.sub.2     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 N 172-175 O 0 H     H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N     154-158 O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H Cl     OCH.sub.3 CH 204-206 O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2     CH.sub.3 H Br OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2     H CH.sub.3 CH.sub.3 CH 204-206 O 0 H H CH.sub.2 CH.sub.2      CH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH 202-205 O 0 H H CH.sub.2     CH.sub.2 CH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH 227-229 O 0 H H     CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 N 176-177 O 0     H H CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 N 175-178     O 0 H H CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 H Cl OCH.sub.3 CH 215-218 O     0 H H CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 H Br OCH.sub.3 CH O 0 H H     CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H     CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3 H Cl OCH.sub.3 CH O 0 H H     CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3 H Br OCH.sub.3 CH O 0 H H     CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H     CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H     CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H     CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H     CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 H Cl OCH.sub.3 CH O 0 H H     CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 H Br OCH.sub.3 CH O 0 H H     CH.sub.2 C(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     C(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 Ph H     CH.sub.3 CH.sub.3 CH 194-195 O 0 H H CH.sub.2 Ph H CH.sub.3 OCH.sub.3 CH     183-186 O 0 H H CH.sub.2 Ph H OCH.sub.3 OCH.sub.3 CH 216-218 O 0 H H     CH.sub.2 Ph H CH.sub.3 OCH.sub.3 N 180-184 O 0 H H CH.sub.2 Ph H     OCH.sub.3 OCH.sub.3 N 179-183 O 0 H H CH.sub.2 Ph H Cl OCH.sub.3 CH     205-210 O 0 H H CH.sub.2 Ph H Br OCH.sub.3 CH O 0 H H OCH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H H OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     OCH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H OCH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H H OCH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H H OCH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3     CH O 0 H H OCH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H OCH(CH.sub     .3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CHCH.sub.2 H     CH.sub.3 CH.sub.3 CH 220-221 O 0 H H CH.sub.2 CHCH.sub.2 H CH.sub.3     OCH.sub.3 CH 223-224 O 0 H H CH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.3     CH 210-214 O 0 H H CH.sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.3 N 175-177 O     0 H H CH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.3 N 193-195 O 0 H H     CH.sub.2 CHCH.sub.2 H Cl OCH.sub.3 CH 213-215 O 0 H H CH.sub.2      CHCH.sub.2 H Br OCH.sub.3 CH O 0 H H CH.sub.2 CHCHCH.sub.3 H CH.sub.3     CH.sub.3 CH O 0 H H CH.sub.2 CHCHCH.sub.3 H CH.sub.3 OCH.sub.3 CH     215-217 O 0 H H CH.sub.2 CHCHCH.sub.3 H OCH.sub.3 OCH.sub.3 CH 219-222 O     0 H H CH.sub.2 CHCHCH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     CHCHCH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CHCHCH.sub.3 H Cl     OCH.sub.3 CH 216-218 O 0 H H CH.sub.2 CHCHCH.sub.3 H Br OCH.sub.3 CH O 0     H H CH.sub.2 C(CH.sub.3)CH.sub.2 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2     C(CH.sub.3)CH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2      C(CH.sub.3)CH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2      C(CH.sub.3)CH.sub.2 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2      C(CH.sub.3)CH.sub.2 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2            C      C(CH.sub.3)H.sub.2 H Cl OCH.sub.3 CH O 0 H H CH.sub.2      C(CH.sub.3)CH.sub.2 H Br OCH.sub.3 CH O 0 H H CH(CH.sub.3)CHCH.sub.2 H     CH.sub.3 OCH.sub.3 CH O 0 H H CH(CH.sub.3)CHCH.sub.2 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CHCH.sub.2 H CH.sub.3 CH.sub.3 CH     202-204(d) O 0 H H CH.sub.2 CH.sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.3 CH     198-200(d) O 0 H H CH.sub.2 CH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.3 CH     201.5-204(d) O 0 H H CH.sub.2 CH.sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.3 N     O 0 H H CH.sub.2 CH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 CH.sub.2 CHCH.sub.2 H Cl OCH.sub.3 CH 208-210(d) O 0 H H     CH.sub.2 CH.sub.2 CHCH.sub.2 H Br OCH.sub.3 CH O 0 H H CH.sub.2      C(Cl)CH.sub.2 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 C(Cl)CH.sub.2 H     CH.sub.3 OCH.sub.3 CH 216-217 O 0 H H CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3     OCH.sub.3 CH 215-216 O 0 H H CH.sub.2 C(Cl)CH.sub.2 H Cl OCH.sub.3 CH     217-218 O 0 H H CH.sub.2 C(Cl)CH.sub.2 H CH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 C(Cl)CH.sub.2 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2      CHCHCH.sub.2 Cl H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CHCHCH.sub.2     Cl H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2      C(F)CHF H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 C(F)CHF H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CCH H CH.sub.3 OCH.sub.3 CH 211- 213 O 0 H     H CH.sub.2 CCH H OCH.sub.3 OCH.sub.3 CH 194-196 O 0 H H CH.sub.2     CCCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CCCH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2      CCH H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CCH H OCH.sub.3     OCH.sub.3 CH O 0 H H CH(CH.sub.3)CCH H CH.sub.3 OCH.sub.3 CH O 0 H H     CH(CH.sub.3)CCH H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CCCH.sub.2 Cl     H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CCCH.sub.2 Cl H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CCCH.sub.2 OH H CH.sub.3 OCH.sub.3 CH O 0     H H CH.sub.2 CCCH.sub.2 OH H OCH.sub.3 OCH.sub.3 CH O 0 H H CF.sub.2 H H     CH.sub.3 CH.sub.3 CH O 0 H H CF.sub.2 H H CH.sub.3 OCH.sub.3 CH O 0 H H     CF.sub.2 H H OCH.sub.3 OCH.sub.3 CH O 0 H H CF.sub.2 H H CH.sub.3     OCH.sub.3 N O 0 H H CF.sub.2 H H OCH.sub.3 OCH.sub.3 N O 0 H H CF.sub.2     H H Cl OCH.sub.3 CH O 0 H H CF.sub.2 H H Br OCH.sub.3 CH O 0 H H     CF.sub.2 CF.sub.2 H H CH.sub.3 CH.sub.3 CH O 0 H H CF.sub.2 CF.sub.2 H H     CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CF.sub.3 H CH.sub.3 CH.sub.3 CH     215-216 O 0 H H CH.sub.2 CF.sub.3 H CH.sub.3 OCH.sub.3 CH 218-219 O 0 H     H CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CH 198-199 O 0 H H CH.sub.2     CF.sub.3 H CH.sub.3 OCH.sub.3 N 168-170 O 0 H H CH.sub.2 CF.sub.3 H     OCH.sub.3 OCH.sub.3 N 158-163 O 0 H H CH.sub.2 CF.sub.3 H Cl OCH.sub.3     CH 211-213 O 0 H H CH.sub.2 CF.sub.3 H Br OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 F H CH.sub.3 CH.sub.3 CH 214-215 O 0 H H CH.sub.2 CH.sub.2 F H     CH.sub.3 OCH.sub.3 CH 218-219 O 0 H H CH.sub.2 CH.sub.2 F H OCH.sub.3     OCH.sub.3 CH 212-214 O 0 H H CH.sub.2 CH.sub.2 F H CH.sub.3 OCH.sub.3 N     190-192 O 0 H H CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 N 195-196 O 0     H H CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CH 215-217 O 0 H H CH.sub.2     CH.sub.2 F H Br OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 Cl H CH.sub.3     CH.sub.3 CH 204-205 O 0 H H CH.sub.2 CH.sub.2 Cl H CH.sub.3 OCH.sub.3 CH     216-217 O 0 H H CH.sub.2 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH 206-208 O     0 H H CH.sub.2 CH.sub.2 Cl H CH.sub.3 OCH.sub.3 N 127-128 O 0 H H     CH.sub.2 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 N 132-133 O 0 H H CH.sub.2     CH.sub.2 Cl H Cl OCH.sub.3 CH 219-220 O 0 H H CH.sub.2 CH.sub.2 Cl H Br     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 Br H CH.sub.3 CH.sub.3 CH 215-216     O 0 H H CH.sub.2 CH.sub.2 Br H CH.sub.3 OCH.sub.3 CH 211-212 O 0 H H     CH.sub.2 CH.sub.2 Br H OCH.sub.3 OCH.sub.3 CH 210-212 O 0 H H CH.sub.2     CH.sub.2 Br H CH.sub.3 OCH.sub.3 N 168-171 O 0 H H CH.sub.2 CH.sub.2 Br     H OCH.sub.3 OCH.sub.3 N 121-123 O 0 H H CH.sub.2 CH.sub.2 Br H Cl     OCH.sub.3 CH 222-224 O 0 H H CH.sub.2 CH.sub.2 Br H Br OCH.sub.3 CH O 0     H H CH.sub.2 CH(Cl)CH.sub.2 Cl H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH(Cl)CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2      CH(Br)CH.sub.2 Br H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2      CH(Br)CH.sub.2 Br H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CCl.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CCl.sub.3 H OCH.sub.3 OCH.sub.3     CH O 0 H H CH.sub.2 CH(OH)CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH(OH)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 CH.sub.2 OH H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     CH.sub.2 OH H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CN H CH.sub.3     OCH.sub.3 CH 228-230 O 0 H H CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CH     234-236 O 0 H H CH.sub.2 CH.sub.2 CN H CH.sub.3 CH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 CN H CH.sub.3 OCH.sub.3 CH 228-230 O 0 H H CH.sub.2     CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CH 198-193 O 0 H H CH.sub.2 CH.sub.2     CN H CH.sub.3 OCH.sub.3 N 173-176 O 0 H H CH.sub.2 CH.sub.2 CN H     OCH.sub.3 OCH.sub.3 N 199-203 O 0 H H CH.sub.2 CH.sub.2      CN H Cl OCH.sub.3 CH 231-235 O 0 H H CH.sub.2 CH.sub.2      CN H Br OCH.sub.3 CH O 0 H H CH.sub.2 CH(CH.sub.3)CN H CH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH(CH.sub.3)CN H OCH.sub.3 OCH.sub.3 CH O     0 H H CH.sub.2 CH.sub.2 CH.sub.2 CN H CH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     OCH.sub.3 H CH.sub.3 OCH.sub.3 CH 185-187 O 0 H H CH.sub.2 OCH.sub.3 H     OCH.sub.3 OCH.sub.3 CH 184-186 O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H     CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3     OCH.sub.3 CH 171-175 O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3     OCH.sub.3 CH 194-197 O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3     OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 N     O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 OCH.sub.3 H Br OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2     OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2     OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.2     CH.sub.3 H CH.sub.3 CH.sub.3 CH 195-198 O 0 H H CH.sub.2 CH.sub.2     OCH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH 193-194 O 0 H H CH.sub.2     CH.sub.2 OCH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH 203-204 O 0 H H     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 N 193-195 O 0     H H CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N 187-189     O 0 H H CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 H Cl OCH.sub.3 CH 193-197 O     0 H H CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 H Br OCH.sub.3 CH O 0 H H     CH.sub.2 CH(OCH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2     CH(OCH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2      CH(OCH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2      CH(OCH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2      CH(OCH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2      CH(OCH.sub.3).sub.2 H Cl OCH.sub.3 CH O 0 H H CH.sub.2      CH(OCH.sub.3).sub.2 H Br OCH.sub.3 CH O 0 H H CH.sub.2 CH(OCH.sub.2     CH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CH(OCH.sub.2     CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH(OCH.sub.2     CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH(OCH.sub.2     CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH(OCH.sub.2     CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH(OCH.sub.2     CH.sub.3).sub.2 H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH(OCH.sub.2      CH.sub.3).sub.2 H Br OCH.sub.3 CH O 0 H H CH.sub.2      CH(CH.sub.3)OCH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2      CH(CH.sub.3)OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2      CH(CH.sub.3)OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH(CH.sub.3)OCH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2      CH(CH.sub.3)OCH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2      CH(CH.sub.3)OCH.sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2      CH(CH.sub.3)OCH.sub.3 H Br OCH.sub.3 CH O 0 H H CH.sub.2      CH(CH.sub.3)CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH(CH.sub.3)CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     SCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 SCH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 CH.sub.3 CH     189-190 O 0 H H CH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.3 CH     192-193 O 0 H H CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CH     20-201 O 0 H H CH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.3 N     163-164 O 0 H H CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 N     168-169 O 0 H H CH.sub.2 CH.sub.2 SCH.sub.3 H Cl OCH.sub.3 CH 210-211 O     0 H H CH.sub.2 CH.sub.2 SCH.sub.3 H Br OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 SCH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 SCH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 SO.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O     0 H H CH.sub.2 CO.sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2     CO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH 175-180 O 0 H H CH.sub.2     CO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH 178-184 O 0 H H CH.sub.2     CO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 N 188-192 O 0 H H CH.sub. 2     CO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N 161-164 O 0 H H CH.sub.2     CO.sub.2 CH.sub.3 H Cl OCH.sub.3 CH 128-130 O 0 H H CH.sub.2 CO.sub.2     CH.sub.3 H Br OCH.sub.3 CH O 0 H H CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 CH 179-180 O 0 H H CH.sub.2 CO.sub.2 CH.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH 173-176 O 0 H H CH.sub.2 CH.sub.2     CO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH 214-218 O 0 H H CH.sub.2     CH.sub.2 CO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH 215-217 O 0 H H     CH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 N(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     N(CH.sub.3)CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 N(CH.sub.2 CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 N(CH.sub.2 CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 Si(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3 CH 195-197 O 0 H H     CH.sub.2 Si(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 CH 196-198 O 0 H H     C(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CH 223-224 O 0 H H C(O)CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH 191-193 O 0 H H C(O)CH.sub.2 CH.sub.3 H CH.sub.3     OCH.sub.3 CH 205-206 O 0 H H C(O)CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3     CH 160-161 O 0 H H C(O)CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3     CH 205-206 O 0 H H C(O)CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3     CH 198-199 O 0 H H SO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H     SO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H SO.sub.2 CH.sub.2     CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H SO.sub.2 CH.sub.2     CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H cyclopropyl H     CH.sub.3 OCH.sub.3 CH O 0 H H cyclopropyl H OCH.sub.3 OCH.sub.3 CH O 0 H     H cyclopropyl H CH.sub.3 OCH.sub.3 N O 0 H H cyclopentyl H CH.sub.3     OCH.sub.3 CH 168-170 O 0 H H cyclopentyl H OCH.sub.3 OCH.sub.3 CH     186-189 O 0 H H cyclopentyl H CH.sub.3 OCH.sub.3 N 182-183 O 0 H H     cyclopentyl H Cl OCH.sub.3 CH 233-235 O 0 H H cyclohexyl H CH.sub.3     OCH.sub. 3 CH 222-224 O 0 H H cyclohexyl H OCH.sub.3 OCH.sub.3 CH     224-227 O 0 H H CH.sub.2      -cyclopropyl H CH.sub.3 CH.sub.3 CH 222°d O 0 H H CH.sub.2     -cyclopropyl H CH.sub.3 OCH.sub.3 CH 166-169 O 0 H H CH.sub.2      -cyclopropyl H OCH.sub.3 OCH.sub.3 CH 221-223 O 0 H H CH.sub.2      -cyclopropyl H CH.sub.3 OCH.sub.3 N 193-196 O 0 H H CH.sub.2      -cyclopropyl H OCH.sub.3 OCH.sub.3 N 204-206 O 0 H H CH.sub.2      -cyclopropyl H Cl OCH.sub.3 CH 215-217 O 0 H H CH.sub.2 -cyclopropyl H     Br OCH.sub.3 CH O 0 H H CH.sub.2 -cyclopentyl H CH.sub.3 CH.sub.3 CH O 0     H H CH.sub.2 -cyclopentyl H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     -cyclopentyl H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 -cyclopentyl H     CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 -cyclopentyl H OCH.sub.3 OCH.sub.3     N O 0 H H CH.sub.2 -cyclopentyl H Cl OCH.sub.3 CH O 0 H H CH.sub. 2     -cyclopentyl H Br OCH.sub.3 CH O 0 H H CH.sub.2 -cyclohexyl H CH.sub.3     CH.sub.3 CH 195-198 O 0 H H CH.sub.2 -cyclohexyl H CH.sub.3 OCH.sub.3 CH     148-150 O 0 H H CH.sub.2 -cyclohexyl H CH.sub.3 OCH.sub.3 CH 201-204 O 0     H H CH.sub.2 -cyclohexyl H CH.sub.3 OCH.sub.3 CH 188-191 O 0 H H     CH.sub.2 -cyclohexyl H CH.sub.3 OCH.sub.3 CH 168-170 O 0 H H CH.sub.2     -cyclohexyl H CH.sub.3 OCH.sub.3 CH 175-178 O 0 H H CH.sub.2 -cyclohexyl     H CH.sub.3 OCH.sub.3 CH 161-164 O 0 H H CH.sub.2O H CH.sub.3 OCH.sub.3     CH O 0 H H CH.sub.2O H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2      CHCl.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CHCl.sub.2 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 Cl H CH.sub.3     CH.sub.3 CH 194-197 O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 Cl H CH.sub.3     OCH.sub. 3 CH 176-183 O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 Cl H OCH.sub.3     OCH.sub.3 CH 201-203 O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 Cl H CH.sub.3     OCH.sub.3 N 181-183 O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 Cl H OCH.sub.3     OCH.sub.3 N 176-178 O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 Cl H Cl OCH.sub.3     CH 186-188 O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 Cl H Br OCH.sub.3 CH O 0 H     H CH.sub.2 CH.sub.2 CH.sub.2 Br H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 CH.sub.2 Br H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     CH.sub.2 Br H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2     Br H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 Br H     OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 Br H Cl     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 Br H Br OCH.sub.3 CH O 0     H H CH.sub.2 CH(Cl)CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH(Cl)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 Cl H CH.sub.3     CH.sub.3 CH O 0 H H CH.sub.2 Cl H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     Cl H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 Cl H CH.sub.3 OCH.sub.3 N O     0 H H CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 Cl H Cl     OCH.sub.3 CH O 0 H H CH.sub.2 Cl H Br OCH.sub.3 CH O 0 H .sub.--m-F     CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F     CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F     CH.sub.2 CH.sub.2 CH.sub.2 Cl H CH.sub.3OCH.sub.3 CH O 0 H .sub.-- m-F     CH.sub.2 CH.sub.2 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F     CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-F CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 OCH.sub.3 CH     O 0 H .sub.--m-Cl CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O     0 H .sub.--m-Cl CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0     H .sub.--m-Cl CH.sub.2 CH.sub.2 CH.sub.2 Cl H CH.sub.3 OCH.sub.3 CH O 0     H .sub.--m-Cl CH.sub.2 CH.sub.2 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH O 0     H .sub.--m-Cl CH.sub.2 CH(CH.sub.3)CH.sub.2      CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl CH.sub.2      CH(CH.sub.3)CH.sub.2      CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub. 3 CH.sub.2     CH.sub.2 OCH.sub.3 H CH OCH CH 163-171 O 0 H .sub.--m-CH.sub.3 CH.sub.2     CH.sub.2      OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH 171-176 O 0 H .sub.--m-CH.sub.3     CH.sub.2 CH.sub.2 CH.sub.2      Cl H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2 CH.sub.2     CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2     CH(CH.sub.3)CH.sub.2      CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2     CH(CH.sub.3)CH.sub.2      CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3 CH.sub.2     CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3     CH.sub.2 CH.sub.2      OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3 CH.sub.2     CH.sub.2 CH.sub.2 Cl H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3     CH.sub.2 CH.sub.2 CH.sub.2      Cl H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3 CH.sub.2      CH(CH.sub.3)CH.sub.2      CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3 CH.sub.2     CH(CH.sub.3)CH.sub.2      CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CF.sub.3 CH.sub.2     CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CF.sub.3     CH.sub.2 CH.sub.2      OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CF.sub.3 CH.sub.2     CH.sub.2 CH.sub.2 Cl H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CF.sub.3     CH.sub.2 CH.sub.2 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Br     CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.2 CH.sub.3     CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3     CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCF.sub.2 H CH.sub.2     Cl H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3 CH.sub.2 Cl H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-F CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH O     0 H -o-Cl CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH O 0 H -o-Br CH.sub.2 Cl H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-CH.sub.3 CH.sub.2 Cl H OCH.sub.3     OCH.sub.3 CH O 0 H -o-CH.sub.2 CH.sub.3 CH.sub.2      Cl H OCH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3 CH.sub.2 Cl H OCH.sub.3     OCH.sub.3 CH O 0 H -o-OCH.sub.2 CH.sub.3 CH.sub.2 Cl H OCH.sub.3     OCH.sub.3 CH O 0 H -o-CF.sub.3 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH O 0     H -o-OCF.sub.2 H CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH O 0 H -o-SCH.sub.3     CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.2 CH.sub.3     CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H .sub.--m-CH.sub.2 CH.sub.3     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.2 CH.sub.3     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.2 CH.sub.3     CH.sub.3 H CH.sub.3 CH.sub.3 N O 0 H .sub.--m-CH.sub.2 CH.sub.3 CH.sub.3     H CH.sub.3 OCH.sub.3 N O 0 H .sub.--m-CH.sub.2 CH.sub.3 CH.sub.3 H     OCH.sub.3 OCH.sub.3 N O 0 H .sub.--m-CH.sub.2 CH.sub.3 CH.sub.3 H Cl     OCH.sub.3 CH O 0 H .sub.--m-CH.sub.2 CH.sub.3 CH.sub.3 H Br OCH.sub.3 CH     O 0 H .sub.--m-CH.sub.2 CH.sub.3 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3     CH O 0 H .sub.--m-CH.sub.2 CH.sub.3 CH.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-CH.sub.2 CH.sub.3 CH.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 N O 0 H .sub.--m-CH.sub.2 CH.sub.3 CH.sub.2 CH.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.2 CH.sub.3     CH.sub.2 CH.sub.2      CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.2 CH.sub.3     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H        m     .sub.---CH.sub.2 CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2      CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.2 CH.sub.3     CH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.2     CH.sub.3 CH(CH.sub.3 ).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.s     ub.2 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-CH.sub.2 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.3 H CH.sub.3     CH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.3 H CH.sub.3     CH.sub.3 N O 0 H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.3 H CH.sub.3     OCH.sub.3 N O 0 H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.3 H OCH.sub.3     OCH.sub.3 N O 0 H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.3 H Cl OCH.sub.3 CH     O 0 H  .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.3 H Br OCH.sub.3 CH O 0 H     .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0     H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH     O 0 H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.2      CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3     CH.sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 N O 0 H .sub.--m-OCH.sub.2     CH.sub.3 CH.sub.2      CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H .sub.--m-OCH.sub.2 CH.sub.3     CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H .sub.--m-OCH.sub.2     CH.sub.3 CH.sub.2 CH.sub.3 H Cl OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2     CH.sub.3 CH.sub.2 CH.sub.3 H Br OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H        m     .sub.---OCH.sub.2 CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.2 CH.sub.2     CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O     0 H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2 H CH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.2      CH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 Cl     CH.sub.3 OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 Cl CH.sub.3 OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH O 1 H H     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 1     H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3     CH O 1 H H CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH     O 1 H H CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O     1 H H CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 1     H H CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 1     H H CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 1 H     H CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 1 H     H CH.sub.2 C(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3 CH O 1 H H CH.sub.2     C(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 CH O 1 H H CH.sub.2 CH.sub.2     OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 1 H H CH.sub.2 CH.sub.2 OCH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 1 H H CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub. 3 H     CH.sub.3 OCH.sub.3 CH O 1 H H CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 1 H H CH.sub.2 CH.sub.2 CH.sub.2 Cl H CH.sub.3     OCH.sub.3 CH O 1 H H CH.sub.2 CH.sub.2 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3     CH O 1 H H CH.sub.2 CH.sub.2 SCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 1 H H     CH.sub.2 CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 1 H H CH.sub.2     C(CH.sub.3)CH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 Ch.sub.2     OCH.sub.3 H OCH.sub.2 CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OCH.sub.3 H F OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H     OCF.sub.2 H OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.2     F OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H CF.sub.3 CF.sub.3     CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub. 3 H OCH.sub.3 H CH O 0 H H     CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.2 CH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.2 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 NH.sub.2 CH O 0 H H CH.sub.2     CH.sub.2 OCH.sub.3 H OCH.sub.3 NHCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OCH.sub.3 H OCH.sub.3 N(CH.sub.3).sub.2 CH O 0 H H CH.sub.2 CH.sub.2     OCH.sub.3 H OCH.sub.3 N(OCH.sub.3)CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OCH.sub.3 H OCH.sub.3 CH.sub.2 CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OCH.sub.3 H OCH.sub.3 SCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H     OCH.sub.3 OCH.sub.2 CHCH.sub.2 CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H     OCH.sub.3 OCH.sub.2 CCH CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H     OCH.sub.3 OCH.sub.2 CF.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H     OCH.sub.3 CN CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 N.sub.3     CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH.sub.2     SCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCF.sub.2 H     CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 SCF.sub.2 H CH O 0 H     H CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCF.sub.2 CHClF CH O 0 H H     CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCF.sub.2 CHBrF CH O 0 H H     CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCF.sub.2 CHFCF.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CHO CH O 0 H H CH.sub.2 CH.sub.2     OCH.sub.3 H OCH.sub.3 C(O)CH.sub.3 CH O 0 H H CH.sub. 2 CH.sub.2     OCH.sub.3 H OCH.sub.3 C(O)CH.sub.2 CH.sub.3 O 0 H H CH.sub.2 CH.sub.2     OCH.sub.3 H OCH.sub.3 C(O)CH.sub.2 CH.sub.2 CH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 OCH.sub.3 H OCH.sub.3 CH(OCH.sub.3).sub.2 CH O 0 H H CH.sub.2     CH.sub.2 OCH.sub.3 H OCH.sub.3 CH(SCH.sub.3).sub.2 CH O 0 H H CH.sub.2     CH.sub.2 OCH.sub.3 H OCH.sub.3 CH(OCH.sub.2 CH.sub.3).sub.2 CH O 0 H H     CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 CH(SCH.sub.2 CH.sub.2      CH.sub.3).sub.2 CH        OCH.sub.3 O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3     H OCH.sub.3 CCH.sub.3 CH        SCH.sub.3 O 0 H H CH.sub.2 CH.sub.2     OCH.sub.3 H OCH.sub.3 1,3-dioxolan- CH        2-yl O 0 H H CH.sub.2     CH.sub.2 OCH.sub.3 H OCH.sub.3 1,3-dioxolan- CH        2-yl O 0 H H     CH.sub. 2 CH.sub.2 OCH.sub.3 H OCH.sub.3 1,3-dithiolan- CH        2-yl O     0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 C(OCH.sub.3).sub.2 CH       CH.sub.2 CH.sub.2 CH.sub.3 O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H     OCH.sub.3 OCH.sub.3 CCH.sub.3 O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H     OCH.sub.3 OCH.sub.3 CCH.sub.2 CH.sub.3 O 0 H H CH.sub.2 CH.sub.2     OCH.sub.3 H OCH.sub.3 OCH.sub.3 CCl O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3     H OCH.sub.3 OCH.sub.3 CBr O 0 H H (CH.sub.2).sub.5 CH.sub.3 H CH.sub.3     CH.sub.3 CH 195-196 O 0 H H (CH.sub.2).sub.5 CH.sub.3 H CH.sub.3     OCH.sub.3 CH 196-197 O 0 H H (CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH 205-207 O 0 H H (CH.sub.2).sub.5 CH.sub.3 H CH.sub.3     OCH.sub.3 N 149-151 O 0 H H (CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3     OCH.sub.3 N 164-166 O 0 H H (CH.sub.2).sub.5 CH.sub.3 H Cl OCH.sub.3 CH     215-218 O 0 H H (CH.sub.2).sub.5 CH.sub.3 H Br OCH.sub.3 CH O 0 H H     (CH.sub.2).sub.3 CH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H     (CH.sub.2).sub.3 CH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 C(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 C(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     (CH.sub.2).sub.9 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH 172-176 O 0 H H     CH.sub.2 CH.sub.2 O(CH.sub.2).sub.9 CH.sub.3 OCH.sub.3 OCH.sub.3 CH O 0     H H CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH O 0     H H CH.sub.2 CH.sub.2 OCF.sub.2 H H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 O(CH.sub.2).sub.9 CF.sub.3 H OCH.sub. 3 OCH.sub.3 CH O     0 H H CH.sub.2 CH.sub.2 S(CH.sub.2).sub.9 CH.sub.3 H OCH.sub.3 OCH.sub.3     CH O 0 H H CH.sub.2 CH.sub.2 SCF.sub.2 H H OCH.sub.3 OCH.sub.3 CH O 0 H     H CH.sub.2 CH.sub.2 S(CH.sub.2).sub.9 CF.sub.3 H OCH.sub.3 OCH.sub.3 CH     O 0 H H CH.sub.2 CH.sub.2 SOCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 SO(CH.sub.2).sub.7 CH(CH.sub.3).sub.2 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 SOCH.sub.2 CF.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 SO.sub.2 (CH.sub.2).sub.9     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 SO.sub.2     CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OSO.sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OSO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub. 2 CH.sub.2     OSO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OSO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2     OSO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2     OSO.sub.2 CH.sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OSO.sub.2     CH.sub.3 H Br OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OSO.sub.2 CH.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OSO.sub.2     CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OSO.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 CH.sub.3 N O 0 H H CH.sub.2     CH.sub.2 OSO.sub.2 (CH.sub.2).sub.9 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O     0 H H CH.sub.2 COCH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2     COCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 COCH.sub. 3 H     OCH.sub.3 OCH.sub.3 CH 178-182 O 0 H H CH.sub.2 COCH.sub.3 H CH.sub.3     OCH.sub.3 N O 0 H H CH.sub.2 COCH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 COCH.sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2 COCH.sub.3 H Br     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 COCH.sub.3 H CH.sub.3 CH.sub.3 CH     200-201 O 0 H H CH.sub.2 CH.sub.2 COCH.sub.3 H CH.sub.3 OCH.sub.3 CH     175-180 O 0 H H CH.sub.2 CH.sub.2 COCH.sub.3 H OCH.sub.3 OCH.sub.3 CH     182-190 O 0 H H CH.sub.2 CH.sub.2 COCH.sub.3 H CH.sub.3 OCH.sub.3 N O 0     H H CH.sub.2 CH.sub.2 COCH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 CH.sub.2 COCH.sub.3 H Cl OCH.sub.3 CH 201-205 O 0 H H CH.sub.2     CH.sub.2 COCH.sub.3 H Br OCH.sub.3 CH O 0 H H CH.sub.2      COCH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2      CO(CH.sub.2).sub.9 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     COCH.sub.2 CH.sub.2 Cl H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CO(CH.sub.2).sub.5 CF.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 OCO(CH.sub.2).sub.9 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 OCOCH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 OCOCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OCOCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2      OCOCH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2      OCOCH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2      OCOCH.sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCOCH.sub.3 H     Br OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCOCH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH(CH.sub.3)OCOCH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCOCH.sub.2 Cl H     CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCOCH.sub.2 Cl H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCO(CH.sub.2).sub.9     CH.sub.2 F H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CO.sub.2      (CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CO.sub.2 CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CO.sub.2 (CH.sub.2).sub.5 CH.sub.2 Br OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CHO H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 NH.sub.2     H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 NHCH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 NHCH.sub.3 H OCH.sub.3 OCH.sub.3     CH O 0 H H CH.sub.2 CH.sub.2 NH(CH.sub.2).sub.5 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 N(CH.sub.3)CH(CH.sub.3).sub.2 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 NHCOCH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2      NHCOCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     N(CH.sub.3)COCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     N(CH.sub.3)COCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OH H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OH H CH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OH H OCH.sub.3 OCH.sub.3 CH O 0 H     H CH.sub.2 CH.sub.2 OH H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2     OH H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 OH H Cl OCH.sub.3     CH O 0 H H CH.sub.2 CH.sub.2 OH H Br OCH.sub.3 CH O 0 H H CH.sub.2     NO.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 NO.sub.2 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 NO.sub.2 H OCH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 CH.sub.2 NO.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 NO.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     NO.sub.2 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 Si(CH.sub.3).sub.2     C(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 CH      O 0 H H     ##STR60##      H OCH.sub.3 OCH.sub.3 CH      O 0 H H     ##STR61##      H OCH.sub.3 OCH.sub.3 CH      O 0 H H     ##STR62##      H OCH.sub.3 OCH.sub.3 CH      O 0 H H     ##STR63##      H OCH.sub.3 OCH.sub.3 CH      O 0 H H     ##STR64##      H OCH.sub.3 OCH.sub.3 CH      O 0 H H     ##STR65##      H OCH.sub.3 OCH.sub.3 CH      O 0 H H     ##STR66##      H CH.sub.3 CH.sub.3 CH 214-216      O 0 H H     ##STR67##      H CH.sub.3 OCH.sub.3 CH 204-207      O 0 H H     ##STR68##      H OCH.sub.3 OCH.sub.3 CH 208-210      O 0 H H     ##STR69##      H Cl OCH.sub.3 CH 228-230      O 0 H H     ##STR70##      H Br OCH.sub. 3 CH      O 0 H H     ##STR71##      H CH.sub.3 OCH.sub.3 N 201-203      O 0 H H     ##STR72##      H OCH.sub.3 OCH.sub.3 N 194-197      O 0 H H     ##STR73##      H OCH.sub.3 OCH.sub.3 CH 201-204  O 0 H H CH.sub.2 CH.sub.2 C.sub.6     H.sub.5 H CH.sub.3 CH.sub.3 CH 206-207 O 0 H H CH.sub.2 CH.sub.2 C.sub.6     H.sub.5 H CH.sub.3 OCH.sub.3 CH 188-190 O 0 H H CH.sub.2 CH.sub.2     C.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 CH 208-210 O 0 H H CH.sub.2     CH.sub.2 C.sub.6 H.sub.5 H CH.sub.3 OCH.sub.3 N 195-196 O 0 H H CH.sub.2     CH.sub.2 C.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 N 195-196 O 0 H H     CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 H Cl OCH.sub.3 CH 209-211 O 0 H H     CH.sub.2 CH.sub.2 C.sub.6 H.sub.5 H Br OCH.sub.3 CH O 0 H H CH.sub.2     CHCH(CH.sub.2).sub.6 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2  C     C(CH.sub.2).sub.6      CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H O(CH.sub.2).sub.9 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CO(CH.sub.2).sub.9 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CO.sub.2 (CH.sub.2).sub.9 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H SO.sub.2 (CH.sub.2).sub.9 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H SO.sub.2 CH(CH.sub.3).sub.2 H Cl OCH.sub.3 CH O 0 H     H CH.sub.2 CCC.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 CH O 0 H H COCH.sub.2     Cl H CH.sub.3 OCH.sub.3 CH O 0 H H COCH.sub.2 Cl H OCH.sub.3 OCH.sub.3     CH O 0 H H CO.sub.2 C.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 CH O 0 H H     SO.sub.2 C.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 CH O 0 H H COC.sub.6     H.sub.5 H OCH.sub.3 OCH.sub.3 CH 214-219 O 0 H H CHCHCH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H cyclo-     CH.sub.3 CH       propyl O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H cyclo-     CH.sub.2 CH.sub.3 CH       propyl O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H     cyclo- OCH.sub.3 CH       propyl O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H     cyclo- OCH.sub.2 CH.sub.3 CH       propyl O 0 H H CH.sub.2 CH.sub.2     OCH.sub.3 H cyclo- CH.sub.2 OCH.sub.3 CH       propyl O 0 H H CH.sub.2     CH.sub.2 OCH.sub.3 H cyclo- OCF.sub.2 H N       propyl O 0 H H CH.sub.2     CH.sub.2 OCH.sub.3 H cyclo- SCF.sub.2 H N       propyl O 0 H H CH.sub.2     CH.sub.2 OCH.sub.3 H cyclo- OCH.sub.2 CF.sub.3 CH       propyl O 0 H H     CH.sub.2 CH.sub.2 OCH.sub.3 H cyclo- CF.sub.3 N       propyl O 0 H H     CH.sub.2 CH.sub.2 OCH.sub.3 H cyclo- OCH.sub.2 CHCH.sub.2 CH     propyl O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H cyclo- OCH.sub.2 CCH N      propyl O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H cyclo- NHCH.sub.3 CH     propyl O 0 H H CH.sub.2 CH.sub.2 OCH.sub.3 H cyclo- N(CH.sub.3).sub.2 N          propyl O 0 H H CH.sub.2 CH.sub.2      OCH.sub.3 H cyclo- CH(OCH.sub.3).sub.2 CH       propyl O 0 H H CH.sub.2     CH.sub.2 CH(CH.sub.3).sub.2 H cyclo- OCH.sub.3 CH       propyl O 0 H H     CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2 H cyclo- OCH.sub.3 N       propyl O     0 H H CH.sub.2 CHCH.sub.2 H cyclo- OCH.sub.3 CH       propyl O 0 H H     CH.sub.2 CHCH.sub.2 H cyclo- OCH.sub.3 N       propyl O 0 H H CH.sub.2   C     CHHCH.sub.3 H cyclo- OCH.sub.3 CH       propyl O 0 H H CH.sub.2      CHCHCH.sub.3 H cyclo- OCH.sub.3 N       propyl O 0 H H CH.sub.2     CH.sub.2 CH.sub.2 Cl H cyclo- OCH.sub.3 CH       propyl O 0 H H CH.sub.2     CH.sub.2 CH.sub.2 Cl H cyclo- OCH.sub.3 N       propyl O 0 H H CH.sub.2     CH.sub.2 OCH.sub.3 H cyclo- OCH.sub.3 CH       propyl O 0 H H CH.sub.2     CH.sub.2 OCH.sub.3 H cyclo- OCH.sub.3 N       propyl O 0 H H CH.sub.2     CHCH.sub.2 H cyclo- OCH.sub.3 CH       propyl O 0 H H CH.sub.2      CHCH.sub.2 H cyclo- OCH.sub.3 N       propyl O 0 H H CH.sub.2      Si(CH.sub.3).sub.3 H CH.sub.3 CH.sub.3 CH 190-193 O 0 H H CH.sub.2     Si(CH.sub.3).sub.3 H Cl OCH.sub.3 CH 201-202 O 0 H H CH.sub.2      Si(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3 N 190-193 O 0 H H CH.sub.2     Si(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 N 138-141 O 0 H H (CH.sub.2).sub     .9 CH.sub.3 H CH.sub.3 CH.sub.3 CH 167-169 O 0 H H (CH.sub.2).sub.9     CH.sub.3 H CH.sub.3 OCH.sub.3 CH 159-163 O 0 H H (CH.sub.2).sub.9     CH.sub.3 H Cl OCH.sub.3 N 123-125 O 0 H H (CH.sub.2).sub.9 CH.sub.3 H     OCH.sub.3 OCH.sub. 3 N 141-145 O 0 H H CO.sub.2 CH.sub.3 H CH.sub.3     CH.sub.3 CH 218-220 O 0 H H CO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.2 CH     241-244 O 0 H H CO.sub.2 Et H OCH.sub.3 OCH.sub.3 CH 171-173 O 0 H H     CO.sub.2 Et H OCH.sub.3 CH.sub.3 CH 210-215 O 0 H H CO.sub.2 Et H     CH.sub.3 CH.sub.3 CH 185-187 O 0 H H CO.sub.2 Pr H OCH.sub.3 OCH.sub.3     CH 143-150 O 0 H H CO.sub.2 Pr H OCH.sub.3 CH.sub.3 CH 190-195 O 0 H H     CO.sub.2 Pr H CH.sub.3 CH.sub.3 CH 214-216 O 0 H H CO.sub.2 Bu H     OCH.sub.3 OCH.sub.3 CH 148-150 O 0 H H CO.sub.2 Bu H OCH.sub.3 CH.sub.3     CH 162-165 O 0 H H CO.sub.2 Bu H CH.sub.3 CH.sub.3 CH 198-202 O 0 H H     CO.sub.2 iBu H OCH.sub.3 OCH.sub.3 CH 182-186 O 0 H H CO.sub.2 iBu H     OCH.sub.3 CH.sub.3 CH 171- 174 O 0 H H CO.sub.2 iBu H CH.sub.3 CH.sub.3     CH 198-200 O 0 H H CO.sub.2 Pentyl H OCH.sub.3 OCH.sub.3 147-149 O 0 H H     CO.sub.2 Pentyl H OCH.sub.3 CH.sub.3 CH 140-148 O 0 H H CO.sub.2 Pentyl     H CH.sub.3 CH.sub.3 CH 175-176 O 0 H H CO.sub.2 Hexyl H OCH.sub.3     OCH.sub.3 CH 130-135 O 0 H H CO.sub.2 Hexyl H OCH.sub.3 OCH.sub.3 CH     155-156 O 0 H H CO.sub.2 Hexyl H OCH.sub.3 OCH.sub.3 CH 166-168 O 0 H H     CO.sub.2 CH.sub.2 Ph H OCH.sub.3 OCH.sub.3 CH 188-190 O 0 H H CO.sub.2     CH.sub.2 Ph H OCH.sub.3 OCH.sub.3 CH 194-197 O 0 H H CO.sub.2 CH.sub.2     Ph H OCH.sub.3 OCH.sub.3 CH 173-179 O 0 H H CO.sub.2 -.sub.-i-Pr H     OCH.sub.3 OCH.sub.3 CH 210-215 O 0 H H CO.sub.2 -.sub.-i-Pr H CH.sub.3     OCH.sub.3 CH 219-224 O 0 H H CO.sub.2 -.sub.-i-Pr H Cl OCH.sub.3 CH     194-199 O 0 H H CO.sub.2 C(CH.sub.3).sub.3 H CH.sub.3 CH.sub.3 CH O 0 H     H CO.sub.2 C(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CO.sub.2     C(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CO.sub.2      C(CH.sub.3).sub.3 H Cl OCH.sub.3 CH O 0 H H CO.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH 239-241 O 0 H H CO.sub.2 CH.sub.3 H Cl OCH.sub.3     CH 238-241 O 0 H H CO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 N 217-219 O 0     H H CO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N 219-220 O 0 H H CH.sub.2     CH.sub.2 CO.sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 CO.sub.2 CH.sub.3 H Cl OCH.sub.3 CH 219-223 O 0 H H CH.sub.2     CH.sub.2 CO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 N 197-199 O 0 H H     CH.sub.2 CH.sub.2 CO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N 183-189 O 0     H H CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H     CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2     OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH     O 0 H H CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3     CH.sub.3 CH O 0 H H CH.sub.2 CH(CH.sub.2 CH.sub.3).sub.2 H CH.sub.3     CH.sub.3 CH O 0 H H CH.sub.2 CH(CH.sub.2 CH.sub.3).sub.2 H CH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH(CH.sub.2 CH.sub.3).sub.2 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH(CH.sub.2 CH.sub.3).sub.2 H Cl OCH.sub.3     CH O 0 H H CH.sub.2 CH(CH.sub.2 CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 N O     0 H H CH.sub.2 CH(CH.sub.2 CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 N O 0 H     H CH(CH.sub.2 CH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CH 209-211 O 0 H H     CH(CH.sub.2 CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH 219-225 O 0 H H     CH(CH.sub.2 CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH 223-225 O 0 H H     CH(CH.sub.2      CH.sub.3).sub.2 H Cl OCH.sub.3 CH 220-223 O 0 H H CH(CH.sub.2      CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 N 149-152 O 0 H H CH(CH.sub.2     CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 N 139-143 O 0 H H CH.sub.2     CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 N O 0 H H     CH.sub.2 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH(CH.sub.3)CH.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2      CH(CH.sub.3)CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH O     0 H H CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.2     CH.sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH(CH.sub.3)CH.sub.2     CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2      CH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O     0 H H CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 H Cl     OCH.sub.3 CH O 0 H H CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 OCH.sub.2 OCH.sub.3 H     CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.2 OCH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.2 OCH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.2 OCH.sub.3 H     Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.2 OCH.sub. 3 H     CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 OCH.sub.2 OCH.sub.3 H     OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 OCH.sub.2 CHOCH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.2 CHOCH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 I H CH.sub.3     CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 I H CH.sub.3 OCH.sub.3 CH     O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 I H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 CH.sub.2 I H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     CH.sub.2 I H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 I H     OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl H     CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl H     CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl H     Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl H     CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Cl H     OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Br H     CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Br H     CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Br H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Br H     Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Br H     CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Br H     OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 F H CH.sub.3     CH.sub.3 CH 210-211 O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 F H CH.sub.3     OCH.sub.3 CH 216-217 O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3     OCH.sub.3 CH 199-200 O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 F H Cl OCH.sub.3     CH 222-224 O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 F H CH.sub.3 OCH.sub.3 N     148-149 O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 N     182-184 O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 F H CH.sub.3     CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 F H CH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2      F H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 F H     CH.sub.3 OCH.sub.3 N O 0 H H CH.sub. 2 CH.sub.2 CH.sub.2 CH.sub.2 F H     OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CF.sub.3 H CH.sub.3     CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CF.sub.3 H CH.sub.3 OCH.sub.3 CH O     0 H H CH.sub.2 CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 CF.sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     CF.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CF.sub.3 H     OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CF.sub.3 H     CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CF.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CF.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CF.sub.3 H Cl     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CF.sub.3 H CH.sub.3     OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CF.sub.3 H OCH.sub.3     OCH.sub.3 N O 0 H H CH.sub.2 CH(CF.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH     O 0 H H CH.sub.2 CH(CF.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CH 190-192 O 0 H H CH.sub.2     OCH.sub.3 H Cl OCH.sub.3 CH 172-174 O 0 H H CH.sub.2 OCH.sub.3 H     CH.sub.3 OCH.sub.3 N 171-173 O 0 H H CH.sub.2 OCH.sub.3 H OCH.sub.3     OCH.sub.3 N 116-119 O 0 H H CH.sub.2 OCH.sub.2 CH.sub.3 H CH.sub.3     CH.sub.3 CH O 0 H H CH.sub.2 OCH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH     O 0 H H CH.sub.2 OCH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 OCH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2     CH.sub. 2 CH.sub.2 OCH.sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2     CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2      C(OCH.sub.3).sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2     C(OCH.sub.3).sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     C(OCH.sub.3).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     C(OCH.sub.3).sub.2 CH.sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2      C(OCH.sub.3).sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     C(OCH.sub.3).sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     CH.sub.2 C(OCH.sub.3).sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 C(OCH.sub.3).sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O     0 H H CH.sub.2 CH.sub. 2 C(OCH.sub.3).sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 C(OCH.sub.3).sub.2 CH.sub.3 H Cl     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 C(OCH.sub.3).sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 C(OCH.sub.3).sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2      OCH.sub.2CH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OCH.sub.2CH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OCH.sub.2CH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OCH.sub.2CH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OCH.sub.2CH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OCH.sub.2CH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H (2-cyclopentoxy)ethyl     H CH.sub.3 OCH.sub.3 CH O 0 H H (2-cyclopentoxy)ethyl H OCH.sub.3     OCH.sub. 3 CH O 0 H H phenoxymethyl H CH.sub.3 OCH.sub.3 CH O 0 H H     phenoxymethyl H OCH.sub.3 CH.sub.3 CH O 0 H H 2-phenoxyethyl H CH.sub.3     OCH.sub.3 CH O 0 H H 2-phenoxyethyl H OCH.sub.3 OCH.sub.3 CH O 0 H H     (4-chlorophenoxy)methyl H OCH.sub.3 OCH.sub.3 CH O 0 H H (4-chlorophenoxy     )methyl H OCH.sub.3 OCH.sub.3 CH O 0 H H (4-chlorophenoxy)methyl H     OCH.sub.3 OCH.sub.3 CH O 0 H H (4-chlorophenoxy)methyl H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCH.sub.2 CCH.sub.2      (CH.sub.2).sub.6 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 OCH.sub.2 CCH.sub.2 (CH.sub.2).sub.6 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OC(O)CH.sub.2 CHCH.sub.2 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OC(O)CCCH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OC(O)(cyclopropyl) H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OC(O)C.sub. 6 H.sub.5 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OC(O)C.sub.6 H.sub.5 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OC(O)NHCH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OC(O)NHCH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OC(O)NHCH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OC(O)N(CH.sub.3).sub.2 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OC(O)NH(CH.sub.2).sub.3     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2      OC(O)NHC.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 OSO.sub.2 CF.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 OSO.sub.2 C.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 OP(O)(OCH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H     H CH.sub.2 CH.sub.2 OP(O)(OCH.sub.2 CH.sub.2 CH.sub. 2 CH.sub.2) H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 P(O)(OCH.sub.3).sub.2 H CH.sub.3     CH.sub.3 CH O 0 H H CH.sub.2 P(O)(OCH.sub.3).sub.2 H CH.sub.3 OCH.sub.3     CH O 0 H H CH.sub.2 P(O)(OCH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H     H CH.sub.2 P(O)(OCH.sub.3).sub.2 H Cl OCH.sub.3 CH O 0 H H CH.sub.2     P(O)(OCH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2      P(O)(OCH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2     OCO.sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OCO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OCO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OCO.sub.2 CH.sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OCO.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 OCO.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 OCO.sub.2     CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OCO.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 OCO.sub.2 C.sub.6 H.sub.5 H CH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 OCO.sub.2 C.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 CH O 0     H H CH.sub.2 CH.sub.2 OP(S)(OCH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O     0 H H CH.sub.2 CH.sub.2 OP(S)(OCH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH     O 0 H H CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3 H CH.sub.3 CH.sub.3 CH O 0     H H CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H     H CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 OSi(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     CH.sub.2 OSi(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     CH.sub.2 OSi(CH.sub.3).sub.2 C(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3 CH O     0 H H CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.2      C(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     OSi(CH.sub.3).sub.2 (CH.sub.2).sub.9 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O     0 H H CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.2 C.sub.6 H.sub.5 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.2 CH.sub.2     C.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     CH.sub.2 OH H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 OH     H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2      OH H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 OH H     OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 OH H Cl     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2      OC(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     CH.sub.2 OCi(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 CH.sub.2 OSO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 SO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     SO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 SO.sub.2     CH.sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2 SO.sub.2 CH.sub.3 H CH.sub.3     OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 SOCH.sub.2 CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 SOCH.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 SC.sub.6 H.sub.5 H     CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 SC.sub.6 H.sub.5 H CH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 SC.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 CH     O 0 H H CH.sub.2 SC.sub.6 H.sub.5 H Cl OCH.sub.3 CH O 0 H H CH.sub.2     SC.sub.6 H.sub.5 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 SC.sub.6     H.sub.5 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 SO.sub.2 C.sub.6     H.sub.5 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 SO.sub.2 C.sub.6     H.sub.5 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 SO.sub.2 C.sub.6     H.sub.5 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 SO.sub.2 C.sub.6 H.sub.5     H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 SCN H CH.sub.3 OCH.sub.3 CH O 0     H H CH.sub.2 SCN H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 SCN     H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 SCN H OCH.sub.3     OCH.sub.3 CH 193-195 O 0 H H CH.sub.2 CN H CH.sub.3 CH.sub.3 CH 230-234     O 0 H H CH.sub.2 CN H Cl OCH.sub.3 CH 238-241 O 0 H H CH.sub.2 CN H     CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CN H OCH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 CH.sub.2 SP(O)(OCH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H     H CH.sub.2 CH.sub.2 SP(S)(OCH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0     H H CH.sub.2 P(S).sub.2 (OCH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H     H CH.sub.2 NH.sub.2 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 NH.sub.2 H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 NH CH.sub. 2 CH.sub.2 CH.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 N.sup.⊕      (CH.sub.3).sub.3 Cl.sup.⊖ H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 N.sup.⊕ (CH.sub.3).sub.3 I.sup.⊕ H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 NHCO.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 NHC(O)NH CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 NHC(O)NH CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3 H CH.sub.3     CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 NHSO.sub.2      CH.sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 NHSO.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2      NHP(O)(OCH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 NHP(S)(OCH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 NO.sub.2 H Cl CH.sub.3 CH O 0 H H CH.sub.2 NO.sub.2 H OCH.sub.3     OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 NO.sub.2 H CH.sub.3 CH.sub.3 CH O     0 H H CH.sub.2 CH.sub.2 NO.sub.2 H Cl OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 NO.sub.2 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 C(O)C.sub.6     H.sub.5 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 C(O)C.sub.6 H.sub.5 H     CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 C(O)C.sub.6 H.sub.5 H OCH.sub.3     OCH.sub.3 CH 193-199 O 0 H H CH.sub.2 C(O)C.sub.6 H.sub.5 H Cl OCH.sub.3     CH O 0 H H CH.sub.2 C(O)C.sub.6 H.sub.5 H CH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 C(O)C.sub.6 H.sub. 5 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     CH.sub.2 C(O)C.sub.6 H.sub.5 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 C(O)C.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CO.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2     CO.sub.2 CH.sub.2 CH.sub.3 H Cl OCH.sub.3 CH 164-166 O 0 H H CH.sub.2     CO.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     CO.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     CO.sub.2 C.sub.6 H.sub.5 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2     CO.sub.2 C.sub.6 H.sub.5 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CO.sub.2 C.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CO.sub.2 C.sub.6 H.sub.5 H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CO.sub.2     C.sub.6 H.sub.5 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CO.sub.2 C.sub.6     H.sub.5 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CO.sub.2     CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     CO.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 CO.sub.2 C.sub.6 H.sub.5 H CH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 CO.sub.2 C.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 CH O 0     H H CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3 CH 168-172 O 0     H H CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 CH 178-180     O 0 H H CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3 H Cl OCH.sub.3 CH 156-159 O     0 H H CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 CO.sub.2 H H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CO.sub.2 H H     CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CO.sub.2 H H OCH.sub.3 OCH.sub.3     CH O 0 H H CH.sub.2 CO.sub.2 H H Cl OCH.sub.3 CH O 0 H H CH.sub.2     CO.sub.2 H H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CO.sub.2      H H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH(CH.sub.3)CN H CH.sub.3     CH.sub.3 CN O 0 H H CH.sub.2 CH(CH.sub.3)CN H Cl OCH.sub.3 CH O 0 H H     CH.sub.2 CH(CH.sub.3)CN H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2      CH(CH.sub.3)CN H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 C(O)NHCH.sub.3     H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 C(O)NHCH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2      C(O)N(CH.sub.3 ).sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     C(O)N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H (1-naphthyl)methyl      H CH.sub.3 OCH.sub.3 CH 163-169 O 0 H H (1-naphthyl)methyl H OCH.sub.3     OCH.sub.3 CH 220-228 O 0 H H (2-naphthyl)methyl H CH.sub.3 OCH.sub.3 CH     O 0 H H (2-naphthyl)methyl H OCH.sub.3 OCH.sub.3 CH O 0 H H (2-methylpyri     dinium)- H CH.sub.3 OCH.sub.3 CH     methyl iodide O 0 H H (2-methylpyrid     inium)- H OCH.sub.3 OCH.sub.3 CH     methyl iodide O 0 H H pyridin-2-ylme     thyl H CH.sub.3 CH.sub.3 CH O 0 H H pyridin-2-ylmethyl H CH.sub.3     OCH.sub.3 CH O 0 H H pyridin-2-ylmethyl H OCH.sub.3 OCH.sub.3 CH 172-174     O 0 H H pyridin-2-ylmethyl H Cl OCH.sub.3 CH O 0 H H pyridin-2-ylmethyl     H CH.sub.3 OCH.sub.3 N O 0 H H pyridin-2-ylmethyl H OCH.sub.3 OCH.sub.3     N O 0 H H pyridin-3-ylmethyl H CH.sub.3 CH.sub.3 CH O 0 H H pyridin-3-ylm     ethyl H CH.sub.3 OCH.sub.3 CH O 0 H H pyridin-3-ylmethyl H OCH.sub.3     OCH.sub.3 CH O 0 H H pyridin-3-ylmethyl H Cl OCH.sub.3 CH O 0 H H     pyridin-3-ylmethyl H CH.sub.3 OCH.sub.3 N O 0 H H pyridin-3-ylmethyl H     OCH.sub.3 OCH.sub.3 N O 0 H H pyridin-4-ylmethyl H CH.sub.3 CH.sub.3 CH     O 0 H H pyridin-4-ylmethyl H CH.sub.3 OCH.sub.3 CH O 0 H H pyridin-4-ylme     thyl H OCH.sub.3 OCH.sub.3 CH O 0 H H pyridin-4-ylmethyl H Cl OCH.sub.3     CH O 0 H H pyridin-4-ylmethyl H CH.sub.3 OCH.sub.3 N O 0 H H pyridin-4-yl     methyl H OCH.sub.3 OCH.sub.3 N O 0 H H thien-2-ylmethyl H CH.sub.3     CH.sub.3 CH O 0 H H thien-2-ylmethyl H CH.sub.3 OCH.sub.3 CH O 0 H H     thien-2-ylmethyl H OCH.sub.3 OCH.sub.3 CH O 0 H H thien-2-ylmethyl H Cl     OCH.sub.3 CH O 0 H H thien-2-ylmethyl H CH.sub.3 OCH.sub.3 N O 0 H H     thien-2-ylmethyl H OCH.sub.3 OCH.sub.3 N O 0 H H thien-3-ylmethyl H     CH.sub.3 CH.sub.3 CH

      W n R R.sub.1 R.sub.2 R.sub.3 X Y Z m.p. (°C.)       O 0 H H thien-3-ylmethyl H CH.sub.3 OCH.sub.3 CH  O 0 H H thien-3-ylmet     hyl H OCH.sub.3 OCH.sub.3 CH O 0 H H thien-3-ylmethyl H H Cl OCH.sub.3     CH O 0 H H thien-3-ylmethyl H CH.sub.3 OCH.sub.3 N O 0 H H thien-3-ylmeth     yl H OCH.sub.3 OCH.sub.3 N O 0 H H (5-methylthien-2-yl)methyl H CH.sub.3     OCH.sub.3 CH O 0 H H (5-methylthien-2-yl)methyl H OCH.sub.3 OCH.sub.3 CH     O 0 H H (5-chlorothien-2-yl)methyl H CH.sub.3 OCH.sub.3 CH O 0 H H     (5-chlorothien-2-yl)methyl H OCH.sub.3 OCH.sub.3 CH O 0 H H (5-cyanothien     -2-yl)methyl H CH.sub.3 OCH.sub.3 CH O 0 H H (5-cyanothien-2-yl)methyl H     OCH.sub.3 OCH.sub.3 CH O 0 H H furan-2-ylmethyl H CH.sub.3 OCH.sub.3 CH     O 0 H H furan-2-ylmethyl H OCH.sub.3 OCH.sub.3 CH O 0 H H (5-methylfuran-     2-yl)methyl H CH.sub.3 OCH.sub.3 CH O 0 H H (5-methylfuran-2-yl)methyl H     OCH.sub. 3 OCH.sub.3 CH O 0 H H furan-3-ylmethyl H CH.sub.3 OCH.sub.3 CH     O 0 H H furan-3-ylmethyl H OCH.sub.3 OCH.sub.3 CH O 0 H H (4.5-dihydrofur     an-2-yl)methyl H CH.sub.3 OCH.sub.3 CH O 0 H H (4.5-dihydrofuran-2-yl)met     hyl H OCH.sub.3 OCH.sub.3 CH O 0 H H (1H-pyrrol-1-yl)methyl H CH.sub.3     OCH.sub.3 CH O 0 H H (1H-pyrrol-1-yl)methyl H OCH.sub.3 OCH.sub.3 CH O 0     H H (1H-pyrrol-2-yl)methyl H CH.sub.3 OCH.sub.3 CH O 0 H H (1H-pyrrol-2-y     l)methyl H OCH.sub.3 OCH.sub.3 CH O 0 H H (1-methyl-1H-pyrrol-3-yl)methyl      H CH.sub.3 OCH.sub.3 CH O 0 H H (1-methyl-1H-pyrrol-3-yl)methyl H     OCH.sub.3 OCH.sub.3 CH O 0 H H oxazol-2-ylmethyl H CH.sub.3 OCH.sub.3 CH     O 0 H H oxazol-2-ylmethyl H OCH.sub.3 OCH.sub.3 CH O 0 H H thiazol-2-ylme     thyl H CH.sub.3 OCH.sub.3 CH O 0 H H thiazol-2-ylmethyl H OCH.sub.3     OCH.sub.3 CH O 0 H H (4.5-dihydro-4.4-dimethyl- H CH.sub.3 OCH.sub.3 CH        oxazol-2-yl)methyl O 0 H H (4.5-dihydro-4.4-dimethyl- H OCH.sub.3     OCH.sub.3 CH     oxazol-2-yl)methyl O 0 H H isoxazol-3-ylmethyl H     CH.sub.3 OCH.sub.3 CH O 0 H H isoxazol-3-ylmethyl H OCH.sub.3 OCH.sub.3     CH O 0 H H (1,2,4-oxadiazol-3-yl)methyl H CH.sub.3 OCH.sub.3 CH O 0 H H     (1,2,4-oxadiazol-3-yl)methyl H OCH.sub.3 OCH.sub.3 CH O 0 H H (5-methyl-1     ,2,4-oxadiazol- H CH.sub.3 OCH.sub.3 CH     3-yl)methyl O 0 H H (5-methyl     -1,2,4-oxadiazol- H OCH.sub.3 OCH.sub.3 CH     3-yl)methyl O 0 H H     (5-methyl-1,3,4-oxadiazol- H CH.sub.3 OCH.sub.3 CH     2-yl)methyl O 0 H     H (5-methyl-1,3,4-oxadiazol- H OCH.sub.3 OCH.sub.3 CH     2-yl)methyl O     0 H H 1H-pyrazol-1-ylmethyl H CH.sub.3 OCH.sub.3 CH O 0 H H 1H-pyrazol-1-     ylmethyl H OCH.sub.3 OCH.sub.3 CH O 0 H H 4H-pyrazol-1-ylmethyl H     CH.sub.3 OCH.sub.3 CH O 0 H H 1H-1,2,4,triazol-1-ylmethyl H CH.sub.3     OCH.sub.3 CH O 0 H H 1H-1,2,4,triazol-1-ylmethyl H OCH.sub.3 OCH.sub.3     CH O 0 H H (1-methyl-1H-imidazol- H CH.sub.3 OCH.sub.3 CH     2-yl)methyl      O 0 H H (1-methyl-1H-imidazol- H OCH.sub.3 OCH.sub.3 CH     2-yl)methyl     O 0 H H (1-methyl-1H-1,2,4- H CH.sub.3 OCH.sub.3 CH     triazol-5-yl)meth     yl O 0 H H (1-methyl-1H-1,2,4- H OCH.sub.3 OCH.sub.3 CH     triazol-5-yl)     methyl O 0 H H (4,5-dihydro-1,4,4-trimethyl- H CH.sub.3 OCH.sub.3 CH     1H-imidazol-2-yl)methyl O 0 H H (4,5-dihydro-1,4,4-trimethyl- H OCH.sub.3      OCH.sub.3 CH     1H-imidazol-2-yl)methyl O 0 H H (1,2,5-thiadiazol-3-yl)     methyl H CH.sub.3 OCH.sub.3 CH O 0 H H (1,2,5-thiadiazol-3-yl)methyl H     OCH.sub.3 OCH.sub.3 CH O 0 H H 4-(2,6-dimethylmorpholino) H CH.sub.3     OCH.sub.3 CH     methyl O 0 H H 4-(2,6-dimethylmorpholino) H OCH.sub.3     OCH.sub.3 CH     methyl O 0 H H (4,6-dimethoxy-1,3,5- H CH.sub.3     OCH.sub.3 CH     triazin-2-yl)methyl O 0 H H (4,6-dimethoxy-1,3,5- H     OCH.sub.3 OCH.sub.3 CH     triazin-2-yl)methyl O 0 H H (4-dimethyamino-6-     methylthio H CH.sub.3 OCH.sub.3 CH     1,3,5-triazin-2-yl)methyl O 0 H H     (4-dimethyamino-6-methylthio H OCH.sub.3 OCH.sub.3 CH     1,3,5-triazin-2     -yl)methyl O 0 H H (cyclopentanon-2-yl)methyl H CH.sub.3 CH.sub.3 CH O 0     H H (cyclopentanon-2-yl)methyl H CH.sub.3 OCH.sub.3 CH O 0 H H (cyclopent     anon-2-yl)methyl H OCH.sub.3 OCH.sub.3 CH O 0 H H (cyclopentanon-2-yl)met     hyl H Cl OCH.sub.3 CH O 0 H H (cyclopentanon-2-yl)methyl H CH.sub.3     OCH.sub.3 N O 0 H H (cyclopentanon-2-yl)methyl H OCH.sub.3 OCH.sub.3 N O     0 H H γ     butyryllactone-2-yl)- H CH.sub.3 CH.sub.3 CH     methyl O 0 H H γ     butyryllactone-2-yl)- H CH.sub.3 OCH.sub.3 CH     methyl O 0 H H     γ butyryllactone-2-yl)- H OCH.sub.3 OCH.sub.3 CH     methyl O 0 H     H γ     butyryllactone-2-yl)- H Cl OCH.sub.3 CH     methyl O 0 H H γ     butyryllactone-2-yl)- H CH.sub.3 OCH.sub.3 N     methyl O 0 H H γ     butyryllactone-2-yl)- H OCH.sub.3 OCH.sub.3 N     methyl O 0 H H     γ butyryllactone-3-yl)- H CH.sub.3 CH.sub.3 CH     methyl O 0 H H     γ     butyryllactone-3-yl)- H CH.sub.3 OCH.sub.3 CH     methyl O 0 H H     γ butyryllactone-3-yl)- H OCH.sub.3 OCH.sub.3 CH     methyl O 0 H     H γ     butyryllactone-3-yl)- H Cl OCH.sub.3 CH     methyl O 0 H H γ     butyryllactone-3-yl)- H CH.sub.3 OCH.sub.3 N     methyl O 0 H H γ     butyryllactone-3-yl)- H OCH.sub.3 OCH.sub.3 N     methyl O 0 H H     cyclohexanon-2-yl)methyl H CH.sub.3 CH.sub.3 CH O 0 H H (cyclohexanon-2-y     l)methyl H CH.sub.3 OCH.sub.3 CH O 0 H H (cyclohexanon-2-yl)methyl h     OCH.sub.3 OCH.sub.3 CH O 0 H H (cyclohexanon-2-yl)methyl H Cl OCH.sub.3     CH O 0 H H (cyclohexanon-2-yl)methyl H CH.sub.3 OCH.sub.3 N O 0 H H     (cyclohexanon-2-yl)methyl H OCH.sub.3 OCH.sub.3 N O 0 H H 2-chloro-6-fluo     robenzyl H OCH.sub.3 OCH.sub.3 CH O 0 H H 4-methylthiobenzyl H OCH.sub.3     OCH.sub.3 CH O 0 H H 4-methylsulfonylbenzyl H OCH.sub.3 OCH.sub.3 CH O 0     H H 1,1'-biphenylmethyl H OCH.sub.3 OCH.sub.3 CH O 0 H H 3-phenoxybenzyl     H OCH.sub.3 OCH.sub.3 CH O 0 H H 2-[4-(2,2-dimethyl-1,3- H OCH.sub.3     OCH.sub.3 CH     dioxolan-2-yl)methoxy]ethyl O 0 H H 4-(2,2-dimethyl-1,3-      H OCH.sub.3 OCH.sub.3 CH     dioxolan-2-yl)methoxy O 0 H H (2-methyl-1,3     -dioxolan-2- H CH.sub.3 OCH.sub.3 CH     yl)methyl O 0 H H (2-methyl-1,3-     dioxolan-2- H OCH.sub.3 OCH.sub.3 CH     yl)methyl O 0 H H 2-(2-methyl-1,     3-dioxolan- H CH.sub.3 OCH.sub.3 CH     2-yl)methyl O 0 H H 2-(2-methyl-1     ,3-dioxolan- H OCH.sub.3 OCH.sub.3 CH     2-yl)methyl O 0 H H (1,3-dioxol     an-2-yl)methyl H CH.sub.3 OCH.sub.3 CH O 0 H H (1,3-dioxolan-2-yl)methyl     H OCH.sub.3 OCH.sub.3 CH O 0 H H 2-(1,3-dioxolan-2-yl)methyl H CH.sub.3     OCH.sub.3 CH O 0 H H 2-(1,3-dioxolan-2-yl)methyl H OCH.sub.3 OCH.sub.3     CH O 0 H H (1,3-dioxolan-2-yl)methyl H CH.sub.3 OCH.sub.3 CH O 0 H H     (1,3-dioxolan-2-yl)methyl H OCH.sub.3 OCH.sub.3 CH O 0 H H 2-(2-tetrahydr     opyranyloxy) H CH.sub.3 OCH.sub.3 CH     ethyl O 0 H H 2-(2-tetrahydropyr     anyloxy) H OCH.sub.3 OCH.sub.3 CH     ethyl O 0 H H CH.sub.2      C(CH.sub.3)NOH H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 C(CH.sub.3)NOH     H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CHC(CH.sub.3)NOH H CH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CHC(CH.sub.3)NOH H OCH.sub.3 OCH.sub.3 CH     O 0 H H CH.sub.2      C(CH.sub.3)(CN)OSi(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH(C.sub.6 H.sub.5).sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H CH(C.sub.6     H.sub.5).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH(CN).sub.2 H CH.sub.3     OCH.sub.3 CH O 0 H H CH(CN).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H     C(Cl)CHCl H CH.sub.3 OCH.sub.3 CH O 0 H H C(Cl)CHCl H OCH.sub.3 OCH.sub.3      CH O 0 H H CHCHC(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH OO 0 H H CHCHCN H     OCH.sub.3 OCH.sub.3 CH O 0 H H CHCHCO.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CHCHCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H     CHCHCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CHCHCH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H H CHCHCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     2-epoxypropyl H CH.sub.3 CH.sub.3 CH O 0 H H 2-epoxypropyl H Cl OCH.sub.3      CH O 0 H H 2-epoxypropyl H CH.sub.3 OCH.sub.3 N O 0 H H 2-epoxypropyl H     OCH.sub.3 OCH.sub.3 N O 0 H H 2-epoxtbutyl H CH.sub.3 CH.sub.3 CH O 0 H     H 2-epoxybutyl H CH.sub.3 OCH.sub.3 CH O 0 H H 2-epoxybutyl H OCH.sub.3     OCH.sub.3 CH O 0 H H 2-epoxybutyl H Cl OCH.sub.3 CH O 0 H H 2-epoxybutyl     H CH.sub.3 OCH.sub.3 N O 0 H H 2-epoxybutyl H OCH.sub.3 OCH.sub.3 N O 0     H H (4-t-butylcyclohexyl)methyl H OCH.sub.3 OCH.sub.3 CH O 0 H H     (4-chlorocyclopentyl)methyl H OCH.sub.3 OCH.sub.3 CH O 0 H H C.sub.6     H.sub.5 H CH.sub.3 CH.sub.3 CH O 0 H H C.sub.6 H.sub.5 H CH.sub.3     OCH.sub.3 CH O 0 H H C.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 CH O 0 H H     C.sub.6 H.sub.5 H Cl OCH.sub.3 CH O 0 H H C.sub.6 H.sub.5 H CH.sub. 3     OCH.sub.3 N O 0 H H C.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 N O 0 H H     .sub.--PNO.sub.2 C.sub.6 H.sub.4 H CH.sub.3 OCH.sub.3 CH O 0 H H         N     .sub.--PO.sub.2 C.sub.6 H.sub.4 H OCH.sub.3 OCH.sub.3 CH 193-194 O 0 H H     .sub.--PCNC.sub.6      H.sub.4 H CH.sub.3 OCH.sub.3 CH O 0 H H .sub.--PCNC.sub.6 H.sub.4 H     OCH.sub.3 OCH.sub.3 CH O 0 H H .sub.--PCH.sub.3 SO.sub.2 C.sub.6 H.sub.4     H CH.sub.3 OCH.sub.3 CH O 0 H H .sub.--PCH.sub.3 SO.sub.2 C.sub.6     H.sub.4 H OCH.sub.3 OCH.sub.3 CH O 0 H H .sub.--PClC.sub.6 H.sub.4 H     CH.sub.3 OCH.sub.3 CH O 0 H H .sub.--PClC.sub.6 H.sub.4 H OCH.sub.3     OCH.sub.3 CH O 0 H H 4-pyrimidinyl H CH.sub.3 OCH.sub.3 CH O 0 H H     4-pyrimidinyl H OCH.sub.3 OCH.sub.3 CH O 0 H H 2-pyrimidinyl H CH.sub.3     OCH.sub.3 CH O 0 H H 2-pyrimidinyl H OCH.sub.3 OCH.sub.3 CH O 0 H H     2-thienyl H OCH.sub.3 OCH.sub.3 CH O 0 H H 3-thienyl H OCH.sub.3     OCH.sub.3 CH O 0 H H 2-thiazolyl H OCH.sub.3 OCH.sub.3 CH O 0 H H     1-methyl-1H-imidazol-2-yl H OCH.sub.3 OCH.sub.3 CH O 0 H H 2-oxazolyl H     OCH.sub.3 OCH.sub.3 CH O 0 H H 2-(5-nitrothienyl) H CH.sub.3 OCH.sub.3     CH O 0 H H pyrimidin-2-yl H CH.sub.3 OCH.sub.3 CH O 0 H H 4,6-dimethoxypy     rimidin- H CH.sub.3 OCH.sub.3 CH     2-yl O 0 H H 2-cyclopentanonyl H     CH.sub.3 OCH.sub.3 CH O 0 H H 2-cyclopentanonyl H OCH.sub.3 OCH.sub.3 CH     O 0 H H 3-cyclopentanonyl H CH.sub.3 OCH.sub.3 CH O 0 H H 3-cyclopentanon     yl H OCH.sub.3 OCH.sub.3 CH O 0 H H 2-cyclohexanonyl H CH.sub.3 OCH.sub.3      CH O 0 H H 2-cyclohexanonyl H OCH.sub.3 OCH.sub.3 CH O 0 H H 3-cyclohexa     nonyl H CH.sub.3 OCH.sub.3 CH O 0 H H 3-cyclohexanonyl H OCH.sub.3     OCH.sub.3 CH O 0 H H γ     butyrolactone- H CH.sub.3 OCH.sub.3 CH     2-yl O 0 H H γ     butyrolactone- H OCH.sub.3 OCH.sub.3 CH 206-211     2-yl O 0 H H     γ butyrolactone- H CH.sub.3 OCH.sub.3 CH     3-yl O 0 H H γ     butyrolactone- H OCH.sub.3 OCH.sub.3 CH     3-yl O 0 H H SCH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H H SCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     SCH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H SCH.sub.2     CH.sub.2 CH.sub.3 CH H OCH.sub.3 OCH.sub.3 CH O 0 H H S(CH.sub.2).sub.9     CH H OCH.sub.3 OCH.sub.3 CH O 0 H H SCCl.sub.3 H CH.sub.3 CH.sub.3 CH O     0 H H SCCl.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H SCCl.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H SCCl.sub. 3 H Cl OCH.sub.3 CH O 0 H H SCCl.sub.3 H     CH.sub.3 OCH.sub.3 N O 0 H H SCCl.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H     SC.sub.6 H.sub.5 H CH.sub.3 OCH.sub.3 CH O 0 H H SC.sub.6 H.sub.5 H     OCH.sub.3 OCH.sub.3 CH O 0 H H 4-nitrophenylthio H CH.sub.3 OCH.sub.3 CH     O 0 H H 4-nitrophenylthio H OCH.sub.3 OCH.sub.3 CH O 0 H H SO.sub.2     CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H SO.sub.2 CH.sub.3 H Cl OCH.sub.3     CH O 0 H H SO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H SO.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H SO.sub.2 CH.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H H SO.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H SO.sub.2 CH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH     O 0 H H SO.sub.2 CH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H     phenylsulfonyl H CH.sub.3 OCH.sub.3 CH O 0 H H phenylsulfonyl H OCH.sub.3      OCH.sub.3 CH O 0 H H OCH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H OCH.sub.3     H Cl OCH.sub.3 CH O 0 H H OCH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H     OCH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H OH H CH.sub.3 OCH.sub.3 N O 0     H H OH H OCH.sub.3 OCH.sub.3 N O 0 H H OCH.sub.2 CH.sub.2 CH.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H OCH.sub.2 CH.sub.2 CH.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H C(O)CH.sub.3 H CH.sub.3     CH.sub.3 CH 227-228 O 0 H H C(O)CH.sub.3 H Cl OCH.sub.3 CH 218-220 O 0 H     H C(O)CH.sub.3 H Br OCH.sub.3 CH O 0 H H C(O)CH.sub.3 H CH.sub.3     OCH.sub.3 N 195-197 O 0 H H C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 N 199-201     O 0 H H C(O)CH.sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH 190-191 O 0 H H     C(O)CH.sub.2 CH.sub.3 H Cl OCH.sub.3 CH 203-205 O 0 H H C(O)CH.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 N 185-186 O 0 H H C(O)CH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 N 189-190 O 0 H H C(O)CH.sub.2 CH.sub.2 CH.sub.3 H     CH.sub.3 CH.sub.3 CH 196-198 O 0 H H C(O)CH.sub.2 CH.sub.2 CH.sub.3 H Cl     OCH.sub.3 CH 203-205 O 0 H H C(O)CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3     OCH.sub.3 N 185-186 O 0 H H C(O)CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 N 170-171 O 0 H H C(O)C.sub.6 H.sub.5 H CH.sub.3 CH.sub.3 CH O     0 H H C(O)C.sub.6 H.sub.5 H CH.sub.3 OCH.sub.3 CH O 0 H H C(O)C.sub.6     H.sub.5 H OCH.sub.3 OCH.sub.3 CH O 0 H H C(O)C.sub.6 H.sub.5 H Cl     OCH.sub.3 CH O 0 H H C(O)C.sub.6 H.sub.5 H CH.sub.3 OCH.sub.3 CH O 0 H H     C(O)C.sub. 6      H.sub.5 H CH.sub.3 OCH.sub.3 CH 88, dec. O 0 H H C(O)CH.sub.2 C.sub.6     H.sub.5 H CH.sub.3 OCH.sub.3 N O 0 H H C(O)CH.sub.2 C.sub.6 H.sub.5 H     OCH.sub.3 OCH.sub.3 N O 0 H H C(O)thienyl H CH.sub.3 OCH.sub.3 CH O 0 H     H C(O)thienyl H OCH.sub.3 OCH.sub.3 CH O 0 H H CO.sub.2 CH.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 CH 210-215 O 0 H H CO.sub.2 CH.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH 171-173 O H H H CO.sub.2 CH.sub.2     CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH 190-195 O 0 H H CO.sub.2     CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH 143-150 O H H H     CO.sub.2 CH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H CO.sub.2     CH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O H H H CO.sub.2      C(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CO.sub.2      C(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CO.sub.2 CH.sub.2     CH.sub.2 OH H CH.sub.3 OCH.sub.3 CH O 0 H H CO.sub.2 CH.sub.2 CH.sub.2     OH H OCH.sub.3 OCH.sub.3 CH O 0 H H C(O)NHCH.sub.3 H CH.sub.3 OCH.sub.3     CH O 0 H H C(O)NHCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H C(O)NHCH.sub.3      H OCH.sub.3 OCH.sub.3 CH O 0 H H C(O)NHCH.sub.2 CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H H C(O)NHCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H H C(O)NH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O H H H C(O)N(CH.sub.3).sub.2 H     CH.sub.3 OCH.sub.3 CH O 0 H H C(O)N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3      CH 202-212 O H H H C(O)NH(cyclohexyl) H CH.sub.3 OCH.sub.3 CH O 0 H H     C(O)NH(cyclohexyl) H OCH.sub.3 OCH.sub.3 CH O 0 H H C(O)NHC.sub.6     H.sub.5 H CH.sub.3 OCH.sub.3 CH O 0 H H C(O)NHC.sub.6 H.sub. 5 H     OCH.sub.3 OCH.sub.3 CH O 0 H H (4,6-dimethylpyrimidin- H CH.sub.3     CH.sub.3 CH 181-183     2-yl)aminocarbonyl O 0 H H (4-methoxy-6-methylpyr     imidin- H CH.sub.3 OCH.sub.3 CH     2-yl)aminocarbonyl O 0 H H (4,6-dimet     hoxypyrimidin- H OCH.sub.3 OCH.sub.3 CH 192-194     2-yl)aminocarbonyl O     0  H H (4-chloro-6-methoxypyrimidin- H Cl OCH.sub.3 CH 206-208     2-yl)aminocarbonyl O 0 H H (4-methoxy-6-methyl-1,3,5- H CH.sub.3     OCH.sub.3 CH     triazin-2-yl)aminocarbonyl O 0 H H (4,6-dimethoxy-1,3,5-      H OCH.sub.3 OCH.sub.3 N     triazin-2-yl)aminocarbonyl O 0 H H CS.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CS.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CS.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH     O 0 H H CS.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CS.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H     CS.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     NH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H NH.sub.2 H OCH.sub.3 OCH.sub.3     CH O 0 H H NHCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H NHCH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H H NHCH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3     CH O 0 H H NHCH.sub.2      CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H NHC.sub.6 H.sub.5 H CH.sub.3     OCH.sub.3 CH O 0 H H NHC.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 CH O 0 H H     4-chlorobenzyl H CH.sub.3 CH.sub.3 CH O 0 H H 4-chlorobenzyl H CH.sub.3     OCH.sub.3 CH O 0 H H 4-chlorobenzyl H OCH.sub.3 OCH.sub.3 CH O 0 H H     4-chlorobenzyl H Cl OCH.sub.3 CH O 0 H H 4-chlorobenzyl H CH.sub.3     OCH.sub.3 N O 0 H H 4-chlorobenzyl H OCH.sub.3 OCH.sub.3 N O 0 H H     4-methylbenzyl H CH.sub.3 CH.sub.3 CH 194-197 O 0 H H 4-methylbenzyl H     CH.sub.3 OCH.sub.3 CH 193-196 O 0 H H 4-methylbenzyl H OCH.sub.3     OCH.sub.3 170-173 O 0 H H 4-methylbenzyl H Cl OCH.sub.3 CH 147-150 O 0 H     H 4-methylbenzyl H CH.sub.3 OCH.sub.3 N 154-157 O 0 H H 4-methylbenzyl H     OCH.sub.3 OCH.sub.3 N 139-143 O 0 H H 4-nitrobenzyl H CH.sub.3 CH.sub.3     CH 223-225 O 0 H H 4-nitrobenzyl H CH.sub.3 OCH.sub.3 CH 218-219 O 0 H H     4-nitrobenzyl H OCH.sub.3 OCH.sub.3 CH 180-183 O 0 H H 4-nitrobenzyl H     Cl OCH.sub.3 CH 200-203 O 0 H H 4-nitrobenzyl H CH.sub.3 OCH.sub.3 N     189-192 O 0 H H 4-nitrobenzyl H OCH.sub.3 OCH.sub.3 N 198-200 O 0 H H     3-trifluoromethylbenzyl H CH.sub.3 CH.sub.3 CH O 0 H H 3-trifluoromethylb     enzyl H CH.sub.3 OCH.sub.3 CH O 0 H H 3-trifluoromethylbenzyl H OCH.sub.3      OCH.sub.3 CH O 0 H H 3-trifluoeomethylbenzyl H Cl OCH.sub.3 CH O 0 H H     3-trifluoromethylbenzyl H CH.sub.3 OCH.sub.3 N O 0 H H 3-trifluoromethylb     enzyl H OCH.sub.3 OCH.sub.3 N O 0 H H 3-methylbenzyl H CH.sub.3 CH.sub.3     CH O 0 H H 3-methylbenzyl H CH.sub.3 OCH.sub.3 CH O 0 H H 3-methylbenzyl     H OCH.sub.3 OCH.sub.3 CH O 0 H H 3-methylbenzyl H Cl OCH.sub.3 CH O 0 H     H 3-methylbenzyl H CH.sub.3 OCH.sub.3 N O 0 H H 3-methylbenzyl H     OCH.sub.3 OCH.sub.3 N O 0 H H 2-methylbenzyl H CH.sub.3 CH.sub.3 CH O 0     H H 2-methylbenzyl H CH.sub.3 OCH.sub.3 CH O 0 H H 2-methylbenzyl H     OCH.sub.3 OCH.sub.3 CH O 0 H H 2-methylbenzyl H Cl OCH.sub.3 CH O 0 H H     2-methylbenzyl H CH.sub.3 OCH.sub.3 N O 0 H H 2-methylbenzyl H OCH.sub.3     OCH.sub.3 N O 0 H H OH H CH.sub.3 OCH.sub.3 CH O 0 H H OH H OCH.sub.3     OCH.sub.3 CH O 0 H H CN H CH.sub.3 CH.sub.3 CH O 0 H H CN H CH.sub.3     OCH.sub.3 CH O 0 H H CN H OCH.sub.3 OCH.sub.3 CH O 0 H H CN H Cl     OCH.sub.3 CH O 0 H H CN H CH.sub.3 OCH.sub.3 N O 0 H H CN H CH.sub.3     OCH.sub.3 N O 0 H H P(O)(OCH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CH O 0 H H     P(O)(OCH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H P(O)(OCH.sub.3).sub     .2 H OCH.sub.3 OCH.sub.3 CH O 0 H H P(O)(OCH.sub.3).sub.2 H Cl OCH.sub.3     CH O 0 H H P(O)(OCH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 N O 0 H H P(O)(OCH.     sub.3).sub.2 H OCH.sub.3 OCH.sub.3 N O 0 H H P(O)(OCH.sub.2      CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H P(S)(OCH.sub.3).sub.2     H OCH.sub.3 OCH.sub.3 CH O 0 H H P(O)(CH.sub.3).sub.2 H OCH.sub.3     OCH.sub.3 CH O 0 H H P(S)(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H     H P(O)(S CH.sub.2 CH.sub.2 CH.sub.2      CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H Si(CH.sub.3).sub.3 H     CH.sub.3 CH.sub.3 CH O 0 H H Si(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3 CH     O 0 H H Si(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H Si(CH.sub.3).     sub.3 H Cl OCH.sub.3 CH O 0 H H Si(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3     N O 0 H H Si(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H Si(CH.sub.3)     .sub.2      C(CH.sub.3).sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H Si(CH.sub.3).sub.2     C(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H Si(CH.sub.3).sub.2     C(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H Si(CH.sub.3).sub.2     C(CH.sub.3).sub.3 H Cl OCH.sub.3 CH O 0 H H Si(CH.sub.3).sub.2      C(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H Si(CH.sub.3).sub.2     C(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H Si(CH.sub.3).sub.2     C.sub.6 H.sub.5 H OCH.sub.3 OCH.sub.3 CH O 0 H H Si(CH.sub.3).sub.2     (CH.sub.2).sub.9 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH S O H H C(O)CH.sub.3     H OCH.sub.3 OCH.sub.3 CH S O H H CO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3     CH S O H H CH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.3 CH S O H H CH.sub.2     CH.sub.2 F H OCH.sub.3 OCH.sub.3 CH S O H H CH.sub.2 C(O)CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH S O H H CF.sub.2 H H OCH.sub.3 OCH.sub.3 CH S O H     H SO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 1 H H OCH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 1 H H C(O)NHCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O     1 H H CS.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 1 H H NH.sub.2 H     OCH.sub.3 OCH.sub.3 CH O 1 H H OH H OCH.sub.3 OCH.sub.3 O 1 H H P(O)(OCH.     sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 1 H H Si(CH.sub.3).sub.2     C(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 CH O 1 H H CH.sub.2 Cl H     OCH.sub.3 OCH.sub.3 CH O 1 H H CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CH O 1     H H CH.sub.2 F H OCH.sub.3 OCH.sub.3 CH O 1 H H CH.sub.2 OCH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 1 H H CH.sub.2 SCN H OCH.sub.3 OCH.sub.3 CH O 1     H H CH.sub.2 NO.sub.2 H OCH.sub.3 OCH.sub.3 CH O 1 H H CH.sub.2 CO.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 1 H H CH.sub.2 CH.sub.2 Cl H     OCH.sub.3 OCH.sub.3 CH O 1 H H CH.sub.2 CH.sub.2      Br H OCH.sub.3 OCH.sub.3 CH O 1 H H CH.sub.2 CH.sub.2 OH H OCH.sub.3     OCH.sub.3 CH O 1 H H CH.sub.2 SO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH     O 1 H H CH.sub.2 SCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 1 H H CH.sub.2     CF.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H C(O)CH.sub.3 H H OCH.sub.3 CH     O 0 H H C(O)CH.sub.3 H CH.sub.2      CH.sub.3 OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH CH.sub.2 CH.sub.2     CH.sub.3 OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH CH.sub.2 CH.sub.2 CH.sub.2     CH.sub.3 OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH OCH.sub.2 CH.sub.3     OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH OCH.sub.2 CH.sub.2 CH.sub.3     OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH OCH.sub.2 CH.sub.2 CH.sub.2     CH.sub.3 OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH OCH(CH.sub.3).sub.2     OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH OCH.sub.2 CF.sub.3 OCH.sub.3 CH O 0     H H C(O)CH.sub.3 CH CH.sub.2 Cl OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH     CH.sub.2 Br OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH CH.sub.2 CH.sub.2 Cl     OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH SCH.sub.3 OCH.sub.3 CH O 0 H H     C(O)CH.sub.3 CH SCH.sub.2 CH.sub.3 OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH     SCH.sub.2 CH.sub.3 Cl O 0 H H C(O)CH.sub.3 CH F OCH.sub.3 CH O 0 H H     C(O)CH.sub.3 CH Cl OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH Br OCH.sub.3 CH     O 0 H H C(O)CH.sub.3 CH OCH.sub.2 CH.sub.2 F OCH.sub.3 CH O 0 H H     C(O)CH.sub.3 CH CH.sub.2 OCH.sub.3 OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH     CH.sub.2 OCH.sub.2 CH.sub.3 OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH     CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 OCH.sub.3 CH O 0 H H     C(O)CH.sub.3 CH OCH.sub.2 OCH.sub.3 OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH     OCH.sub.2 CH.sub.2 OCH.sub.3  OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH     NH.sub.2 OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH NHCH.sub.3 OCH.sub.3 CH O     0 H H C(O)CH.sub.3 CH NHCH.sub.2      CH.sub.3 OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH NHCH(CH.sub.3).sub.2     OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH NHCH.sub.2 CH.sub.2 CH.sub.3     OCH.sub.3 CH O 0 H H C(O)CH.sub.3 CH N(CH.sub.3).sub.2 OCH.sub.3 CH O 0     H H C(O)CH.sub.3 H N(CH.sub.3)CH.sub.2 CH.sub.3 OCH.sub.3 CH O 0 H H     C(O)CH.sub.3 H N(CH.sub.3)C(CH.sub.3).sub.2 OCH.sub.3 CH O 0 H H     C(O)CH.sub.3 H cyclopropyl OCH.sub.3 CH O 0 H H C(O)CH.sub.3 H cyclobutyl      OCH.sub.3 CH O 0 H H C(O)CH.sub.3 H cyclopentyl OCH.sub.3 CH O 0 H H     C(O)CH.sub.3 H OCH.sub.3 H CH O 0 H H C(O)CH.sub.3 H OCH.sub.3 OCH.sub.2     CHCH.sub.2 CH O 0 H H C(O)CH.sub.3 H OCH.sub.3 OCH.sub.2      C(CH.sub.3)CH.sub.2 CH O 0 H H C(O)CH.sub.3 H OCH.sub.3 OCH.sub.2 CCH     CH O 0 H H C(O)CH.sub.3 H OCH.sub.3 OCH.sub.2 CCCH.sub.3 CH O 0 H H     C(O)CH.sub.3 H OCH.sub.3 CH.sub.2 SCH.sub.3 CH O 0 H H C(O)CH.sub.3 H     OCH.sub.3 CH.sub.2      SC(CH.sub.3).sub.3 CH O 0 H H C(O)CH.sub.3 H OCH.sub.3 CH.sub.2     CH.sub.2 CH.sub.2 CH.sub.2 Cl CH O 0 H H C(O)CH.sub.3 H OCH.sub.3     N.sub.3 CH O 0 H H C(O)CH.sub.3 H OCH.sub.3 CN CH O 0 H H C(O)CH.sub.3 H     OCH.sub.3 C(O)CH.sub.3 CH O 0 H H C(O)CH.sub.3 H OCH.sub.3 CHO CH O 0 H     H C(O)CH.sub.3 H OCH.sub.3 C(O)CH(CH.sub.3).sub.2 CH O 0 H H C(O)CH.sub.3      H OCH.sub.3 CH(OCH.sub.3).sub.2 CH O 0 H H C(O)CH.sub.3 H OCH.sub.3     CH(OCH.sub.2 CH.sub.3).sub.2 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2     CH.sub.3 H SCH.sub.3 SCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2     CH.sub.3 H NHCH.sub.3 NHCH.sub.3 CH O 0 H H .sub.--m-CH.sub.3 C(O)CH.sub.     3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-CH.sub.3 C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-CH.sub.2 CH.sub.3 C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-CH.sub.2 CH.sub.2 CH.sub.3 C(O)CH.sub.3 H OCH.sub.     3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3 C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3 C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.2 CH.sub.3 C(O)CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.(CH.sub.3).sub.2 C(O)CH.sub     .3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3 C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-OCH.sub.2 CH.sub.3 C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-OCF.sub.2 H C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.2      F C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3     CF.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.2     CH.sub.2 CH.sub.2      F C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CF.sub.3     C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-CF.sub.3 C(O)CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-CH.sub.2 CH.sub.2 Cl C(O)CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-CH.sub.2 CH.sub.2 CH.sub.2      F C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3     C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-SCH.sub.3 C(O)CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-SCH.sub.2 CH.sub.2 CH.sub.3 C(O)CH.sub.3     H OCH.sub.3 OCH.sub.3 CH O 0 H -o-SCF.sub.3 C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-SCH.sub.2 CH.sub.2 CH.sub.2 Cl C(O)CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-NH.sub.2 C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.-- m-NHCH.sub.3 C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-NHCH.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O     0 H .sub.--m-NH(CH.sub.3).sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O     0 H -o-NH CH.sub.2 CH.sub.2 CH.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3     CH O 0 H -o-NH CH.sub.2 CH.sub.2 CH.sub.3 C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-N(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 C(O)CH.sub.3     H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-F C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -p-F     C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl C(O)CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-Cl C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH     O 0 H  -p-Cl C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Br     C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-Br C(O)CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-I C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-NO.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0     H .sub.--m-CH.sub.3 C(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H -o-CH.sub.     3 C(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H -o-CH.sub.2 CH.sub.3     C(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3 C(O)CH.sub.     3 H CH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3 C(O)CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3 C(O)CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-CF.sub.3 C(O)CH.sub.3 H CH.sub.3 OCH.sub.3     CH O 0 H .sub.--m-SCH.sub.3 C(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H     -o-SCH.sub.3 C(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub     .3).sub.2 C(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F C(O)CH.su     b.3 H CH.sub.3 OCH.sub.3 CH O 0 H -o-F C(O)CH.sub.3 H CH.sub.3 OCH.sub.3     CH O 0 H .sub.--m-Cl C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-Cl     C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Br C(O)CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 C(O)CH.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 C(O)CH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3 C(O)CH.sub.2 CH.sub.3 H     CH.sub. 3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3 C(O)CH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub.2 C(O)CH.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub.2     C(O)CH.sub.2      CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F C(O)CH.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F C(O)CH.sub.2 CH.sub.3     H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl C(O)CH.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl C(O)CH.sub.2      CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Br C(O)CH.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Br C(O)CH.sub.2 CH.sub.3     H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3 C(O)CH.sub.2 CH.sub.3     H CH.sub.3 OCH.sub. 3 CH O 0 H .sub.--m-SCH.sub.3 C(O)CH.sub.2 CH.sub.3     H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 C(O)CH.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 C(O)CH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3 C(O)CH.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3 C(O)CH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-F C(O)CH.sub.2 CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 C(O)CH.sub.2 CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 C(O)CH.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3 C(O)CH.sub.2 CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3 C(O)CH.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub.2 C(O)CH.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub.2 C(O)CH.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F C(O)CH.sub.2 CH.sub.3     H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F C(O)CH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl C(O)CH.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl C(O)CH.sub.2      CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Br C(O)CH.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Br C(O)CH.sub.2 CH.sub.3     H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3 C(O)CH.sub.2 CH.sub.3     H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3 C(O)CH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H  .sub.--m-CH.sub.3 C(O)CH.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 C(O)CH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3 C(O)CH.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3 C(O)CH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-F C(O)CH.sub.2 CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H -o-F C(O)CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O     0 H -o-Cl C(O)CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H -o-Cl     C(O)CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-Br C(O)CH.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H -o-Br C(O)CH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-SCH.sub.3 C(O)CH.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H -o-SCH.sub.3 C(O)CH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3 C(O)CH.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3     C(O)CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3     CH.sub.2 C(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3     CH.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3     CH.sub.2 C(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3     CH.sub.2      C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub.2     CH.sub.2      C(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub.2     CH.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F CH.sub.2     C(O)CH.sub. 3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F CH.sub.2      C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl CH.sub.2     C(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl CH.sub.2      C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Br CH.sub.2     C(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Br CH.sub.2      C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3 CH.sub.2     C(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3 CH.sub.2     C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2     C(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2     C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3 CH.sub.2     C(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3 CH.sub.2     C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-F CH.sub.2 C(O)CH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H -o-F C(O)CH.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-Cl C(O)CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O     0 H -o-Cl C(O)CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-Br     C(O)CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H -o-Br C(O)CH.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-SCH.sub.3 C(O)CH.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H -o-SCH.sub.3 C(O)CH.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3     C(O)CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2     CH.sub.3 C(O)CH.sub.2      CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2     OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2     OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3 CH.sub.2     OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3 CH.sub.2     OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub.2     CH.sub.2      OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub.2     CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F CH.sub.2     OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F CH.sub.2 OCH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl CH.sub.2 OCH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-Cl CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3     CH O 0 H .sub.--m-Br CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-Br CH.sub.2      OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3 CH.sub.2     OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3 CH.sub.2     OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2     OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2     OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3 CH.sub.2 OCH.sub.3     H CH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3 CH.sub.2      OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-F CH.sub.2 OCH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H -o-F CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.     3 CH O 0 H -o-Cl CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H -o-Cl     CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-Br CH.sub.2     OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H -o-Br CH.sub.2 OCH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-SCH.sub.3 CH.sub.2 OCH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H -o-SCH.sub.3 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3     CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.2 OCH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CO.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CO.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H  .sub.--m-OCH.sub.3 CO.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3 CO.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub.2 CO.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub.2     CO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F CO.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F CO.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl CO.sub.2 CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-Cl CO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3     CH O 0 H .sub.--m-Br CO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-Br CO.sub.2      CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub. --m-SCH.sub.3 CO.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3 CO.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CO.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CO.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3 CO.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3 CO.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-F CO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H  o     --F CO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-Cl CO.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H -o-Cl CO.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-Br CO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.     3 CH O 0 H -o-Br CO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H     -o-SCH.sub.3 CO.sub.2      CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H -o-SCH.sub.3 CO.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3 CO.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3     CO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CN H     CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CN H OCH.sub.3 OCH.sub.3     CH O 0 H .sub.--m-OCH.sub.3 CN H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH     .sub.3 CN H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub.2 CN H     CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub. 2 CN H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-F CN H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F      CN H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl CN H CH.sub.3 OCH.sub.3     CH O 0 H .sub.--m-Cl CN H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Br CN H     CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Br CN H OCH.sub.3 OCH.sub.3 CH O 0     H .sub.--m-SCH.sub.3 CN H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3     CN H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CN H CH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CN H OCH.sub.3 OCH.sub.3 CH O 0 H     -o-OCH.sub.3 CN H CH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3 CN H OCH.sub.     3 OCH.sub.3 CH O 0 H -o-F CN H CH.sub.3 OCH.sub.3 CH O 0 H -o-F CN H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-Cl CN H CH.sub.3 OCH.sub.3 CH O 0 H     -o-Cl CN H OCH.sub.3 OCH.sub.3 CH O 0 H -o-Br CN H CH.sub.3 OCH.sub.3 CH     O 0 H -o-Br CN H OCH.sub.3 OCH.sub.3 CH O 0 H -o-SCH.sub.3 CN H CH.sub.3     OCH.sub.3 CH O 0 H -o-SCH.sub.3 CN H OCH.sub.3 OCH.sub.3 CH O 0 H        m     .sub.---OCH.sub.2      CH.sub.3 CN H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3     CN H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2 CN H     CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2 CN H OCH.sub.3     OCH.sub. 3 CH O 0 H .sub.--m-OCH.sub.3 CH.sub.2 CN H CH.sub.3 OCH.sub.3     CH O 0 H .sub.--m-OCH.sub.3 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-N(CH.sub.3).sub.2 CH.sub.2 CN H CH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-N(CH.sub.3).sub.2 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-F CH.sub.2 CN H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F CH.sub.2     CN H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl CH.sub.2 CN H CH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-Cl CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CH O 0     H .sub.--m-Br CH.sub.2 CN H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Br     CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3 CH.sub.2     CN H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3 CH.sub.2 CN H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2 CN H CH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2 CN H OCH.sub.3 OCH.sub.3     CH O 0 H -o-OCH.sub.3 CH.sub.2      CN H CH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3 CH.sub.2 CN H OCH.sub.3     OCH.sub.3 CH O 0 H -o-F CH.sub.2 CN H CH.sub.3 OCH.sub.3 CH O 0 H -o-F     CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CH O 0 H -o-Cl CH.sub.2 CN H CH.sub.3     OCH.sub.3 CH O 0 H -o-Cl CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CH O 0 H     -o-Br CH.sub.2 CN H CH.sub.3 OCH.sub.3 CH O 0 H -o-Br CH.sub.2 CN H     OCH.sub. 3 OCH.sub.3 CH O 0 H -o-SCH.sub.3 CH.sub.2 CN H CH.sub.3     OCH.sub.3 CH O 0 H -o-SCH.sub.3 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CH O 0     H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.2 CN H CH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.2 CN H OCH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-CH.sub.3 CH.sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-CH.sub.3 CH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-OCH.sub.3 CH.sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-OCH.sub.3 CH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-N(CH.sub.3).sub.2 CH.sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.3 CH O     0 H .sub.--m-N(CH.sub.3).sub. 2 CH.sub.2      CHCH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F CH.sub.2      CHCH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F CH.sub.2 CHCH.sub.2     H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl CH.sub.2 CHCH.sub.2 H     CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl CH.sub.2 CHCH.sub.2 H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-Br CH.sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.3     CH O 0 H .sub.--m-Br CH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-SCH.sub.3 CH.sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-SCH.sub.3 CH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-CH.sub.3 CH.sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H      .sub.--m-CH.sub.3 CH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H     -o-OCH.sub.3 CH.sub.2      CHCH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3 CH.sub.2      CHCH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-F CH.sub.2 CHCH.sub.2 H     CH.sub.3 OCH.sub.3 CH O 0 H -o-F CH.sub.2 CHCH.sub.2 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-Cl CH.sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0     H -o-Cl CH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-Br     CH.sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H -o-Br CH.sub.2     CHCH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-SCH.sub.3 CH.sub.2      CHCH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H -o-SCH.sub.3 CH.sub. 2     CHCH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3     CH.sub.2 CHCH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2     CH.sub.3 CH.sub.2      CHCH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2     CCH H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2 CCH H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3 CH.sub.2 CCH H CH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3 CH.sub.2 CCH H OCH.sub.3 OCH.sub.3     CH O 0 H .sub.--m-N(CH.sub.3).sub.2 CH.sub.2 CCH H CH.sub.3 OCH.sub.3 CH     O 0 H .sub.--m-N(CH.sub.3).sub.2 CH.sub.2 CCH H OCH.sub.3 OCH.sub.3 CH O     0 H .sub.--m-F CH.sub.2 CCH H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F     CH.sub.2 CCH H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl CH.sub.2 CCH H     CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl CH.sub.2 CCH H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-Br CH.sub.2 CCH H CH.sub.3 OCH.sub.3 CH O 0     H .sub.--m-Br CH.sub.2      CCH H OCH.sub.3 OCH.sub. 3 CH O 0 H .sub.--m-SCH.sub.3 CH.sub.2 CCH H     CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3 CH.sub.2 CCH H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2 CCH H CH.sub.3 OCH.sub.3     CH O 0 H .sub.--m-CH.sub.3 CH.sub.2 CCH H OCH.sub.3 OCH.sub.3 CH O 0 H     -o-OCH.sub.3 CH.sub.2 CCH H CH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3     CH.sub.2 CCH H OCH.sub.3 OCH.sub.3 CH O 0 H -o-F CH.sub.2 CCH H CH.sub.3     OCH.sub.3 CH O 0 H -o-F CH.sub.2 CCH H OCH.sub.3 OCH.sub.3 CH O 0 H     -o-Cl CH.sub.2 CCH H CH.sub.3 OCH.sub.3 CH O 0 H -o-Cl CH.sub.2 CCH H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-Br CH.sub.2 CCH H CH.sub.3 OCH.sub.3 CH     O 0 H -o-Br CH.sub.2 CCH H OCH.sub.3 OCH.sub.3 CH O 0 H -o-SCH.sub.3     CH.sub.2 CCH H CH.sub.3 OCH.sub.3 CH O 0 H -o-SCH.sub.3 CH.sub.2 CCH H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.-- m-OCH.sub.2 CH.sub.3 CH.sub.2 CCH H     CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.2 CCH H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2 CH.sub.2 F H Cl     OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3 CH.sub.2 CH.sub.2 F H Cl OCH.sub.3     CH O 0 H .sub.--m-OCH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 CH     O 0 H .sub.--m-N(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 F H Cl OCH.sub.3     CH

      W n R R.sub.1 R.sub.2 R.sub.3 X Y Z m.p. (°C.)       O 0 H .sub.--m-N(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3     OCH.sub.3 CH  O 0 H .sub.--m-F CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CH O 0     H .sub.--m-F CH.sub.2 CH.sub.2      F H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl CH.sub.2 CH.sub.2 F H Cl     OCH.sub.3 CH O 0 H .sub.--m-Cl CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3     CH O 0 H .sub.--m-Br CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CH O 0 H     .sub.--m-Br CH.sub.2 CH.sub.2      F H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3 CH.sub.2 CH.sub.2 F     H Cl OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3 CH.sub.2 CH.sub.2 F H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2 CH.sub.2 F H Cl     OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3     OCH.sub.3 CH O 0 H -o-OCH.sub.3 CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CH O     0 H -o-OCH.sub.3 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 CH O 0 H -o-F     CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CH O 0 H -o-F CH.sub.2 CH.sub.2 F H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-Cl CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CH     O 0 H -o-Cl CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 CH O 0 H -o-Br     CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CH O 0 H -o-Br CH.sub.2 CH.sub.2 F H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-SCH.sub.3 CH.sub.2 CH.sub.2 F H Cl     OCH.sub.3 CH O 0 H -o-SCH.sub.3 CH.sub.2 CH.sub.2      F H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.2     CH.sub.2 F H Cl OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.2     CH.sub.2 F H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2     NO.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2     NO.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3 CH.sub.2     NO.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.3 CH.sub.2     NO.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub.2     CH.sub.2      NO.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub.2     CH.sub.2 NO.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F CH.sub.2     NO.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-F CH.sub.2 NO.sub.2 H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl CH.sub.2 NO.sub.2 H CH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-Cl CH.sub.2 NO.sub.2 H OCH.sub.3 OCH.sub.3     CH O 0 H .sub.--m-Br CH.sub.2 NO.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-Br CH.sub.2      NO.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3 CH.sub.2     NO.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3 CH.sub.2     NO.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2     NO.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.-- m-CH.sub.3 CH.sub.2     NO.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3 CH.sub.2 NO.sub.2 H     CH.sub.3 OCH.sub.3 CH O 0 H -o-OCH.sub.3 CH.sub.2 NO.sub.2 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-F CH.sub.2 NO.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H  o     --F CH.sub.2 NO.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-Cl CH.sub.2     NO.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H -o-Cl CH.sub.2 NO.sub.2 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-Br CH.sub.2      NO.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H -o-Br CH.sub.2 NO.sub.2 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-SCH.sub.3 CH.sub.2 NO.sub.2 H CH.sub.3     OCH.sub.3 CH O 0 H -o-SCH.sub.3 CH.sub.2 NO.sub.2 H OCH.sub.3 OCH.sub.3     CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.2 NO.sub.2 H CH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.3 CH.sub.2 NO.sub.2 H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.2 CH.sub.3 H H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH(CH.sub.3).sub.2 H H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub.2 H H OCH.sub.3 OCH.sub.3 CH     O 0 H .sub.--m-OCH.sub.2 CH.sub.2      CH.sub.3 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH(CH.sub.3).     sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.2     CH.sub.3 CH.sub.2      CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH(CH.sub.3).sub.2     CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub     .2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2     CH.sub.2 CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O     0 H .sub.--m-OCH(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub.2 CH.sub.2 CH.sub.2 CH.sub.3     H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.2 CH.sub.3 CH     CH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH(CH.sub.3).     sub.2 CH CH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.     sub.3).sub.2 CH CH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H        m     .sub.---OCH.sub.2 CH.sub.2 CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3     H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-OCH(CH.sub.3).sub.2 CH.sub.2     CH.sub.2 CH.sub.2      CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3).sub.2     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-NHCH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-OCH.sub.2 CH.sub.2 F CH.sub.2 CH.sub.2     CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.2     CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O     0 H H CH.sub.2 CCH H CH.sub.3 CH.sub.3 CH 206-209 O 0 H H CH.sub.2 CCH H     Cl OCH.sub.3 CH 198-200 O 0 H H CH.sub.2 CCH H CH.sub. 3 OCH.sub.3 N     188-190 O 0 H H CH.sub.2 CCH H OCH.sub.3 OCH.sub.3 N 190-192 O 0 H H     CH.sub.2 CH.sub.2 CH.sub.2 OSO.sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0     H H CH.sub.2 CH.sub.2 CH.sub.2 OSO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3     CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 OSO.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 OSO.sub.2 CH.sub.3 H Cl     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 OSO.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 OSO.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CHCH(CH.sub.3).sub.2 H     CH.sub.3 CH.sub.3 CH 204-204.5(d) O 0 H H CH.sub.2 CHCH(CH.sub.3).sub.2     H CH.sub.3 OCH.sub.3 CH 205-208(d) O 0 H H CH.sub.2 CHCH(CH.sub.3).sub.2     H OCH.sub.3 OCH.sub.3 CH 224-226(d) O 0 H H CH.sub.2      CHCH(CH.sub.3).sub.2 H Cl OCH.sub.3 CH 214-215(d) O 0 H H CH.sub.2     CHCH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 N 183-185(d) O 0 H H CH.sub.2     CHCH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 N 170-173(d) O 0 H H C(O)CH.su     b.3 H OCH.sub.2 CH.sub.3 NHCH.sub.3 N O 0 H H C(O)CH.sub.2 CH.sub.3 H     OCH.sub.2 CH.sub.3 NHCH.sub.3 N O 0 H H C(O)CH.sub.2 CH.sub.2 CH.sub.3 H     OCH.sub.2      CH.sub.3 NHCH.sub.3 N O 0 H H C(O)C(CH.sub.3).sub.3 H OCH.sub.2     CH.sub.3 NHCH.sub.3 N O 0 H H CO.sub.2 CH.sub.3 H OCH.sub.2 CH.sub.3     NHCH.sub.3 N O 0 H H CO.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.2 CH.sub.3     NHCH.sub.3 N O 0 H H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.2     CH.sub.3 NHCH.sub.3 N O 0 H H CO.sub.2 CH(CH.sub.3).sub.2 H OCH.sub.2     CH.sub.3 NHCH.sub.3 N O 0 H H CO.sub.2 C(CH.sub.3).sub.3 H OCH.sub.2     CH.sub.3 NHCH.sub.3 N O 0 H H CH.sub.2 C(O)CH.sub.3 H OCH.sub.2 CH.sub.3     NHCH.sub.3 N O 0 H H CH.sub.2 CHCH.sub.2 H OCH.sub.2 CH.sub.3 NHCH.sub.3     N O 0 H H CH.sub.2 CCH H OCH.sub.2 CH.sub.3 NHCH.sub.3 N O 0 H H     CH.sub.2 CH.sub.2 F H OCH.sub.2 CH.sub.3 NHCH.sub.3 N O 0 H H CH.sub.2     CH.sub.2 Cl H OCH.sub.2 CH.sub.3 NHCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2     Br N OCH.sub.2 CH.sub.3 NHCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2     F H OCH.sub.2 CH.sub.3 NHCH.sub.3 N O 0 H H CH.sub.2      CF.sub.3 H OCH.sub.2 CH.sub.3 NHCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2     CF.sub.3 H OCH.sub.2 CH.sub.3 NHCH.sub.3 N O 0 H H CH.sub.2 CHF.sub.2 H     OCH.sub.2 CH.sub.3 NHCH.sub.3 N O 0 H H CH.sub. 2 CN H OCH.sub.2     CH.sub.3 NHCH.sub.3 N O 0 H H CH.sub.2 OCH.sub.3 H OCH.sub.2 CH.sub.3     NHCH.sub.3 N O 0 H H CH.sub.2 Cl H OCH.sub.2 CH.sub.3 NHCH.sub.3 N O 0 H     H C(O)CH.sub.3 H OCH.sub.3 H CH O 0 H H C(O)CH.sub.2      CH.sub.3 H OCH.sub.3 H CH O 0 H H C(O)CH.sub.2 CH.sub.2 CH.sub.3 H     OCH.sub.3 H CH O 0 H H C(O)C(CH.sub.3).sub.3 H OCH.sub.3 H CH O 0 H H     CO.sub.2 CH.sub.3 H OCH.sub.3 H CH O 0 H H CO.sub.2 CH.sub.2 CH.sub.3 H     OCH.sub.3 H CH O 0 H H CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 H     CH O 0 H H CO.sub.2 CH(CH.sub.3).sub.2 H OCH.sub.3 H CH O 0 H H CO.sub.2     C(CH.sub.3).sub.3 H OCH.sub.3 H CH O 0 H H CH.sub.2 C(O)CH.sub.3 H     OCH.sub.3 H CH O 0 H H CH.sub.2 C(O)CH.sub.2 CH.sub.3 H OCH.sub.3 H CH O     0 H H CH.sub.2 CHCH.sub.2 H OCH.sub.3 H CH O 0 H H CH.sub.2 CCH H     OCH.sub.3 H CH O 0 H H CH.sub.2 CH.sub.2 F H OCH.sub.3 H CH O 0 H H     CH.sub.2 CH.sub.2 Cl H OCH.sub.3 H CH O 0 H H CH.sub.2 CH.sub.2 Br H     OCH.sub.3 H CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 H CH O 0     H H CH.sub.2 CF.sub.3 H OCH.sub.3 H CH O 0 H H CH.sub.2 CH.sub.2     CF.sub.3 H OCH.sub.3 H CH O 0 H H CH.sub.2 CHF.sub.2 H OCH.sub.3 H CH O     0 H H CH.sub.2 CN H OCH.sub.3 H CH O 0 H H CH.sub.2      OCH.sub.3 H OCH.sub.3 H CH O 0 H H CH.sub.2 Cl H OCH.sub.3 H CH O 0 H H     C(O)CH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F N O 0 H H C(O)CH.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F N O 0 H H C(O)CH.sub.2     CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2      F N O 0 H H C(O)C(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F N O     0 H H CO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F N O 0 H H     CO.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F N O 0 H H     CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F N O     0 H H CO.sub.2 CH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.2 CH.sub.2 F N O 0     H H CO.sub.2 C(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F N O 0 H     H CH.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F N O 0 H H     CH.sub.2 C(O)CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CH.sub.2 F N O 0 H     H CH.sub.2 CHCH.sub.2 H OCH.sub.3 OCH.sub.2 CH.sub.2 F N O 0 H H     CH.sub.2 C CH H OCH.sub.3 OCH.sub.2 CH.sub.2 F N O 0 H H CH.sub.2 CN H     OCH.sub.3 OCH.sub.2 CH.sub.2 F N O 0 H H CH.sub.2 OCH.sub.3 H OCH.sub.3     OCH.sub.2 CH.sub.2 F N O 0 H H C(O)CH.sub.3 H OCH.sub.3 OCH.sub.2     CF.sub.3 N O 0 H H C(O)CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3     N O 0 H H C(O)CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3     N O 0 H H C(O)C(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 N O 0 H H     CO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 N O 0 H H CO.sub.2     CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 N O 0 H H CO.sub.2     CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 N O 0 H H     CO.sub.2 CH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.2 CF.sub.3 N O 0 H H     CO.sub.2 C(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 N O 0 H H     CH.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 N O 0 H H CH.sub.2     C(O)CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 N O 0 H H CH.sub.2     CHCH.sub.2 H OCH.sub.3 OCH.sub.2 CF.sub.3 N O 0 H H CH.sub.2 CCH H     OCH.sub.3 OCH.sub.2 CF.sub.3 N O 0 H H CH.sub.2 CH.sub.2 F H OCH.sub.3     OCH.sub.2 CF.sub.3 N O 0 H H CH.sub.2 CH.sub.2 Cl H OCH.sub.3 OCH.sub.2     CF.sub.3 N O 0 H H CH.sub.2 CH.sub.2 Br H OCH.sub.3 OCH.sub.2 CF.sub.3 N     O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.2 CF.sub.3 N O     0 H H CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 N O 0 H H     CH.sub.2 CH.sub.2 CF.sub.3 H OCH.sub.3 OCH.sub.2 CF.sub.3 N O 0 H H     CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.2 CF.sub.3 N O 0 H H CH.sub.2 CN     H OCH.sub.3 OCH.sub.2 CF.sub.3 N O 0 H H CH.sub.2 OCH.sub.3 H OCH.sub.3     OCH.sub.2 CF.sub.3 N O 0 H H CH.sub.2 Cl H OCH.sub.3 OCH.sub.2 CF.sub.3     N O 0 H .sub.--m-(CH.sub.2).sub.5 CH.sub.3 C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-(CH.sub.2).sub.3      CH(CH.sub.3).sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-     (CH.sub.2).sub.5 CF.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-O(CH.sub.2).sub.5 CH.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3     CH O 0 H .sub.--m-S(CH.sub.2).sub.5 CH.sub.3 C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-S(O)(CH.sub.2).sub.5 CH.sub.3 C(O)CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-SO.sub.2 (CH.sub.2).sub.5 CH.sub.3     C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H  .sub.--m-CN C(O)CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-O(CH.sub.2).sub.5 CF.sub.3     C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-S(CH.sub.2).sub.5     CF.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-NH(CH.sub.2     ).sub.5      CH.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-N(CH.sub.3     )(CH.sub.2).sub.5 CH.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H     -o-SO.sub.2 NH.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H     -o-SO.sub.2 NH(CH.sub.2).sub.3 CH.sub.3 C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-SO.sub.2      N(CH.sub.3).sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-SO.sub.     2 N(CH.sub.3)OCH.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H     -o-SO.sub.2 N(CH.sub.3)OCH.sub.2 CH.sub.3 C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-SO.sub.2 N(CH.sub.3)CH.sub.2 CN C(O)CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-SO.sub.2 NH(CH.sub.2).sub.3      CN C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-SO.sub.2 NHCH.sub.2   C     CHH.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-azetidinyl-     C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH    sulfonyl O 0 H -o-pyrrolidinyl-     C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH    sulfonyl O 0 H -o-piperidinyl-     C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH    sulfonyl O 0 H -o-morpholino-     C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH    sulfonyl O 0 H .sub.--m-CH.sub.2      OCH.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-CH.sub.2     OCH.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H  .sub.--m-(CH.sub.2     ).sub.3      OCH.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-CH.sub.2     O(CH.sub.2).sub.2 CH.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H     -o-CH.sub.2 SCH.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H     -o-CH.sub.2 S(CH.sub.2).sub.2      CH.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-CH.sub.2 S(O)Pr     C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-CH.sub.2 SO.sub.2 Pr     C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.2 SO.sub.2     N(CH.sub.3).sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH     .sub.2 SO.sub.2 NHPr C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H     -o-CH.sub.2 N(CH.sub.3).sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0     H -o-CH.sub.2      NHPr C(O)CH.sub.3 H OCH.sub. 3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.2     CH.sub.2 N(CH.sub.3).sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-CH.sub.2 NO.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H     -o-(CH.sub.2).sub.3 NO.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H     .sub.--m-CH.sub.2 CN C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H     -o-(CH.sub.2).sub.3 CN C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H     -o-CH.sub.2 CO.sub.2 CH.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0     H -o-(CH.sub.2).sub.2 CO.sub.2 H C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O     0 H .sub.--m-CH.sub.2 CO.sub.2 Pr C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH     O 0 H -o-CH.sub.2 O(CH.sub.2).sub.2 F C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3     CH O 0 H - o-CH.sub.2 O(CH.sub.2).sub.2      CF.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CH.sub.2     OCH.sub.2      CF.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-CH.sub.2     O(CH.sub.2).sub.3 Cl C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H     -o-(CH.sub.2).sub.2 S(CH.sub.2).sub.2 Cl C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-Si(CH.sub.3).sub.3 C(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-Si(CH.sub.3).sub.2 C(CH.sub.3).sub.3 C(O)CH.sub.3     H OCH.sub.3 OCH.sub.3 CH O 0 H -o-Si(CH.sub.3).sub.2 Ph C(O)CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-CO.sub.2 CH.sub.3 C(O)CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-CO.sub.2 (CH.sub.2).sub.2 CH.sub.3     C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-CO.sub.2 CH.sub.2     CHCH.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-CO.sub.2     (CH.sub.2).sub.2 CHCH.sub.2 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H  o     --CO.sub.2 CH.sub.2 CCCH.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0     H -o-CO.sub.2 CH.sub.2 CF.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O     0 H -o-CO.sub.2 (CH.sub.2).sub.4 Cl C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3     CH O 0 H -o-CO.sub.2 CH.sub.2 CN C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O     0 H -o-CO.sub.2 (CH.sub.2).sub.3 CN C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3     CH O 0 H -o-CO.sub.2 -cyclopentyl C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH     O 0 H -o-CO.sub.2 -cyclopentyl C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0     H -o-CO.sub.2 -cyclopropyl- C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH     methyl O 0 H -o-CO.sub.2 -cyclohexyl- C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3     CH    methyl O 0 H -o-CO.sub.2 (CH.sub.2).sub.2 OCH.sub.3 C(O)CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-CO.sub.2 (CH.sub.2).sub.2 OCH.sub.2     CH.sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CN     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CN CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-CN CH.sub.3 H Cl OCH.sub.3 CH O 0 H -o-CN     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H -o-CN CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-CN CH.sub.3 H Cl OCH.sub.3 CH O 0 H -o-CH.sub.2     OCH.sub.3 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H  -o-CH.sub.2 OCH.sub.3     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-CH.sub.2 OCH.sub.3 CH.sub.3 H     Cl OCH.sub.3 CH O 0 H -o-Si(CH.sub.3).sub.3 CH.sub.3 H CH.sub.3 OCH.sub.3      CH O 0 H -o-Si(CH.sub.3).sub.3 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H  o     --Si(CH.sub.3).sub.3 CH.sub.3 H Cl OCH.sub.3 CH O 0 H -o-CH.sub.2     SCH.sub.3 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H -o-CH.sub.2 SCH.sub.3     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-CH.sub.2 SCH.sub.3 CH.sub.3 H     Cl OCH.sub.3 CH O 0 H -o-CH.sub.2 CN CH.sub.3 H CH.sub.3 OCH.sub.3 CH O     0 H -o-CH.sub.2 CN CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-CH.sub.2     CN CH.sub.3 H Cl OCH.sub.3 CH O 0 H .sub.--m-CN CH.sub.2 CH.sub.2     CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CN CH.sub.2     CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-CN     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H Cl OCH.sub.3 CH O 0 H -o-CN     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H -o-CN     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-CN     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H Cl OCH.sub.3 CH O 0 H -o-CH.sub.2     OCH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O     0 H -o-CH.sub.2 OCH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2      CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H -o-CH.sub.2 OCH.sub.3 CH.sub.2     CH.sub.2 CH.sub.2 CH.sub.3 H Cl OCH.sub.3 CH O 0 H -o-Si(CH.sub.3).sub.3     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H     -o-Si(CH.sub.3).sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H -o-Si(CH.sub.3).sub.3 CH.sub.2 CH.sub.2 CH.sub.2     CH.sub.3 H Cl OCH.sub.3 CH O 0 H -o-CH.sub.2 SCH.sub.3 CH.sub.2 CH.sub.2     CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H -o-CH.sub.2 SCH.sub.3     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H     -o-CH.sub.2 SCH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H Cl OCH.sub.3     CH O 0 H -o-CH.sub.2 CN CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H -o-CH.sub.2 CN CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 CH O 0 H -o-CH.sub.2 CN CH.sub.2 CH.sub.2 CH.sub.2     CH.sub.3 H Cl OCH.sub.3 CH O 0 H H (CO).sub.2 OCH.sub.3 H CH.sub.3     CH.sub.3 CH O 0 H H (CO).sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H     (CO).sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H (CO).sub.2     OCH.sub.3 H Cl OCH.sub.3 CH O 0 H H (CO).sub.2 OCH.sub.3 H Br OCH.sub.3     CH O 0 H H (CO).sub.2      OCH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H (CO).sub.2 OCH.sub.3 H     OCH.sub.3 OCH.sub.3 N O 0 H H (CO).sub.2 OCH.sub.2 CH.sub.3 H CH.sub.3     CH.sub.3 CH O 0 H H (CO).sub.2 OCH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3     CH O 0 H H (CO).sub.2 OCH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H     H (CO).sub.2 OCH.sub.2 CH.sub.3 H Cl OCH.sub.3 CH O 0 H H (CO).sub.2     OCH.sub.2 CH.sub.3 H Br OCH.sub.3 CH O 0 H H (CO).sub.2 OCH.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H (CO).sub.2 OCH.sub.2 CH.sub.3 H     OCH.sub.3 OCH.sub.3 N O 0 H H (CO).sub.2 OPh H CH.sub.3 OCH.sub.3 CH O 0     H H (CO).sub.2 OPh H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     SeCH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 SeCH.sub.3 H     CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 SeCH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 SeCH.sub.3 H Cl OCH.sub.3 CH O 0     H H CH.sub.2 CH.sub.2 SeCH.sub.3 H Br OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 SeCH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2     SeCH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 SeCH.sub.2     CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 SeCH.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 SeCH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 SeCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H     H CH.sub.2 CH.sub.2 SePh H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 SePh H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 SePh H     OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 SePh H Cl OCH.sub.3 CH     O 0 H H CH.sub.2 CH.sub.2 SePh H Br OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 SePh H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 SePh H     OCH.sub.3 OCH.sub.3 N O 0 H H (CO).sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3     CH O 0 H H (CO).sub.2      CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H (CO).sub.2 CH.sub.2 CH.sub.3     H CH.sub.3 OCH.sub.3 CH O 0 H H (CO).sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H (CO).sub.2 Ph H CH.sub.3 OCH.sub.3 CH O 0 H H     (CO).sub.2 Ph H OCH.sub.3 OCH.sub.3 CH O 0 H H 2-thienoyl H CH.sub.3     CH.sub.3 CH O 0 H H 2-thienoyl H CH.sub.3 OCH.sub.3 CH O 0 H H 2-thienoyl      H OCH.sub.3 OCH.sub.3 CH O 0 H H 2-thienoyl H Cl OCH.sub.3 CH O 0 H H     2-thienoyl H Br OCH.sub.3 CH O 0 H H 2-thienoyl H CH.sub.3 OCH.sub.3 N O     0 H H 2-thienoyl H OCH.sub.3 OCH.sub.3 N O 0 H H 3-thienoyl H CH.sub.3     CH.sub.3 CH O 0 H H 3-thienoyl H CH.sub.3 OCH.sub.3 CH O 0 H H 3-thienoyl      H OCH.sub.3 OCH.sub.3 CH O 0 H H 3-thienoyl H Cl OCH.sub.3 CH O 0 H H     3-thienoyl H Br OCH.sub.3 CH O 0 H H 3-thienoyl H CH.sub.3 OCH.sub.3 N O     0 H H 3-thienoyl H OCH.sub.3 OCH.sub.3 N O 0 H H 2-furoyl H CH.sub.3     CH.sub.3 CH O 0 H H 2-furoyl H CH.sub. OCH.sub.3 CH O 0 H H 2-furoyl H     OCH.sub.3 OCH.sub.3 CH O 0 H H 2-furoyl H Cl OCH.sub.3 CH O 0 H H     2-furoyl H Br OCH.sub.3 CH O 0 H H 2-furoyl H CH.sub.3 OCH.sub.3 N O 0 H     H 2-furoyl H OCH.sub.3 OCH.sub.3 N O 0 H H 3-furoyl H CH.sub.3 CH.sub.3     CH O 0 H H 3-furoyl H CH.sub.3 OCH.sub.3 CH O 0 H H 3-furoyl H OCH.sub.3     OCH.sub.3 CH O 0 H H 3-furoyl H Cl OCH.sub.3 CH O 0 H H 3-furoyl H Br     OCH.sub.3 CH O 0 H H 3-furoyl H CH.sub.3 OCH.sub.3 N O 0 H H 3-furoyl H     OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 -pyri- H OCH.sub.3     OCH.sub.3 CH     dinium bromide O 0 H H C(O)C(CH.sub.3).sub.3 H CH.sub.3     CH.sub.3 CH 176-178 O 0 H H C(O)C(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3     CH 201-202 O 0 H H C(O)C(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 CH     203-204 O 0 H H C(O)C(CH.sub.3).sub.3 H Cl OCH.sub.3 CH 199-200 O 0 H H     C(O)C(CH.sub.3).sub.3 H Br OCH.sub.3 CH O 0 H H C(O)C(CH.sub.3).sub.3 H     CH.sub.3 OCH.sub.3 N O 0 H H C(O)C(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3     N O 0 H H C(O)CH.sub.2 CH(CH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CH O 0 H H     C(O)CH.sub.2      CH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H C(O)CH.sub.2     CH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H C(O)CH.sub.2     CH(CH.sub.3).sub.2 H Cl OCH.sub.3 CH O 0 H H C(O)CH.sub.2      CH(CH.sub.3).sub.2 H Br OCH.sub.3 CH O 0 H H C(O)CH.sub.2      CH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 N O 0 H H C(O)CH.sub.2      CH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 N O 0 H H C(O)CH(CH.sub.3).sub.     2 H CH.sub.3 OCH.sub.3 CH O 0 H H C(O)CH(CH.sub.3).sub.2 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 C(Br)CH.sub.2 H CH.sub.3 CH.sub.3 CH     220-222 O 0 H H CH.sub.2 C(Br)CH.sub.2 H CH.sub.3 OCH.sub.3 CH 213-214 O     0 H H CH.sub.2 C(Br)CH.sub.2 H OCH.sub.3 OCH.sub.3 CH 211-213 O 0 H H     CH.sub.2 C(Br)CH.sub.2 H Cl OCH.sub.3 CH 188-190 O 0 H H CH.sub.2     C(Br)CH.sub.2 H Br OCH.sub.3 CH O 0 H H CH.sub.2 C(Br)CH.sub.2 H     CH.sub.3 OCH.sub.3 N 190-192 O 0 H H CH.sub.2 C(Br)CH.sub.2 H OCH.sub.3     OCH.sub.3 N 184-185 O 0 H H CHCH.sub.2 H CH.sub.3 CH.sub.3 CH O 0 H H     CHCH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H CHCH.sub.2 H OCH.sub.3     OCH.sub.3 CH O 0 H H CHCH.sub.2 H Cl OCH.sub.3 CH O 0 H H CHCH.sub.2 H     Br OCH.sub.3 CH O 0 H H CHCH.sub.2 H CH.sub.3 OCH.sub.3 N O 0 H H     CHCH.sub.2 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 SO.sub.2     CH.sub.3 H CH.sub.3 CH.sub.3 CH 207-208 O 0 H H CH.sub.2 CH.sub.2     SO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH 149-150 O 0 H H CH.sub.2     CH.sub.2 SO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH 204-205 O 0 H H     CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 H Cl OCH.sub.3 CH 212-214 O 0 H H     CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 H Br OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 SO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 N 197-198 O 0 H H     CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N 195-196 O 0     H H CH.sub.2 CHF.sub.2 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CHF.sub.2     H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CHF.sub.2 H OCH.sub.3 OCH.sub.3     CH O 0 H H CH.sub.2 CHF.sub.2 H Cl CH.sub.3 CH O 0 H H CH.sub.2      CHF.sub.2 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CHF.sub.2 H OCH.sub.     3 OCH.sub.3 N O 0 H H CH.sub.2 CHCl.sub.2 H CH.sub.3 CH.sub.3 CH O 0 H H     CH.sub.2 CHCl.sub.2 H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CHCl.sub.2 H     CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CHCl.sub.2 H OCH.sub.3 OCH.sub.3 N     O 0 H H CH.sub.2 OCH.sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H     CH.sub.2 OCH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     OCH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 OCH.sub.2     CH.sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2 OCH.sub.2 CH.sub.3 H     CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 OCH.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 N O 0 H H CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3     CH.sub.3 CH O 0 H H CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 H Cl OCH.sub.3     CH O 0 H H CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 N O     0 H H CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H     H CH.sub.2 OCH(CH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2     OCH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2      OCH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2      OCH(CH.sub.3).sub.2 H Cl OCH.sub.3 CH O 0 H H CH.sub.2      OCH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2      OCH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2      OC(CH.sub.3).sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2      OC(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2      OC(CH.sub.3).sub.3 H OCH.sub. 3 OCH.sub.3 CH O 0 H H CH.sub.2      OC(CH.sub.3).sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2      OC(CH.sub.3).sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2      OC(CH.sub.3).sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2     SPh H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 SPh H CH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 SPh H OCH.sub.3 OCH.sub.3 CH O 0     H H CH.sub.2 CH.sub.2 SPh H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     SPh H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 SPh H OCH.sub.3     OCH.sub.3 N O 0 H H N(CH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CH O 0 H H     N(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H N(CH.sub.3).sub.2 H     OCH.sub.3 OCH.sub.3 CH O 0 H H N(CH.sub.3).sub.2 H Cl OCH.sub.3 CH O 0 H     H N(CH.sub. 3).sub.2 H CH.sub.3 OCH.sub.3 N O 0 H H N(CH.sub.3).sub.2 H     OCH.sub.3 OCH.sub.3 N O 0 H H cyclopropyl H CH.sub.3 CH.sub.3 CH O 0 H H     cyclopropyl H CH.sub.3 OCH.sub.3 CH O 0 H H cyclopropyl H OCH.sub.3     OCH.sub.3 CH O 0 H H cyclopropyl H Cl OCH.sub.3 CH O 0 H H cyclopropyl H     CH.sub.3 OCH.sub.3 N O 0 H H cyclopropyl H OCH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 CH(CH.sub.3)OH H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2      CH(CH.sub.3)OH H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH(CH.sub.3)OH H     CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH(CH.sub.3)OH H OCH.sub.3     OCH.sub.3 N O 0 H H CH.sub.2 CH(CH.sub.3)OC(O)CH.sub.3 H CH.sub.3     CH.sub.3 CH O 0 H H CH.sub.2 CH(CH.sub.3)OC(O)CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH(CH.sub.3)OC(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub. 2 CH(CH.sub.3)OC(O)CH.sub.3 H Cl OCH.sub.3     CH O 0 H H CH.sub.2 CH(CH.sub.3)OC(O)CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0     H H CH.sub.2 CH(CH.sub.3)OC(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 CH(CH.sub.3)OSO.sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H     CH.sub.2 CH(CH.sub.3)OSO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH(CH.sub.3)OSO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH(CH.sub.3)OSO.sub.2 CH.sub.3 H Cl OCH.sub.3 CH O 0 H H     CH.sub.2 CH(CH.sub.3)OSO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 CH(CH.sub.3)OSO.sub.2 CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 CH.sub.2 CH.sub.2 OH H CH.sub.3 CH.sub.3 OH O 0 H H CH.sub.2     CH.sub.2 CH.sub.2 OH H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     CH.sub.2 OH H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 OH     H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 OC(O)CH.sub.3     H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 OC(O)CH.sub.3     H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 OC(O)CH.sub.3     H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2      OC(O)CH.sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2     OC(O)CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2     OC(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2     CH.sub.2 OH H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2     CH.sub.2 OH H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2     CH.sub.2 OH H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2     CH.sub.2 OH H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2     CH.sub.2 OH H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2     CH.sub.2 OH H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2     CH.sub.2 OC(O)CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     CH.sub.2 CH.sub.2 OC(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CH 170-173 O 0 H H     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 OC(O)CH.sub.3 H OCH.sub.3 OCH.sub.3     CH 199-201 O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 OC(O)CH.sub.3 H     Cl OCH.sub.3 CH 196-198 O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2     OC(O)CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2     CH.sub.2 OC(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2     CH.sub.2 CH.sub.2 OSO.sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 OSO.sub.2 CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 OSO.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2     CH.sub.2 OSO.sub.2 CH.sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     CH.sub.2 CH.sub.2 OSO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 OSO.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 N O 0 H H CH.sub.2 CH(CH.sub.2 CH.sub.3)OH H CH.sub.3 CH.sub.3     CH O 0 H H CH.sub.2 CH(CH.sub.2 CH.sub.3)OH H CH.sub.3 OCH.sub.3 CH O 0     H H CH.sub.2 CH(CH.sub.2 CH.sub.3)OH H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH(CH.sub.2 CH.sub.3)OH H Cl OCH.sub.3 CH O 0 H H CH.sub.2     CH(CH.sub.2 CH.sub.3)OH H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2      CH(CH.sub.2 CH.sub.3)OH H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     CH(CH.sub. 2 CH.sub.3)OC(O)CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H     CH.sub.2 CH(CH.sub.2 CH.sub.3)OC(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0     H H CH.sub.2 CH(CH.sub.2 CH.sub.3)OC(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 CH     O 0 H H CH.sub.2 CH(CH.sub.2 CH.sub.3)OC(O)CH.sub.3 H Cl OCH.sub.3 CH O     0 H H CH.sub.2 CH(CH.sub.2 CH.sub.3)OC(O)CH.sub.3 H CH.sub.3 OCH.sub.3 N     O 0 H H CH.sub.2 CH(CH.sub.2      CH.sub.3)OC(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     CH(CH.sub.2 CH.sub.3)OSO.sub.2 CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H H     CH.sub.2 CH(CH.sub.2 CH.sub.3)OSO.sub.2 CH.sub.3 H CH.sub.3 OCH.sub.3 CH     O 0 H H CH.sub.2 CH(CH.sub.2 CH.sub.3)OSO.sub.2 CH.sub.3 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CH(CH.sub.2 CH.sub.3)OSO.sub.2 CH.sub.3 H     Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH(CH.sub.2 CH.sub.3)OSO.sub.2 CH.sub.3     H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH(CH.sub.2 CH.sub.3)OSO.sub.2     CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CCH H     CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 CCH H Cl OCH.sub.3 CH O 0     H H CH.sub.2 CH.sub.2 CCH H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     CH.sub.2 CCH H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CCCH.sub.3 H     CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CCCH.sub.3 H Cl OCH.sub.3 CH O 0 H     H CH.sub.2 CCCH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2      C CCH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH(CH.sub.3)CCH H CH.sub.3     CH.sub.3 CH O 0 H H CH(CH.sub.3)CCH H Cl OCH.sub.3 CH O 0 H H CH(CH.sub.3     )CCH H CH.sub.3 OCH.sub.3 N O 0 H H CH(CH.sub.3)CCH H OCH.sub.3 OCH.sub.3      N O 0 H H 3-epoxybutyl H CH.sub.3 CH.sub.3 CH O 0 H H 3-epoxybutyl H     CH.sub.3 OCH.sub.3 CH O 0 H H 3-epoxybutyl H OCH.sub.3 OCH.sub.3 CH O 0     H H 3-epoxybutyl H Cl OCH.sub.3 CH O 0 H H 3-epoxybutyl H CH.sub.3     OCH.sub.3 N O 0 H H 3-epoxybutyl H OCH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 CH.sub.2 NH.sub.2 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 NH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2     NH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 NH.sub.2 H     Cl OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 NH.sub.2 H CH.sub.3 OCH.sub.3     N O 0 H H CH.sub.2 CH.sub.2 NH.sub.2 H OCH.sub.3 OCH.sub.3 N O 0 H H     CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H Cl OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 N(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CH O 0 H H     CH.sub. 2 CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH O     0 H H CH.sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3     CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H Cl OCH.sub.3     CH O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H CH.sub.3     OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 H     OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 NHC(O)CH.sub.3 H     CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 NHC(O)CH.sub.3 H Cl     OCH.sub.3 CH O 0 H H CH.sub.2 CH.sub.2 NHC(O)CH.sub.3 H CH.sub.3     OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 NHC(O)CH.sub.3 H OCH.sub.3     OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2 NHCH.sub.3 H CH.sub.3 CH.sub.3 CH     O 0 H H CH.sub.2 CH.sub.2 NHCH.sub.3 H Cl OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 NHCH.sub.3 H CH.sub. 3 OCH.sub.3 N O 0 H H CH.sub.2 CH.sub.2     NHCH.sub.3 H OCH.sub.3 OCH.sub.3 O 0 H H CH.sub.2 C(CH.sub.3)NOH H     CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 C(CH.sub.3)NOH H Cl OCH.sub.3 CH O     0 H H CH.sub.2 C(CH.sub.3)NOH H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     C(CH.sub.3)NOH H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2      C(CH.sub.3)NNH.sub.2 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2            N      C(CH.sub.3)NH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2            N      C(CH.sub.3)NH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2      C(CH.sub.3)NNH.sub.2 H Cl OCH.sub.3 CH O 0 H H CH.sub.2      C(CH.sub.3)NNH.sub.2 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2            N      C(CH.sub.3)NH.sub.2 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2            N      C(CH.sub.3)NHPh H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2      C(CH.sub.3)NNHPh H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2      C(CH.sub.3)NNHPh H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2      C(CH.sub.3)NNHPh H Cl OCH.sub.3 CH O 0 H H CH.sub.2 C(CH.sub.3)NNHPh H     CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 C(CH.sub.3)NNHPh H OCH.sub.3     OCH.sub.3 N O 0 H H CH.sub.2 C(CH.sub.3)NNHCH.sub.3 H CH.sub.3 CH.sub.3     CH O 0 H H CH.sub.2 C(CH.sub.3)NNHCH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H     H CH.sub.2 C(CH.sub.3)NNHCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H H     CH.sub.2 C(CH.sub.3)NNHCH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     CH.sub.2 P(O)(OCH.sub.3).sub.2 H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 P(O)(OCH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 P(O)(OCH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 P(O)(OCH.sub.3).sub.2 H CL OCH.sub.3 CH O 0 H H CH.sub.2     CH.sub.2 P(O)(OCH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     CH.sub.2 P(O)(OCH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2     SCN H CH.sub.3 CH.sub.3 CH O 0 H H CH.sub.2 SCN H Cl OCH.sub.3 CH O 0 H     H CH.sub.2 SCN H CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 SCN H OCH.sub.3     OCH.sub.3 N O 0 H H CH.sub.2 CO.sub.2 CH(CH.sub.3).sub.2 H CH.sub.3     CH.sub.3 CH O 0 H H CH.sub.2 CO.sub.2 CH(CH.sub.3).sub.2 H CH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CO.sub.2 CH(CH.sub.3).sub.2 H OCH.sub.3     OCH.sub.3 CH O 0 H H CH.sub.2 CO.sub.2 CH(CH.sub.3).sub.2 H Cl OCH.sub.3     CH O 0 H H CH.sub.2 CO.sub.2 CH(CH.sub.3).sub.2 H CH.sub.3 OCH.sub.3 N O     0 H H CH.sub.2 CO.sub. 2 CH(CH.sub.3).sub.2 H OCH.sub.3 OCH.sub.3 N O 0     H H cyclopentanone-3-yl H CH.sub.3 CH.sub.3 CH O 0 H H cyclopentanone-3-y     l H CH.sub.3 OCH.sub.3 CH O 0 H H cyclopentanone-3-yl H OCH.sub.3     OCH.sub.3 CH O 0 H H cyclopentanone-3-yl H Cl OCH.sub.3 CH O 0 H H     cyclopentanone-3-yl H CH.sub.3 OCH.sub.3 N O 0 H H cyclopentanone-3-yl H     OCH.sub.3 OCH.sub.3 N O 0 H H cyclohexanone-3-yl H CH.sub.3 CH.sub.3 CH     O 0 H H cyclohexanone-3-yl H CH.sub.3 OCH.sub.3 CH O 0 H H cyclohexanone-     3-yl H OCH.sub.3 OCH.sub.3 CH O 0 H H cyclohexanone-3-yl H Cl OCH.sub.3     CH O 0 H H cyclohexanone-3-yl H CH.sub.3 OCH.sub.3 N O 0 H H cyclohexanon     e-3-yl H OCH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CHCHCCC(CH.sub.3).sub.3     H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2 CHCHCHCH.sub.2 H CH.sub.3     CH.sub.3 CH O 0 H H CH.sub.2 CHCHCHCH.sub.2 H CH.sub.3 OCH.sub.3 CH O 0     H H CH.sub.2 CHCHCHCH.sub.2 H OCH.sub.3 OCH.sub.3 CH O 0 H H CH.sub.2     CHCHCHCH.sub.2 H Cl OCH.sub.3 CH O 0 H H CH.sub.2 CHCHCHCH.sub.2 H     CH.sub.3 OCH.sub.3 N O 0 H H CH.sub.2 CHCHCHCH.sub.2 H OCH.sub.3     OCH.sub.3 N O 0 H .sub.--m-Cl CH.sub.2 CH.sub.2 F H CH.sub.3 CH.sub.3 CH     O 0 H .sub.--m-Cl CH.sub.2 CH.sub.2      F H Cl OCH.sub.3 CH O 0 H .sub.--m-Cl CH.sub.2 CH.sub.2 F H CH.sub.3     OCH.sub.3 N O 0 H .sub.--m-Cl CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3     N O 0 H .sub.--m-Cl C(O)CH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H .sub.--m-Cl      C(O)CH.sub.3 H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl C(O)CH.sub.3 H     Cl OCH.sub.3 CH O 0 H .sub.--m-Cl C(O)CH.sub.3 H CH.sub.3 OCH.sub.3 N O     0 H .sub.--m-Cl C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H .sub.--m-Cl     CH.sub.2 CH.sub.2 CH.sub.2 F H CH.sub.3 CH.sub.3 CH O 0 H .sub.--m-Cl     CH.sub.2 CH.sub.2 CH.sub.2 F H CH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl     CH.sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-Cl     CH.sub.2 CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CH O 0 H .sub.--m-Cl     CH.sub.2 CH.sub.2 CH.sub.2 F H CH.sub.3 OCH.sub.3 N O 0 H .sub.--m-Cl     CH.sub.2 CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 N O 0 H .sub.--m-Cl     CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CH O 0 H .sub.--m-Cl CH.sub.2     OCH.sub.3 H Cl OCH.sub.3 CH O 0 H .sub.--m-Cl CH.sub.2 OCH.sub.3 H     CH.sub.3 OCH.sub.3 N O 0 H .sub.--m-Cl CH.sub.2 OCH.sub.3 H OCH.sub.3     OCH.sub.3 N O 0 H .sub.--m-CH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H     CH.sub.3 CH.sub.3 CH 188-193 O 0 H .sub.--m-CH.sub.3 CH.sub.2 CH.sub.2     OCH.sub.3 H Cl OCH.sub.3 CH 199-124 O 0 H .sub.--m-CH.sub.3 CH.sub.2     CH.sub.2      OCH.sub.3 H CH.sub.3 OCH.sub.3 N 164-172 O 0 H .sub.--m-CH.sub.3     CH.sub.2 CH.sub.2 OCH.sub.3 H OCH.sub.3 OCH.sub.3 N 153-158 O 0 H        p     .sub.---CH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 CH.sub.3 CH O 0     H .sub.--p-CH.sub.3 CH.sub.2 CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.3 CH     O 0 H .sub.--p-CH.sub.3 CH.sub.2 CH.sub.2      OCH.sub.3 H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--p-CH.sub.3 CH.sub.2     CH.sub.2 OCH.sub.3 H Cl OCH.sub.3 CH O 0 H .sub.--p-CH.sub.3 CH.sub.2     CH.sub.2 OCH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H .sub.--p-CH.sub.3     CH.sub.2 CH.sub.2      OCH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H .sub.--m-SCH.sub.3 CH.sub.2     CH.sub.2 F H CH.sub.3 CH.sub.3 CH O 0 H .sub.--m-SCH.sub.3 CH.sub.2     CH.sub.2 F H Cl OCH.sub.3 CH O 0 H .sub.--m-SCH.sub.3 CH.sub.2 CH.sub.2     F H CH.sub.3 OCH.sub.3 N O 0 H .sub.--m-SCH.sub.3 CH.sub.2 CH.sub.2 F H     OCH.sub.3 OCH.sub.3 N O 0 H .sub.--m-SO.sub.2 CH.sub.3 CH.sub.2 CH.sub.2     F H CH.sub.3 CH.sub.3 CH O 0 H .sub.--m-SO.sub.2 CH.sub.3 CH.sub.2     CH.sub.2 F H CH.sub.3 OCH.sub.3 CH O 0 H .sub. --m-SO.sub.2 CH.sub.3     CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 CH O 0 H .sub.--m-SO.sub.2     CH.sub.3 CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CH O 0 H .sub.--m-SO.sub.2     CH.sub.3 CH.sub.2 CH.sub.2      F H CH.sub.3 OCH.sub.3 N O 0 H .sub.--m-SO.sub.2 CH.sub.3 CH.sub.2     CH.sub.2 F H OCH.sub.3 OCH.sub.3 N O 0 H .sub.--m-CF.sub.3 C(O)CH.sub.3     H CH.sub.3 CH.sub.3 CH O 0 H .sub.--m-CF.sub.3 C(O)CH.sub.3 H CH.sub.3     OCH.sub.3 CH O 0 H .sub.--m-CF.sub.3 C(O)CH.sub.3 H Cl OCH.sub.3 CH O 0     H .sub.--m-CF.sub.3 C(O)CH.sub.3 H CH.sub.3 OCH.sub.3 N O 0 H .sub.--m-CF     .sub.3 C(O)CH.sub.3 H OCH.sub.3 OCH.sub.3 N O 0 H H CF.sub.2 CF.sub.2 H     H CH.sub.3 CH.sub.3 CH O 0 H H CF.sub.2 CF.sub.2 H H Cl OCH.sub.3 CH O 0     H H CF.sub.2 CF.sub.2 H H CH.sub.3 OCH.sub.3 N O 0 H H CF.sub.2 CF.sub.2     H H OCH.sub.3 OCH.sub.3 N O 0 H H CH(CH.sub.3)CH(CH.sub.3).sub.2 H     CH.sub.3 CH.sub.3 CH 214-216 O 0 H H CH(CH.sub.3)CH(CH.sub.3).sub.2 H     CH.sub.3 OCH.sub.3 CH 230-233 O 0 H H CH(CH.sub.3)CH(CH.sub.3).sub.2 H     OCH.sub.3 OCH.sub.3 CH 228-231 O 0 H H CH(CH.sub.3)CH(CH.sub.3).sub.2 H     Cl OCH.sub.3 CH 224-272 O 0 H H CH(CH.sub.3)CH(CH.sub.3).sub.2 H     CH.sub.3 OCH.sub.3 N 167-170 O 0 H H CH(CH.sub.3)CH(CH.sub.3).sub.2 H     OCH.sub.3 OCH.sub.3 N 130-133 O 0 H H cyclohexyl H CH.sub.3 CH.sub.3 CH     168-171 O 0 H H cyclohexyl H Cl OCH.sub.3 CH 224-227 O 0 H H cyclohexyl     H CH.sub.3 OCH.sub.3 N 139-142 O 0 H H cyclohexyl H OCH.sub.3 OCH.sub.3     N 184-187 O 0 H H cyclopropyl H CH.sub.3 CH.sub. 3 CH O 0 H H cyclopropyl      H Cl OCH.sub.3 CH O 0 H H cyclopropyl H OCH.sub.3 OCH.sub.3 N O 0 H H     2-fluorobenzyl H CH.sub.3 CH.sub.3 CH 180-183 O 0 H H 2-fluorobenzyl H     CH.sub.3 OCH.sub.3 182-185 O 0 H H 2-fluorobenzyl H Cl OCH.sub.3 CH     180-183 O 0 H H 2-fluorobenzyl H CH.sub.3 OCH.sub.3 N 172-174 O 0 H H     2-fluorobenzyl H OCH.sub.3 OCH.sub.3 N 173-175 O 0 H H 2-chlorobenzyl H     CH.sub.3 CH.sub.3 CH 194-197 O 0 H H 2-chlorobenzyl H CH.sub.3 OCH.sub.3     CH 178-180 O 0 H H 2-chlorobenzyl H OCH.sub.3 OCH.sub.3 CH 200-203 O 0 H     H 2-chlorobenzyl H Cl OCH.sub.3 CH 194-197 O 0 H H 2-chlorobenzyl H     CH.sub.3 OCH.sub.3 N 180-182 O 0 H H 2-chlorobenzyl H OCH.sub.3 OCH.sub.3      N 163-166 O 0 H H 2-bromobenzyl H CH.sub.3 CH.sub.3 CH O 0 H H 2-bromobe     nzyl H CH.sub.3 OCH.sub.3 CH O 0 H H 2-bromobenzyl H OCH.sub.3 OCH.sub.3     CH O 0 H H 2-bromobenzyl H Cl OCH.sub.3 CH O 0 H H 2-bromobenzyl H     CH.sub.3 OCH.sub.3 N O 0 H H 2-bromobenzyl H OCH.sub.3 OCH.sub.3 N O 0 H     .sub.--m-Cl CH.sub.2 CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CH O 0 H     .sub.--m-OCH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CH O 0 H     .sub.--m-SCH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CH O 0 H     .sub.--m-CN CH.sub.2 CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CH O 0 H     .sub.--m-F CH.sub.2 CH.sub.2 CH.sub.2      F H Cl OCH.sub.3 CH O 0 H .sub.--m-CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2     F H Cl OCH.sub.3 CH O 0 H -o-Cl CH.sub.2 CH.sub.2 CH.sub.2 F H Cl     OCH.sub.3 CH O 0 H -o-OCH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 F H Cl     OCH.sub.3 CH O 0 H -o-SCH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 F H Cl     OCH.sub.3 CH O 0 H -o-F CH.sub.2 CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CH O     0 H -o-CN CH.sub.2 CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CH 0 1 H H     CH.sub.2 CH.sub.2 CH.sub.2 F H Cl OCH.sub.3 CH 0 1 H H CH.sub.2 CH.sub.2     F H Cl OCH.sub.3 CH 0 1 H H CH.sub.2 CH.sub.2 F H OCH.sub.3 OCH.sub.3 CH     0 1 H H CH.sub.2 CH.sub.2      F H CH.sub.3 OCH.sub.3 CH

                                      TABLE Ib                                    __________________________________________________________________________     ##STR74##                                                                    W R R.sub.1.sup.'                                                                           R.sub.2     R.sub.4.sup.'                                                                          X   Y   Z  m.p. (°C.)               __________________________________________________________________________    O H H         CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                              H        CH.sub.3                                                                          OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                                      H        CH.sub.3                                                                          OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                                      H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                    H        CH.sub.3                                                                          OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                    H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                             H        CH.sub.3                                                                          OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                             H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH.sub.2 OCH.sub.3                                                               H        CH.sub.3                                                                          OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH.sub.2 OCH.sub.3                                                               H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 Cl H        CH.sub.3                                                                          OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH.sub.2 F                                                                       H        CH.sub.3                                                                          CH.sub.3                                                                          CH                                 O H H         CH.sub.2 CH.sub.2 F                                                                       H        CH.sub.3                                                                          OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH.sub.2 F                                                                       H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH.sub.2 F                                                                       H        CH.sub.3                                                                          OCH.sub.3                                                                         N                                  O H H         CH.sub.3    CH.sub.3 CH.sub.3                                                                          CH.sub.3                                                                          CH                                 O H H         CH.sub.3    CH.sub.3 CH.sub.3                                                                          OCH.sub.3                                                                         CH                                 O H H         CH.sub.3    CH.sub.3 OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H H         CH.sub.3    CH.sub.3 CH.sub.3                                                                          OCH.sub.3                                                                         N                                  O H H         CH.sub.3    CH.sub.3 OCH.sub.3                                                                         OCH.sub.3                                                                         N                                  O H H         CH.sub.3    CH.sub.3 Cl  OCH.sub.3                                                                         CH                                 O H H         CH.sub.3    CH.sub.3 Br  OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH.sub.3                                                                         CH.sub.3 CH.sub.3                                                                          OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH.sub.3                                                                         CH.sub.3 OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H H         Ch.sub.2 CH.sub.3                                                                         CH.sub.3 CH.sub.3                                                                          OCH.sub.3                                                                         N                                  O H H         CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3 OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H H         CH.sub.3    CH.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H H         CH.sub.3    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                    OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H o-CH.sub.2 CH.sub.3                                                                     CH.sub.3    H        CH.sub.3                                                                          OCH.sub.3                                                                         CH                                 O H m-CH.sub.2 CH.sub.3                                                                     CH.sub.3    H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H m-CH.sub.2 CH.sub.3                                                                     CH.sub.3    H        CH.sub.3                                                                          OCH.sub.3                                                                         N                                  O H o-OCH.sub.2 CH.sub.3                                                                    CH.sub.3    H        CH.sub.3                                                                          OCH.sub.3                                                                         CH                                 O H m-OCH.sub.2 CH.sub.3                                                                    CH.sub.3    H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H m-OCH.sub.2 CH.sub.3                                                                    CH.sub.3    H        CH.sub.3                                                                          OCH.sub.3                                                                         N                                  O H H         CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3 CH.sub.3                                                                          CH.sub.3                                                                          CH                                 O H H         CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3 CH.sub.3                                                                          OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3 OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3 CH.sub.3                                                                          OCH.sub.3                                                                         N                                  O H H         CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3 OCH.sub.3                                                                         OCH.sub.3                                                                         N                                  O H H         CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3 Cl  OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3 Br  OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3 CH.sub.3                                                                          CH.sub.3                                                                          CH                                 O H H         CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3 CH.sub.3                                                                          OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3 OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3 CH.sub.3                                                                          OCH.sub.3                                                                         N                                  O H H         CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3 OCH.sub.3                                                                         OCH.sub.3                                                                         N                                  O H H         CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3 Cl  OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3 Br  OCH.sub.3                                                                         CH                                 O H H         CH.sub.2 CH.sub.2 OCH.sub.3                                                               H        --  OCH.sub.3                                                                         N                                  O H H         CH.sub.2 CH.sub.2 OCH.sub.3                                                               H        --  OCH.sub.3                                                                         CH                                 O H o-CH.sub.3                                                                              C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H m-CH.sub.3                                                                              C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H o-CH.sub.2 CH.sub.2 CH.sub.3                                                            C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H o-OCH.sub.3                                                                             C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H m-OCH.sub.3                                                                             C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H o-OCH.sub.2 CH.sub.2 CH.sub.3                                                           C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H o-OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                        C(O)CH.sub.3                                                                              H        OCH.sub. 3                                                                        OCH.sub.3                                                                         CH                                 O H o-CH.sub.2 CH.sub.2 Br                                                                  C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H m-CH.sub.2 CF.sub.3                                                                     C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H o-CF.sub.3                                                                              C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H m-CF.sub.3                                                                              C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H o-CH.sub.2 CH.sub.2 CH.sub.2 F                                                          C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H o-SCH.sub.3                                                                             C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H m-SCH.sub.3                                                                             C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H o-SCH.sub.2 CH.sub.2 CH.sub.3                                                           C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H o-SCH.sub.2 CH.sub.2 CH.sub.2 F                                                         C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H o-NH.sub.2                                                                              C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H o-NHCH.sub.3                                                                            C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H m-N(CH.sub.3).sub.2                                                                     C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H m-NH(CH.sub.2).sub.2 CH.sub.3                                                           C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H m-N(CH.sub.2 CH.sub.2 CH.sub.3).sub.2                                                   C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H o-Cl      C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H m-Cl      C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H p-Cl      C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H o-F       C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H m-F       C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H p-F       C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H o-Br      C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H m-Br      C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H o-NO.sub.2                                                                              C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 O H m-NO.sub.2                                                                              C(O)CH.sub.3                                                                              H        OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                 __________________________________________________________________________

                                      TABLE Ic                                    __________________________________________________________________________     ##STR75##                                                                    W R R.sub.1                                                                           R.sub.2     R.sub.4   X      Y      Z  m.p. (°C.)              __________________________________________________________________________    O H H   CH.sub.3    CH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                             CH                                O H H   CH.sub.3    CH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                O H H   CH.sub.3    CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.3    CH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                             N                                 O H H   CH.sub.3    CH.sub.3  CH.sub.3                                                                             OCH.sub. 3                                                                           N                                 O H H   CH.sub.3    CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 O H H   CH.sub.3    CH.sub.3  Cl     OCH.sub.3                                                                            CH                                O H H   CH.sub.3    CH.sub.3  Br     OCH.sub.3                                                                            CH                                O H H   CH.sub.3    CH.sub.3  OCH.sub.3                                                                            CH(OCH.sub.3).sub.2                                                                  CH                                O H H   CH.sub.3    CH.sub.2 CH.sub.3                                                                       CH.sub.3                                                                             OCH.sub.3                                                                            CH                                O H H   CH.sub.3    CH.sub.2 CH.sub.3                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.3    CH.sub.2 CH.sub.3                                                                       CH.sub.3                                                                             OCH.sub.3                                                                            N                                 O H H   CH.sub.3    CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                             OCH.sub.3                                                                            CH                                O H H   CH.sub.3    CH.sub.2 CH.sub.2 CH.sub.3                                                              OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.3    CH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                             OCH.sub.3                                                                            N                                 O H H   CH.sub.3    CH(CH.sub.3).sub.2                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.3    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.3    CH.sub.2 CH(CH.sub.3).sub.2                                                             OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.3    CH(CH.sub.3)CH.sub.2 CH.sub.3                                                           OCH.sub. 3                                                                           OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                             CH                                O H H   CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.3                                                                         CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                            N                                 O H H   CH.sub.2 CH.sub.3                                                                         CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 O H H   CH.sub.2 CH.sub.3                                                                         CH.sub.3  Cl     OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.3                                                                         CH.sub.3  Br     OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                             CH                                O H H   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3  CH.sub. 3                                                                            OCH.sub.3                                                                            N                                 O H H   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 O H H   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3  Cl     OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3  Br     OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                             CH                                O H H   CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                            N                                 O H H   CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            N                                 O H H   CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3  Cl     OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3  Br     OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                    H         CH.sub.3                                                                             OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                    H         OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                              H         CH.sub.3                                                                             OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                              H         OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 OCH.sub.3                                                               H         CH.sub.3                                                                             OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 OCH.sub.3                                                               H         OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                                                      H         CH.sub.3                                                                             OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                                                      H         OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                             H         CH.sub.3                                                                             OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                             H         OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 SCH.sub.3                                                               H         CH.sub.3                                                                             OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 SCH.sub.3                                                               H         OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 CN                                                                      H         CH.sub.3                                                                             OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 CN                                                                      H         OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Cl                                                                      CH.sub.3    CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Cl                                                                      CH.sub.2 CH.sub.3                                                                         CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Cl                                                                      CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Cl                                                                      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Cl                                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Cl                                                                      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                              CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Cl                                                                      CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                    CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Cl                                                                      CH.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Cl                                                                      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                                                      CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Cl                                                                      CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Br                                                                      CH.sub.3    CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Br                                                                      CH.sub.2 CH.sub.3                                                                         CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Br                                                                      CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Br                                                                      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Br                                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Br                                                                      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                              CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Br                                                                      CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                    CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Br                                                                      CH.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Br                                                                      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                                                      CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-Br                                                                      CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-CH.sub.3                                                                CH.sub.3    CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-CH.sub.3                                                                CH.sub.2 CH.sub.3                                                                         CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-CH.sub.3                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-CH.sub.3                                                                CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-CH.sub.3                                                                CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-CH.sub.3                                                                CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                              CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-CH.sub.3                                                                CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                    CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-CH.sub.3                                                                CH.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-CH.sub.3                                                                CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                                                      CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  .sub.--m-CH.sub.3                                                                CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-Cl                                                                            CH.sub.3    CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-Cl                                                                            CH.sub.2 CH.sub.3                                                                         CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-Cl                                                                            CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-Cl                                                                            CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-Cl                                                                            CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-Cl                                                                            CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                              CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-Cl                                                                            CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                    CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-Cl                                                                            CH.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-Cl                                                                            CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                                                      CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-Cl                                                                            CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-CH.sub.3                                                                      CH.sub.3    CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-CH.sub.3                                                                      CH.sub.2 CH.sub.3                                                                         CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-CH.sub.3                                                                      CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-CH.sub.3                                                                      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-CH.sub.3                                                                      CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-CH.sub.3                                                                      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                              CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-CH.sub.3                                                                      CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                    CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-CH.sub.3                                                                      CH.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-CH.sub.3                                                                      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                                                      CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H  -o-CH.sub.3                                                                      CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH(CH.sub.3)CH.sub.2                                                             CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.3    CH.sub.3  cyclopropyl                                                                          OCH.sub.3                                                                            CH                                O H H   CH.sub.3    CH.sub.3  cyclopropyl                                                                          OCH.sub.3                                                                            N                                 O H H   C(O)CH.sub.3                                                                              CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   C(O)CH.sub.2 CH.sub.3                                                                     CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   C(O)CH.sub.2 CH.sub.2 CH.sub.3                                                            CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CO.sub.2 CH.sub.3                                                                         CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 F                                                                       CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                O H H   CH.sub.2 OCH.sub.3                                                                        CH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                __________________________________________________________________________

                                      TABLE Id                                    __________________________________________________________________________     ##STR76##                                                                                 R.sub.1                                                                       or                                   m.p.                        W.sub.2                                                                          W.sub.1                                                                          J  n R R.sup.1.sup.'                                                                   R.sub.3                                                                         R.sub.5   R.sub.6                                                                          R.sub.7  X   Y   Z  (°C.)                __________________________________________________________________________    -- S  J-5                                                                              0 H H H H         -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-5                                                                              0 H H H CH.sub.3  -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-5                                                                              0 H H H CH.sub.2 CH.sub.3                                                                       -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-5                                                                              0 H H H CH.sub. 2 CH.sub.2 CH.sub.3                                                             -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-5                                                                              0 H H H CH(CH.sub.3).sub.2                                                                      -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-5                                                                              0 H H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-5                                                                              0 H H H CH.sub.2 CH(CH.sub.3).sub.2                                                             -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-5                                                                              0 H H H CH(CH.sub.2)CH.sub.2 CH.sub.3                                                           -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-5                                                                              0 H H H C(CH.sub.3).sub.3                                                                       -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-5                                                                              0 H H H CH.sub.3  -- --       CH.sub.3                                                                          CH.sub.3                                                                          CH                             -- S  J-5                                                                              0 H H H CH.sub.3  -- --       CH.sub.3                                                                          OCH.sub.3                                                                         CH                             -- S  J-5                                                                              0 H H H CH.sub.3  -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-5                                                                              0 H H H CH.sub.3  -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         N                              -- S  J-5                                                                              1 H H H CH.sub.3  -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-5                                                                              1 H H H CH.sub.2 CH.sub.3                                                                       -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-5                                                                              1 H H H CH.sub.2 CH.sub.2 CH.sub.3                                                              -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-5                                                                              1 H H H CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                     -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-5                                                                              1 H H H CH.sub.2 CH(CH.sub.3).sub.2                                                             -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             O  S  J-6                                                                              0 H H H --        -- --       CH.sub.3                                                                          CH.sub.3                                                                          CH                             O  S  J-6                                                                              0 H H H --        -- --       CH.sub.3                                                                          OCH.sub.3                                                                         CH                             O  S  J-6                                                                              0 H H H --        -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             O  S  J-6                                                                              0 H H H --        -- --       CH.sub.3                                                                          CH.sub.3                                                                          N                              O  S  J-6                                                                              0 H H H --        -- --       CH.sub. 3                                                                         OCH.sub.3                                                                         N                              O  S  J-6                                                                              0 H H H --        -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         N                              O  S  J-6                                                                              0 H H H --        -- --       Cl  OCH.sub.3                                                                         CH                             O  S  J-6                                                                              0 H H H --        -- --       Br  OCH.sub.3                                                                         CH                             O  S  J-6                                                                              1 H H H --        -- --       CH.sub.3                                                                          CH.sub.3                                                                          CH                             O  S  J-6                                                                              1 H H H --        -- --       CH.sub.3                                                                          OCH.sub.3                                                                         CH                             O  S  J-6                                                                              1 H H H --        -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             O  S  J-6                                                                              1 H H H --        -- --       CH.sub.3                                                                          CH.sub.3                                                                          N                              O  S  J-6                                                                              1 H H H --        -- --       CH.sub.3                                                                          OCH.sub.3                                                                         N                              O  S  J-6                                                                              1 H H H --        -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         N                              O  S  J-6                                                                              1 H H H --        -- --       Cl  OCH.sub.3                                                                         CH                             O  S  J-6                                                                              1 H H H --        -- --       Br  OCH.sub.3                                                                         CH                             -- S  J-7                                                                              0 H H H H         -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-7                                                                              0 H H H CH.sub.3  -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-7                                                                              1 H H H H         -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-7                                                                              1 H H H CH.sub.3  -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-8                                                                              --                                                                              H H --                                                                              H         -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-8                                                                              --                                                                              H H --                                                                              CH.sub.3  -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-9                                                                              --                                                                              H H --                                                                              H         -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             -- S  J-9                                                                              --                                                                              H H --                                                                              CH.sub.3  -- --       OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             O  S  J-10                                                                             --                                                                              H H --                                                                              --        H  CH.sub.3 CH.sub.3                                                                          CH.sub.3                                                                          CH                             O  S  J-10                                                                             --                                                                              H H --                                                                              --        H  CH.sub.3 CH.sub.3                                                                          OCH.sub.3                                                                         CH                             O  S  J-10                                                                             --                                                                              H H --                                                                              --        H  CH.sub.3 OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             O  S  J-10                                                                             --                                                                              H H --                                                                              --        H  CH.sub.3 CH.sub.3                                                                          OCH.sub.3                                                                         N                              O  S  J-10                                                                             --                                                                              H H --                                                                              --        H  CH.sub.3 OCH.sub.3                                                                         OCH.sub.3                                                                         N                              O  S  J-10                                                                             --                                                                              H H --                                                                              --        H  CH.sub.3 Cl  OCH.sub.3                                                                         CH                             O  S  J-10                                                                             --                                                                              H H --                                                                              --        H  CH.sub.3 Br  OCH.sub.3                                                                         CH                             O  S  J-10                                                                             --                                                                              H H --                                                                              --        H  CH.sub.2 CH.sub.3                                                                      CH.sub.3                                                                          OCH.sub.3                                                                         CH                             O  S  J-10                                                                             --                                                                              H H --                                                                              --        H  CH.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             O  S  J-10                                                                             --                                                                              H H --                                                                              --        H  CH.sub.2 CH.sub.2 CH.sub.3                                                             OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             O  S  J-10                                                                             --                                                                              H H --                                                                              --        H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                    OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             O  S  J-10                                                                             --                                                                              H H --                                                                              --        CH.sub.3                                                                         CH.sub.3 OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             S  S  J-10                                                                             --                                                                              H H --                                                                              --        H  CH.sub.3 OCH.sub.3                                                                         OCH.sub.3                                                                         CH                             __________________________________________________________________________

                                      TABLE Ie                                    __________________________________________________________________________     ##STR77##                                                                                                         m.p.                                     J  W.sub.2                                                                          m'                                                                              n R R.sub.1.sup.'                                                                    R.sub.4                                                                           R.sub.5                                                                           R.sub.6                                                                          X   Y   Z  (°C.)                             __________________________________________________________________________    J-11                                                                             O  --                                                                              0 H H  CH.sub.3                                                                          H   H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                          J-11                                                                             O  --                                                                              0 H H  CH.sub.3                                                                          CH.sub.3                                                                          H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                          J-11                                                                             O  --                                                                              1 H H  CH.sub.3                                                                          H   H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                          J-11                                                                             O  --                                                                              1 H H  CH.sub.3                                                                          H   CH.sub.3                                                                         OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                          J-11                                                                             S  --                                                                              0 H H  CH.sub.3                                                                          H   H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                          J-12                                                                             O  1 0 H H  --  H   H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                          J-12                                                                             O  2 0 H H  --  H   H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                          J-12                                                                             S  1 0 H H  --  H   H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                          J-11                                                                             O  --                                                                              0 H H  Butyl                                                                             H   H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                          J-11                                                                             O  --                                                                              0 H H  CH.sub.3                                                                          Butyl                                                                             H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                          __________________________________________________________________________

                                      TABLE IIa                                   __________________________________________________________________________     ##STR78##                                                                          R.sub.1 '                                                                     or                                m.p.                                  J n R R.sub.1                                                                              R.sub.2    R.sub.3                                                                         R.sub.4                                                                          X.sub.1                                                                             Y.sub.1                                                                          m (°C.)                          __________________________________________________________________________    J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- CH.sub.3                                                                            CH.sub.2                                                                         1                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- OCH.sub.3                                                                           CH.sub.2                                                                         1                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- OCH.sub.2 CH.sub.3                                                                  CH.sub.2                                                                         1                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- OCF.sub.2 H                                                                         CH.sub.2                                                                         1                                       J-1                                                                             0 H H      CH.sub. 2 CH.sub.2 OCH.sub.3                                                             H -- CH.sub.3                                                                            O  1                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- OCH.sub.2 CH.sub.3                                                                  O  1                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- OCF.sub.2 H                                                                         O  1                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- CH.sub.3                                                                            O  2                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- OCH.sub.3                                                                           O  2                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- OCH.sub.2 CH.sub.3                                                                  O  2                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                                                     H -- OCF.sub.2 H                                                                         O  2                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                                                     H -- OCH.sub.3                                                                           CH.sub.2                                                                         1                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                                                     H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                                                     H -- OCH.sub.3                                                                           O  2                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             H -- OCH.sub.3                                                                           CH.sub.2                                                                         1                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             H -- OCH.sub.3                                                                           O  2                                       J-1                                                                             0 H H      CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                   H -- OCH.sub.3                                                                           CH.sub.2                                                                         1                                       J-1                                                                             0 H H      CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                   H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             0 H H      CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                   H -- OCH.sub.3                                                                           O  2                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            H -- OCH.sub.3                                                                           CH.sub.2                                                                         1                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            H -- OCH.sub.3                                                                           O  2                                       J-1                                                                             0 H H      CH.sub.2 C(CH.sub.3)CH.sub.2                                                             H -- OCH.sub.3                                                                           CH.sub.2                                                                         1                                       J-1                                                                             0 H H      CH.sub.2 C(CH.sub.3 )CH.sub.2                                                            H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             0 H H      CH.sub.2 C(CH.sub.3)CH.sub.2                                                             H -- OCH.sub.3                                                                           O  2                                       J-1                                                                             0 H  -o-CH.sub.2 CH.sub.3                                                                CH.sub.3   H -- OCH.sub.3                                                                           CH.sub.2                                                                         1                                       J-1                                                                             0 H  -o-CH.sub.2 CH.sub.3                                                                CH.sub.3   H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             0 H  -o-CH.sub.2 CH.sub.3                                                                CH.sub.3   H -- OCH.sub.3                                                                           O  2                                       J-1                                                                             0 H  -o-OCH.sub.2 CH.sub.3                                                               CH.sub.3   H -- OCH.sub.3                                                                           CH.sub.2                                                                         1                                       J-1                                                                             0 H  -o-OCH.sub.2 CH.sub.3                                                               CH.sub.3   H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             0 H  -o-OCH.sub.2 CH.sub.3                                                               CH.sub.3   H -- OCH.sub.3                                                                           O  2                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- OCH.sub.3                                                                           O  2                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                                                     H -- OCH.sub. 3                                                                          O  1                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                                                     H -- OCH.sub.3                                                                           O  2                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             H -- OCH.sub.3                                                                           O  2                                       J-1                                                                             0 H H      CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                   H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             0 H H      CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                   H -- OCH.sub.3                                                                           O  2                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             0 H H      CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            H -- OCH.sub.3                                                                           O  2                                       J-1                                                                             0 H H      CH.sub.2 C(CH.sub.3)CH.sub.2                                                             H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             0 H H      CH.sub.2 C(CH.sub.3)CH.sub.2                                                             H -- OCH.sub.3                                                                           O  2                                       J-4                                                                             --                                                                              H H      H          --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           O  1                                       J-4                                                                             --                                                                              H H      CH.sub.3   --                                                                              CH.sub.3                                                                         OCH.sub. 3                                                                          O  1                                       J-4                                                                             --                                                                              H H      CH.sub.2 CH.sub.3                                                                        --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           O  1                                       J-4                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 CH.sub.3                                                               --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           O  1                                       J-4                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           O  1                                       J-4                                                                             --                                                                              H H      CH.sub.2 CH(CH.sub.3).sub.2                                                              --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           O  1                                       J-2                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           O  1                                       J-2                                                                             --                                                                              H H      CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                   --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           O  1                                       J-2                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           O  1                                       J-2                                                                             --                                                                              H H      CH.sub.2 C(CH.sub.3)CH.sub.2                                                             --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           O  1                                       J-3                                                                             --                                                                              H H      CH.sub.3   --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           O  1                                       J-3                                                                             --                                                                              H H      CH.sub.2 CH.sub.3                                                                        --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           O  1                                       J-3                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 CH.sub.3                                                               --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           O  1                                       J-3                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           O  1                                       J-3                                                                             --                                                                              H H      CH.sub.2 CH(CH.sub.3).sub.2                                                              --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           O  1                                       J-1                                                                             O H  -o-CH.sub.2 CH.sub.3                                                                CH.sub.2 CH.sub.3                                                                        H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             O H  -o-CH.sub.2 CH.sub.3                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                               H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             O H  .sub.--m-CH.sub.2 CH.sub.3                                                          CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             O H  .sub.--m-CH.sub.2 CH.sub.3                                                          CH.sub.2 CH(CH.sub.3).sub.2                                                              H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             O H  .sub.--m-CH.sub.2 CH.sub.3                                                          H          H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             O H  .sub.--m-OCH.sub.2 CH.sub.3                                                         H          H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             O H  .sub.--m-OCH.sub.2 CH.sub.3                                                         CH.sub.3   H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             O H  .sub.--m-OCH.sub.2 CH.sub.3                                                         CH.sub.2 CH.sub.3                                                                        H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             O H  .sub.--m-OCH.sub.2 CH.sub.3                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                               H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             O H  -o-OCH.sub.2 CH.sub.3                                                               CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      H -- OCH.sub.3                                                                           O  1                                       J-1                                                                             O H  -o-OCH.sub.2 CH.sub.3                                                               CH.sub.2 CH(CH.sub.3).sub.2                                                              H -- OCH.sub.3                                                                           O  1                                       __________________________________________________________________________     *  symbols -o and .sub.--m refer to ortho and meta to sulfonylurea bridge     respectively.                                                            

                                      TABLE IIb                                   __________________________________________________________________________     ##STR79##                                                                                 R.sub.1                                                                       or                         m.p.                                  W.sub.2                                                                          W.sub.1                                                                          J  n R R.sub.1 '                                                                        R.sub.3                                                                         R.sub.5                                                                          R.sub.6                                                                          R.sub.7                                                                            X.sub.1                                                                             Y.sub.1                                                                          m (°C.)                          __________________________________________________________________________    -- S  J-5                                                                              0 H H  H H  -- --   OCH.sub.3                                                                           O  1                                       -- S  J-5                                                                              0 H H  H H  -- --   OCH.sub.3                                                                           O  2                                       -- S  J-5                                                                              0 H H  H CH.sub.3                                                                         -- --   OCH.sub.3                                                                           O  1                                       -- S  J-5                                                                              0 H H  H CH.sub.3                                                                         -- --   OCH.sub.3                                                                           O  2                                       -- S  J-5                                                                              1 H H  H CH.sub.3                                                                         -- --   OCH.sub.3                                                                           O  1                                       -- S  J-5                                                                              1 H H  H CH.sub.3                                                                         -- --   OCH.sub.3                                                                           O  2                                       O  S  J-6                                                                              0 H H  H -- -- --   OCH.sub.3                                                                           O  1                                       O  S  J-6                                                                              0 H H  H -- -- --   OCH.sub.3                                                                           O  2                                       O  S  J-6                                                                              1 H H  H -- -- --   OCH.sub.3                                                                           O  1                                       O  S  J-6                                                                              1 H H  H -- -- --   OCH.sub.3                                                                           O  2                                       -- S  J-7                                                                              0 H H  H H  -- --   OCH.sub.3                                                                           O  1                                       -- S  J-7                                                                              0 H H  H H  -- --   OCH.sub.3                                                                           O  2                                       -- S  J-7                                                                              0 H H  H CH.sub.3                                                                         -- --   OCH.sub.3                                                                           O  1                                       -- S  J-7                                                                              0 H H  H CH.sub.3                                                                         -- --   OCH.sub.3                                                                           O  2                                       -- S  J-7                                                                              1 H H  H CH.sub.3                                                                         -- --   OCH.sub.3                                                                           O  1                                       -- S  J-7                                                                              1 H H  H CH.sub.3                                                                         -- --   OCH.sub.3                                                                           O  2                                       -- S  J-8                                                                              --                                                                              H H  --                                                                              CH.sub.3                                                                         -- --   OCH.sub.3                                                                           O  1                                       -- S  J-8                                                                              --                                                                              H H  --                                                                              CH.sub.3                                                                         -- --   OCH.sub.3                                                                           O  2                                       -- S  J-9                                                                              --                                                                              H H  --                                                                              CH.sub.3                                                                         -- --   OCH.sub.3                                                                           O  1                                       -- S  J-9                                                                              --                                                                              H H  --                                                                              CH.sub.3                                                                         -- --   OCH.sub.3                                                                           O  2                                       O  S  J-10                                                                             --                                                                              H H  --                                                                              -- H  CH.sub.3                                                                           OCH.sub.3                                                                           O  1                                       O  S  J-10                                                                             --                                                                              H H  --                                                                              -- H  CH.sub.3                                                                           OCH.sub.3                                                                           O  2                                       O  S  J-10                                                                             --                                                                              H H  --                                                                              -- H  CH.sub.2 CH.sub.3                                                                  OCH.sub.3                                                                           O  1                                       O  S  J-10                                                                             --                                                                              H H  --                                                                              -- H  CH.sub.2 CH.sub.3                                                                  OCH.sub.3                                                                           O  2                                       O  S  J-10                                                                             --                                                                              H H  --                                                                              -- CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                           O  1                                       O  S  J-10                                                                             --                                                                              H H  --                                                                              -- CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                           O  2                                       O  S  J-6                                                                              1 H H  H -- -- --   CH.sub.3                                                                            CH.sub.2                                                                         1                                       O  S  J-6                                                                              1 H H  H -- -- --   CH.sub.3                                                                            O  1                                       O  S  J-6                                                                              1 H H  H -- -- --   CH.sub.3                                                                            O  2                                       O  S  J-6                                                                              1 H H  H -- -- --   OCH.sub.3                                                                           CH.sub.2                                                                         1                                       O  S  J-6                                                                              1 H H  H -- -- --   OCH.sub.2 CH.sub.3                                                                  CH.sub.2                                                                         1                                       O  S  J-6                                                                              1 H H  H -- -- --   OCH.sub.2 CH.sub.3                                                                  O  1                                       O  S  J-6                                                                              1 H H  H -- -- --   OCH.sub.2 CH.sub.3                                                                  O  2                                       O  S  J-6                                                                              1 H H  H -- -- --   OCF.sub.2 H                                                                         CH.sub.2                                                                         1                                       O  S  J-6                                                                              1 H H  H -- -- --   OCF.sub.2 H                                                                         O  1                                       O  S  J-6                                                                              1 H H  H -- -- --   OCF.sub.2 H                                                                         O  2                                       S  S  J-6                                                                              1 H H  H -- -- --   OCH.sub.3                                                                           O  1                                       __________________________________________________________________________

                  TABLE IIc                                                       ______________________________________                                         ##STR80##                                                                                                                          m.p.                    J    W.sub.2                                                                             m'    n R  R.sub.1 '                                                                          R.sub.4                                                                            R.sub.5                                                                           R.sub.6                                                                           X.sub.1                                                                             Y.sub.1                                                                           m   (°C.)            ______________________________________                                        J-11 O     --    0 H  H    CH.sub.3                                                                           H   H   OCH.sub.3                                                                           O   1                           J-11 O     --    1 H  H    CH.sub.3                                                                           H   H   OCH.sub.3                                                                           O   1                           J-11 S     --    0 H  H    CH.sub.3                                                                           H   H   OCH.sub.3                                                                           O   1                           J-11 S     --    1 H  H    CH.sub.3                                                                           H   H   OCH.sub.3                                                                           O   1                           J-12 O     1     0 H  H    --   H   H   OCH.sub.3                                                                           O   1                           J-12 O     2     0 H  H    --   H   H   OCH.sub. 3                                                                          O   1                           J-12 S     1     0 H  H    --   H   H   OCH.sub.3                                                                           O   1                           J-12 S     2     0 H  H    --   H   H   OCH.sub.3                                                                           O   1                           J-12 O     1     1 H  H    --   H   H   OCH.sub.3                                                                           O   1                           J-12 O     2     1 H  H    --   H   H   OCH.sub.3                                                                           O   1                           J-12 S     1     1 H  H    --   H   H   OCH.sub.3                                                                           O   1                           J-12 S     2     1 H  H    --   H   H   OCH.sub.3                                                                           O   1                           ______________________________________                                    

                                      TABLE IIIa                                  __________________________________________________________________________     ##STR81##                                                                          R.sub.1 *                                                                     or                              m.p.                                    J n R R.sub.1 '*                                                                           R.sub.2    R.sub.3                                                                         R.sub.4                                                                          X.sub.1                                                                             Y.sub.3                                                                          (°C.)                            __________________________________________________________________________    J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- CH.sub.3                                                                            CH.sub.3                                   J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- OCH.sub.3                                                                           H                                          J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- OCH.sub.2 CH.sub.3                                                                  CH.sub.3                                   J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- OCF.sub.2 H                                                                         CH.sub. 3                                  J-1                                                                             0 H H      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                                                     H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             0 H H      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             0 H H      CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                   H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             0 H H      CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             0 H H      CH.sub.2 C(CH.sub.3)CH.sub.2                                                             H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             0 H  -o-CH.sub.2 CH.sub.3                                                                CH.sub.3   H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             0 H  -o-CH.sub.2 CH.sub.3                                                                CH.sub.2 CH.sub.3                                                                        H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             0 H  -o-CH.sub.2 CH.sub.3                                                                CH.sub.2 CH.sub.2 CH.sub.3                                                               H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             0 H  .sub.--m-CH.sub.2 CH.sub.3                                                          CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             0 H  .sub.--m-CH.sub.2 CH.sub.3                                                          CH.sub. 2 CH(CH.sub.3).sub.2                                                             H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             0 H  .sub.--m-CH.sub.2 CH.sub.3                                                          H          H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             0 H  -o-OCH.sub.2 CH.sub.3                                                               H          H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             0 H  -o-OCH.sub.2 CH.sub.3                                                               CH.sub.3   H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             0 H  -o-OCH.sub.2 CH.sub.3                                                               CH.sub.2 CH.sub.3                                                                        H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             0 H  .sub.--m-OCH.sub.2 CH.sub.3                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                               H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             0 H  .sub.--m-OCH.sub.2 CH.sub.3                                                         CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             0 H  .sub.--m-OCH.sub.2 CH.sub.3                                                         CH.sub.2 CH(CH.sub.3).sub.2                                                              H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             1 H H      CH.sub.2 CH.sub.3 OCH.sub.3                                                              H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             1 H H      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                                                     H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             1 H H      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             1 H H      CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                   H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             1 H H      CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            H -- OCH.sub.3                                                                           CH.sub.3                                   J-1                                                                             1 H H      CH.sub.2 C(CH.sub.3)CH.sub.2                                                             H -- OCH.sub.3                                                                           CH.sub.3                                   J-2                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              --                                                                              -- OCH.sub.3                                                                           CH.sub.3                                   J-2                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                                                     --                                                                              -- OCH.sub.3                                                                           CH.sub.3                                   J-2                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             --                                                                              -- OCH.sub.3                                                                           CH.sub.3                                   J-2                                                                             --                                                                              H H      CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                   --                                                                              -- OCH.sub.3                                                                           CH.sub.3                                   J-2                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            --                                                                              -- OCH.sub.3                                                                           CH.sub.3                                   J-2                                                                             --                                                                              H H      CH.sub.2 C(CH.sub.3)CH.sub.2                                                             --                                                                              -- OCH.sub.3                                                                           CH.sub.3                                   J-3                                                                             --                                                                              H H      H          --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-3                                                                             --                                                                              H H      CH.sub.3   --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-3                                                                             --                                                                              H H      CH.sub.2 CH.sub.3                                                                        --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-3                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 CH.sub.3                                                               --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-3                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-3                                                                             --                                                                              H H      CH.sub.2 CH(CH.sub.3).sub.2                                                              --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-3                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-3                                                                             --                                                                              H H      CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                   --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-3                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-3                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-4                                                                             --                                                                              H H      H          --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-4                                                                             --                                                                              H H      CH.sub.3   --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-4                                                                             --                                                                              H H      CH.sub.2 CH.sub.3                                                                        --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-4                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 CH.sub.3                                                               --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-4                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-4                                                                             --                                                                              H H      CH.sub.2 CH(CH.sub.3).sub.2                                                              --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-4                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-4                                                                             --                                                                              H H      CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                   --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-4                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   J-4                                                                             --                                                                              H H      CH.sub.2 CH.sub.2 OCH.sub.3                                                              --                                                                              CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.3                                   __________________________________________________________________________     *  symbols -o and .sub.--m refer to ortho and meta to the sulfonylurea        bridge respectively.                                                     

                                      TABLE IIIb                                  __________________________________________________________________________     ##STR82##                                                                                 R.sub.1                                                                       or                      m.p.                                     W.sub.2                                                                          W.sub.1                                                                          J  n R R.sub.1 '                                                                        R.sub.3                                                                         R.sub.5                                                                          R.sub.6                                                                         R.sub.7                                                                            X.sub.1                                                                             Y.sub.3                                                                          (°C.)                             __________________________________________________________________________    -- S  J-5                                                                              0 H H  H CH.sub.3                                                                         --                                                                              --   OCH.sub.3                                                                           CH.sub.3                                    -- S  J-5                                                                              1 H H  H CH.sub.3                                                                         --                                                                              --   OCH.sub.3                                                                           CH.sub.3                                    O  S  J-6                                                                              0 H H  H -- --                                                                              --   OCH.sub.3                                                                           CH.sub.3                                    O  S  J-6                                                                              1 H H  H -- --                                                                              --   OCH.sub. 3                                                                          CH.sub.3                                    -- S  J-7                                                                              0 H H  H CH.sub.3                                                                         --                                                                              --   OCH.sub.3                                                                           CH.sub.3                                    -- S  J-7                                                                              1 H H  H CH.sub.3                                                                         --                                                                              --   OCH.sub.3                                                                           CH.sub.3                                    -- S  J-8                                                                              --                                                                              H H  H CH.sub.3                                                                         --                                                                              --   OCH.sub.3                                                                           CH.sub.3                                    -- S  J-9                                                                              --                                                                              H H  H CH.sub.3                                                                         --                                                                              --   OCH.sub.3                                                                           CH.sub.3                                    O  S  J-10                                                                             --                                                                              H H  H -- H CH.sub.3                                                                           OCH.sub.3                                                                           CH.sub.3                                    O  S  J-10                                                                             --                                                                              H H  H -- H CH.sub.2 CH.sub.3                                                                  OCH.sub.3                                                                           CH.sub.3                                    O  S  J-6                                                                              1 H H  H -- --                                                                              --   OCH.sub.3                                                                           H                                           O  S  J-6                                                                              1 H H  H -- --                                                                              --   CH.sub.3                                                                            H                                           O  S  J-6                                                                              1 H H  H -- --                                                                              --   OCH.sub.2 CH.sub.3                                                                  H                                           O  S  J-6                                                                              1 H H  H -- --                                                                              --   OCF.sub.2 H                                                                         H                                           O  S  J-6                                                                              1 H H  H -- --                                                                              --   CH.sub.3                                                                            CH.sub.3                                    O  S  J-6                                                                              1 H H  H -- --                                                                              --   OCH.sub.2 CH.sub.3                                                                  CH.sub.3                                    O  S  J-6                                                                              1 H H  H -- --                                                                              --   OCF.sub.2 H                                                                         CH.sub.3                                    __________________________________________________________________________

                                      TABLE IIIc                                  __________________________________________________________________________     ##STR83##                                                                                                      m.p.                                        J  W.sub.2                                                                          m' n  R  R.sub.1 '                                                                        R.sub.4                                                                          R.sub.5                                                                          R.sub.6                                                                          X.sub.1                                                                           Y.sub.3                                                                          (°C.)                                __________________________________________________________________________    J-11                                                                             O  -- 0  H  H  CH.sub.3                                                                         H  H  OCH.sub.3                                                                         CH.sub.3                                       J-11                                                                             O  -- 1  H  H  CH.sub.3                                                                         H  H  OCH.sub.3                                                                         CH.sub.3                                       J-11                                                                             S  -- 0  H  H  CH.sub.3                                                                         H  H  OCH.sub.3                                                                         CH.sub.3                                       J-11                                                                             S  -- 1  H  H  CH.sub.3                                                                         H  H  OCH.sub.3                                                                         CH.sub.3                                       J-12                                                                             O  1  0  H  H  -- H  H  OCH.sub.3                                                                         CH.sub.3                                       J-12                                                                             O  2  0  H  H  -- H  H  OCH.sub.3                                                                         CH.sub.3                                       J-12                                                                             O  1  1  H  H  -- H  H  OCH.sub.3                                                                         CH.sub.3                                       J-12                                                                             O  2  1  H  H  -- H  H  OCH.sub.3                                                                         CH.sub.3                                       __________________________________________________________________________

                                      TABLE IVa                                   __________________________________________________________________________     ##STR84##                                                                          R.sub.1 *                                                                     or                               m.p.                                   J n R R.sub.1 '*                                                                          R.sub.2    R.sub.3                                                                         R.sub.4                                                                          X.sub.2                                                                            Y.sub.2                                                                             (°C.)                           __________________________________________________________________________    J-1                                                                             0 H H     CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- CH.sub.3                                                                           OCH.sub.3                                    J-1                                                                             0 H H     CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- CH.sub.2 CH.sub.3                                                                  OCH.sub.3                                    J-1                                                                             0 H H     CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- CH.sub.2 CF.sub.3                                                                  OCH.sub.3                                    J-1                                                                             0 H H     CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- CH.sub.3                                                                           OCH.sub.2 CH.sub.3                           J-1                                                                             0 H H     CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- CH.sub.3                                                                           SCH.sub.3                                    J-1                                                                             0 H H     CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- CH.sub.3                                                                           SCH.sub.2 CH.sub.3                           J-1                                                                             0 H H     CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- CH.sub.3                                                                           CH.sub.3                                     J-1                                                                             0 H H     CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- CH.sub.3                                                                           CH.sub.2 CH.sub.3                            J-1                                                                             0 H H     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             H -- CH.sub.3                                                                           OCH.sub.3                                    J-1                                                                             0 H H     CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                   H -- CH.sub.3                                                                           OCH.sub.3                                    J-1                                                                             0 H H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            H -- CH.sub.3                                                                           OCH.sub.3                                    J-1                                                                             0 H  -o-CH.sub.2 CH.sub.3                                                               H          H -- CH.sub.3                                                                           OCH.sub.3                                    J-1                                                                             0 H  -o-CH.sub.2 CH.sub.3                                                               CH.sub.3   H -- CH.sub.3                                                                           OCH.sub.3                                    J-1                                                                             0 H  -o-CH.sub.2 CH.sub.3                                                               CH.sub.2 CH.sub.3                                                                        H -- CH.sub.3                                                                           OCH.sub.3                                    J-1                                                                             0 H  -o-CH.sub.2 CH.sub.3                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                               H -- CH.sub.3                                                                           OCH.sub.3                                    J-1                                                                             0 H  -o-CH.sub.2 CH.sub.3                                                               CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      H -- CH.sub.3                                                                           OCH.sub.3                                    J-1                                                                             0 H  -o-CH.sub.2 CH.sub.3                                                               CH.sub.2 CH(CH.sub.3).sub.2                                                              H -- CH.sub.3                                                                           OCH.sub.3                                    J-1                                                                             1 H H     CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- CH.sub.3                                                                           OCH.sub.3                                    J-1                                                                             1 H H     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             H -- CH.sub.3                                                                           OCH.sub.3                                    J-1                                                                             1 H H     CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                   H -- CH.sub.3                                                                           OCH.sub.3                                    J-1                                                                             1 H H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            H -- CH.sub.3                                                                           OCH.sub.3                                    J-2                                                                             --                                                                              H H     CH.sub.2 CH.sub.2 OCH.sub.3                                                              --                                                                              -- CH.sub.3                                                                           OCH.sub.3                                    J-2                                                                             --                                                                              H H     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             --                                                                              -- CH.sub.3                                                                           OCH.sub.3                                    J-2                                                                             --                                                                              H H     CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                   --                                                                              -- CH.sub.3                                                                           OCH.sub.3                                    J-2                                                                             --                                                                              H H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            --                                                                              -- CH.sub.3                                                                           OCH.sub.3                                    J-3                                                                             --                                                                              H H     CH.sub.3   --                                                                              CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                    J-3                                                                             --                                                                              H H     CH.sub.2 CH.sub.3                                                                        --                                                                              CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                    J-3                                                                             --                                                                              H H     CH.sub.2 CH.sub.2 CH.sub.3                                                               --                                                                              CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                    J-3                                                                             --                                                                              H H     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      --                                                                              CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                    J-3                                                                             --                                                                              H H     CH.sub.2 CH(CH.sub.3).sub.2                                                              --                                                                              CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                    J-3                                                                             --                                                                              H H     CH.sub.2 CH.sub.2 OCH.sub.3                                                              --                                                                              CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                    J-3                                                                             --                                                                              H H     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             --                                                                              CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                    J-3                                                                             --                                                                              H H     CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                   --                                                                              CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                    J-3                                                                             --                                                                              H H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            --                                                                              CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                    J-4                                                                             --                                                                              H H     CH.sub.3   --                                                                              CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                    J-4                                                                             --                                                                              H H     CH.sub.2 CH.sub.3                                                                        --                                                                              CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                    J-4                                                                             --                                                                              H H     CH.sub.2 CH.sub.2 CH.sub.3                                                               --                                                                              CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                    J-4                                                                             --                                                                              H H     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      --                                                                              CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                    J-4                                                                             --                                                                              H H     CH.sub.2 CH(CH.sub.3).sub.2                                                              --                                                                              CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                    J-4                                                                             --                                                                              H H     CH.sub.2 CH.sub.2 OCH.sub.3                                                              --                                                                              CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                    J-4                                                                             --                                                                              H H     CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             --                                                                              CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                    J-4                                                                             --                                                                              H H     CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3                                                   --                                                                              CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                    J-4                                                                             --                                                                              H H     CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            --                                                                              CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                    __________________________________________________________________________     *-- symbols -o and .sub.--m refer to ortho and meta to sulfonylurea bridg     respectively.                                                            

                                      TABLE IVb                                   __________________________________________________________________________     ##STR85##                                                                                 R.sub.1                                                                       or                        m.p.                                   W.sub.2                                                                          W.sub.1                                                                          J  n R R.sub.1 '                                                                        R.sub.3                                                                         R.sub.5                                                                          R.sub.6                                                                         R.sub.7                                                                            X.sub.2                                                                            Y.sub.2                                                                             (°C.)                           __________________________________________________________________________    -- S  J-5                                                                              0 H H  H CH.sub.3                                                                         --                                                                              --   CH.sub.3                                                                           OCH.sub.3                                    -- S  J-5                                                                              1 H H  H CH.sub.3                                                                         --                                                                              --   CH.sub.3                                                                           OCH.sub.3                                    O  S  J-6                                                                              0 H H  H -- --                                                                              --   CH.sub.3                                                                           OCH.sub.3                                    O  S  J-6                                                                              1 H H  H -- --                                                                              --   CH.sub.3                                                                           OCH.sub. 3                                   -- S  J-7                                                                              0 H H  H CH.sub.3                                                                         --                                                                              --   CH.sub.3                                                                           OCH.sub.3                                    -- S  J-7                                                                              1 H H  H CH.sub.3                                                                         --                                                                              --   CH.sub.3                                                                           OCH.sub.3                                    -- S  J-8                                                                              --                                                                              H H  H CH.sub.3                                                                         --                                                                              --   CH.sub.3                                                                           OCH.sub.3                                    -- S  J-9                                                                              --                                                                              H H  H CH.sub.3                                                                         --                                                                              --   CH.sub.3                                                                           OCH.sub.3                                    O  S  J-10                                                                             --                                                                              H H  H -- H CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                                    O  S  J-10                                                                             --                                                                              H H  H -- H CH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                           OCH.sub.3                                    O  S  J-6                                                                              1 H H  H -- --                                                                              --   CH.sub.3                                                                           OCH.sub.2 CH.sub.3                           O  S  J-6                                                                              1 H H  H -- --                                                                              --   CH.sub.3                                                                           SCH.sub.3                                    O  S  J-6                                                                              1 H H  H -- --                                                                              --   CH.sub.3                                                                           SCH.sub.2 CH.sub.3                           O  S  J-6                                                                              1 H H  H -- --                                                                              --   CH.sub.3                                                                           CH.sub.3                                     O  S  J-6                                                                              1 H H  H -- --                                                                              --   CH.sub.3                                                                           CH.sub.2 CH.sub.3                            O  S  J-6                                                                              1 H H  H -- --                                                                              --   CH.sub.2 CH.sub.3                                                                  OCH.sub.3                                    O  S  J-6                                                                              1 H H  H -- --                                                                              --   CH.sub.2 CF.sub.3                                                                  OCH.sub.3                                    __________________________________________________________________________

                                      TABLE IVc                                   __________________________________________________________________________     ##STR86##                                                                                                      m.p.                                        J  W.sub.2                                                                          m' n  R  R.sub.1 '                                                                        R.sub.4                                                                          R.sub.5                                                                          R.sub.6                                                                          X.sub.2                                                                          Y.sub.2                                                                           (°C.)                                __________________________________________________________________________    J-11                                                                             O  -- 0  H  H  CH.sub.3                                                                         H  H  CH.sub.3                                                                         OCH.sub.3                                       J-11                                                                             O  -- 1  H  H  CH.sub.3                                                                         H  H  CH.sub.3                                                                         OCH.sub.3                                       J-11                                                                             S  -- 0  H  H  CH.sub.3                                                                         H  H  CH.sub.3                                                                         OCH.sub.3                                       J-11                                                                             S  -- 1  H  H  CH.sub.3                                                                         H  H  CH.sub.3                                                                         OCH.sub.3                                       J-12                                                                             O  1  0  H  H  -- H  H  CH.sub.3                                                                         OCH.sub.3                                       J-12                                                                             O  1  1  H  H  -- H  H  CH.sub.3                                                                         OCH.sub.3                                       J-12                                                                             O  2  0  H  H  -- H  H  CH.sub.3                                                                         OCH.sub.3                                       J-12                                                                             O  2  1  H  H  -- H  H  CH.sub.3                                                                         OCH.sub.3                                       __________________________________________________________________________

                                      TABLE Va                                    __________________________________________________________________________     ##STR87##                                                                    J n R R.sub.1 or R'.sub.1                                                                R.sub.2    R.sub.3                                                                         R.sub.4                                                                          X.sub.3                                                                           m.p. (°C.)                              __________________________________________________________________________    J-1                                                                             0 H H    CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- CH.sub.3                                           J-1                                                                             0 H H    CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- OCH.sub.3                                          J-1                                                                             0 H H    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             H -- OCH.sub.3                                          J-1                                                                             0 H H    CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            H -- OCH.sub.3                                          J-1                                                                             1 H H    CH.sub.2 CH.sub.2 OCH.sub.3                                                              H -- OCH.sub.3                                          J-1                                                                             1 H H    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             H -- OCH.sub.3                                          J-1                                                                             1 H H    CH.sub.2 CH.sub. 2 CH.sub.2 Cl                                                           H -- OCH.sub.3                                          J-2                                                                             --                                                                              H H    CH.sub.2 CH.sub.2 OCH.sub.3                                                              --                                                                              -- OCH.sub.3                                          J-2                                                                             --                                                                              H H    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             --                                                                              -- OCH.sub.3                                          J-2                                                                             --                                                                              H H    CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            --                                                                              -- OCH.sub.3                                          J-3                                                                             --                                                                              H H    CH.sub.2 CH.sub.2 OCH.sub.3                                                              --                                                                              CH.sub.3                                                                         OCH.sub.3                                          J-3                                                                             --                                                                              H H    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             --                                                                              CH.sub.3                                                                         OHC.sub.3                                          J-3                                                                             --                                                                              H H    CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            --                                                                              CH.sub.3                                                                         OCH.sub.3                                          J-3                                                                             --                                                                              H H    CH.sub.3   --                                                                              CH.sub.3                                                                         OCH.sub.3                                          J-3                                                                             --                                                                              H H    CH.sub.2 CH.sub.3                                                                        --                                                                              CH.sub.3                                                                         OCH.sub.3                                          J-3                                                                             --                                                                              H H    CH.sub.2 CH.sub.2 CH.sub.3                                                               --                                                                              CH.sub.3                                                                         OCH.sub.3                                          J-3                                                                             --                                                                              H H    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      --                                                                              CH.sub.3                                                                         OCH.sub.3                                          J-3                                                                             --                                                                              H H    CH.sub.2 CH(CH.sub.3).sub.2                                                              --                                                                              CH.sub.3                                                                         OCH.sub.3                                          J-4                                                                             --                                                                              H H    CH.sub.2 CH.sub.2 OCH.sub.3                                                              --                                                                              CH.sub.3                                                                         OCH.sub.3                                          J-4                                                                             --                                                                              H H    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                             --                                                                              CH.sub.3                                                                         OCH.sub.3                                          J-4                                                                             --                                                                              H H    CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            --                                                                              CH.sub.3                                                                         OCH.sub.3                                          J-4                                                                             --                                                                              H H    H          --                                                                              CH.sub.3                                                                         OCH.sub.3                                          J-4                                                                             --                                                                              H H    CH.sub.3   --                                                                              CH.sub.3                                                                         OCH.sub.3                                          J-4                                                                             --                                                                              H H    CH.sub.2 CH.sub.3                                                                        --                                                                              CH.sub.3                                                                         OCH.sub.3                                          J-4                                                                             --                                                                              H H    CH.sub.2 CH.sub.2 CH.sub.3                                                               --                                                                              CH.sub.3                                                                         OCH.sub.3                                          J-4                                                                             --                                                                              H H    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      --                                                                              CH.sub.3                                                                         OCH.sub.3                                          J-4                                                                             --                                                                              H H    CH.sub.2 CH(CH.sub.3).sub.2                                                              --                                                                              CH.sub.3                                                                         OCH.sub.3                                          __________________________________________________________________________

                                      TABLE Vb                                    __________________________________________________________________________     ##STR88##                                                                    W.sub.2                                                                          W.sub.1                                                                          J  n R R.sub.1 or R.sub.1 '                                                               R.sub.3                                                                         R.sub.5                                                                          R.sub.6                                                                         R.sub.7                                                                            X.sub.3                                                                           m.p. (°C.)                           __________________________________________________________________________    -- S  J-5                                                                              0 H H    H CH.sub.3                                                                         --                                                                              --   CH.sub.3                                        -- S  J-5                                                                              0 H H    H CH.sub.3                                                                         --                                                                              --   OCH.sub.3                                       -- S  J-5                                                                              1 H H    H CH.sub.3                                                                         --                                                                              --   CH.sub.3                                        -- S  J-5                                                                              1 H H    H CH.sub.3                                                                         --                                                                              --   OCH.sub.3                                       O  S  J-6                                                                              0 H H    H -- --                                                                              --   CH.sub.3                                        O  S  J-6                                                                              0 H H    H -- --                                                                              --   OCH.sub. 3                                      O  S  J-6                                                                              1 H H    H -- --                                                                              --   CH.sub.3                                        O  S  J-6                                                                              1 H H    H -- --                                                                              --   OCH.sub.3                                       -- S  J-7                                                                              0 H H    H CH.sub.3                                                                         --                                                                              --   CH.sub.3                                        -- S  J-7                                                                              0 H H    H CH.sub.3                                                                         --                                                                              --   OCH.sub.3                                       -- S  J-7                                                                              1 H H    H CH.sub.3                                                                         --                                                                              --   CH.sub.3                                        -- S  J-7                                                                              1 H H    H CH.sub.3                                                                         --                                                                              --   OCH.sub.3                                       -- S  J-8                                                                              --                                                                              H H    --                                                                              CH.sub.3                                                                         --                                                                              --   CH.sub.3                                        -- S  J-8                                                                              --                                                                              H H    --                                                                              CH.sub.3                                                                         --                                                                              --   OCH.sub.3                                       -- S  J-9                                                                              --                                                                              H H    --                                                                              CH.sub.3                                                                         --                                                                              --   CH.sub.3                                        -- S  J-9                                                                              --                                                                              H H    --                                                                              CH.sub.3                                                                         --                                                                              --   OCH.sub.3                                       O  S  J-10                                                                             --                                                                              H H    --                                                                              -- H CH.sub.3                                                                           CH.sub.3                                        O  S  J-6                                                                              --                                                                              H H    --                                                                              -- H CH.sub.3                                                                           OCH.sub.3                                       O  S  J-10                                                                             --                                                                              H H    --                                                                              -- H CH.sub.2 CH.sub.3                                                                  CH.sub.3                                        O  S  J-10                                                                             --                                                                              H H    --                                                                              -- H CH.sub.2 CH.sub.3                                                                  OCH.sub.3                                       __________________________________________________________________________

                  TABLE Vc                                                        ______________________________________                                         ##STR89##                                                                    J    W.sub.2                                                                              m'    n   R   R'.sub.1                                                                           R.sub.4                                                                            R.sub.5                                                                           R.sub.6                                                                           X.sub.3                                                                             m.p.(°C.)            ______________________________________                                        J-11 O      --    0   H   H    CH.sub.3                                                                           H   H   OCH.sub.3                         J-11 O      --    1   H   H    CH.sub.3                                                                           H   H   OCH.sub.3                         J-11 S      --    0   H   H    CH.sub.3                                                                           H   H   OCH.sub.3                         J-11 S      --    1   H   H    CH.sub.3                                                                           H   H   OCH.sub.3                         J-12 O      1     0   H   H    --   H   H   OCH.sub.3                         J-12 O      1     1   H   H    --   H   H   OCH.sub.3                         J-12 O      2     0   H   H    --   H   H   OCH.sub.3                         J-12 O      2     1   H   H    --   H   H   OCH.sub.3                         ______________________________________                                    

FORMULATIONS

Useful formulations of the compounds of Formula I can be prepared inconventional ways. They include dusts, granules, pellets, solutions,suspensions, emulsions, wettable powders, emulsifiable concentrates andthe like. Many of these may be applied directly. Sprayable formulationscan be extended in suitable media and used at spray volumes of from afew liters to several hundred liters per hectare. High strengthcompositions are primarily used as intermediates for furtherformulation. The formulations, broadly, contain about 0.1% to 99% byweight of active ingredient(s) and at least one of (a) about 0.1% to 20%surfactant(s) and (b) about 5% to 99% solid or liquid inert diluent(s).More specifically, they will contain these ingredients in the followingapproximate proportions:

                  TABLE VI                                                        ______________________________________                                                    Active  Weight Percent*                                                       Ingredient                                                                            Diluent(s)                                                                              Surfactant(s)                                   ______________________________________                                        Wettable Powders                                                                            20-90      0-74      1-10                                       Oil Suspensions,                                                                             5-50     40-95      0-15                                       Emulsions, Solutions,                                                         (including Emulsifiable                                                       Concentrates)                                                                 Aqueous Suspension                                                                          10-50     40-84      1-20                                       Dusts          1-25     70-99     0-5                                         Granules and Pellets                                                                         1-95      5-99      0-15                                       High Strength 90-99      0-10     0-2                                         Compositions                                                                  ______________________________________                                    

Lower or higher levels of active ingredient can, of course, be presentdepending on the intended use and the physical properties of thecompound. Higher ratios of surfactant to active ingredient are sometimesdesirable, and are achieved by incorporation into the formulation or bytank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook ofInsecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books,Caldwell, N.J., but other solids, either mined or manufactured, may beused. The more absorptive diluents are preferred for wettable powdersand the denser ones for dusts. Typical liquid diluents and solvents aredescribed in Marsden, "Solvents Guide," 2nd Ed., Interscience, New York,1950. Solubility under 0.1% is preferred for suspension concentrates;solution concentrates are preferably stable against phase separation at0° C. "McCutcheon's Detergents and Emulsifiers Annual", MC PublishingCorp., Ridgewood, N.J., as well as Sisely and Wood, "Encyclopedia ofSurface Active Agents", Chemical Publishing Co., Inc., New York, 1964,list surfactants and recommended uses. All formulations can containminor amounts of additives to reduce foaming, caking, corrosion,microbiological growth, etc. Preferably, ingredients should be approvedby the U.S. Environmental Protection Agency for the use intended.

The methods of making such compositions are well known. Solutions areprepared by simply mixing the ingredients. Fine solid compositions aremade by blending and, usually, grinding as in a hammer or fluid energymill. Suspensions are prepared by wet milling (see, for example,Littler, U.S. Pat. No. 3,060,084). Granules and pellets may be made byspraying the active material upon preformed granular carriers or byagglomeration techniques. See J. E. Browning, "Agglomeration", ChemicalEngineering, Dec. 4, 1967, pp. 147ff. and "Perry's Chemical Engineer'sHandbook", 4th Ed., McGraw-Hill, New York, 1963, pp. 8-59ff.

For further information regarding the art of formulation, see forexample:

H. M. Loux, U.S. Pat. No. 3,235,361, Feb. 15, 1966, Col. 6, line 16through Col. 7, line 19 and Examples 10 through 41;

R. W. Luckenbaugh, U.S. Pat. No. 3,309,192, Mar. 14, 1967, Col. 5, line43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58,132, 138-140, 162-164, 166, 167 and 169-182;

H. Gysin and E. Knusli, U.S. Pat. No. 2,891,855, June 23, 1959, Col. 3,line 66 through Col. 5, line 17 and Examples 1-4;

G. C. Klingman, "Weed Control as a Science", John Wiley and Sons, Inc.,New York, 1961, pp. 81-96; and

J. D. Fryer and S. A. Evans, "Weed Control Handbook", 5th Ed., BlackwellScientific Publications, Oxford, 1968, pp. 101-103.

In the following examples, all parts are by weight unless otherwiseindicated.

EXAMPLE 10 Wettable Powder

    ______________________________________                                        2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)                                                            50%                                                 aminocarbonyl]-2-(2-methoxyethyl)-1,2-benziso-                                thiazole-7-sulfonamide, 1,1-dioxide                                           sodium alkylnaphthalenesulfonate                                                                         2%                                                 low viscosity methyl cellulose                                                                           2%                                                 diatomaceous earth        46%                                                 ______________________________________                                    

The ingredients are blended, coarsely hammer-milled and then air-milledto produce particles essentially all below 10 microns in diameter. Theproduct is reblended before packaging.

EXAMPLE 11 Granule

    ______________________________________                                        Wettab1e Powder of Example 10                                                                         5%                                                    attapulgite granules   95%                                                    (U.S.S. 20-40 mesh; 0.84-0.42 mm)                                             ______________________________________                                    

A slurry of wettable powder containing ≈25% solids is sprayed on thesurface of attapulgite granules in a double-cone blender. The granulesare dried and packaged.

EXAMPLE 12 Extruded Pellet

    ______________________________________                                        2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)                                                            25%                                                 aminocarbonyl]-2-(2-methoxyethyl)-1,2-benziso-                                thiazole-7-sulfonamide, 1,1-dioxide                                           anhydrous sodium sulfate  10%                                                 crude calcium ligninsulfonate                                                                            5%                                                 sodium alkylnaphthalenesulfonate                                                                         1%                                                 calcium/magnesium bentonite                                                                             59%                                                 ______________________________________                                    

The ingredients are blended, hammer-milled and then moistened with about12% water. The mixture is extruded as cylinders about 3 mm diameterwhich are cut to produce pellets about 3 mm long. These may be useddirectly after drying, or the dried pellets may be crushed to pass aU.S.S. No. 20 sieve (0.84 mm openings). The granules held on a U.S.S.No. 40 sieve (0.42 mm openings) may be packaged for use and the finesrecycled.

EXAMPLE 13 Low Strength Granule

    ______________________________________                                        2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)                                                             1%                                                 aminocarbonyl]-2-(3-methylbutyl)-1,2-benziso-                                 thiazole-7-sulfonamide, 1,1-dioxide                                           N,N-dimethylformamide      9%                                                 attapulgite granules      90%                                                 (U.S.S. 20-40 sieve)                                                          ______________________________________                                    

The active ingredient is dissolved in the solvent and the solution issprayed upon dedusted granules in a double cone blender. After sprayingof the solution has been completed, the blender is allowed to run for ashort period and then the granules are packaged.

EXAMPLE 14 Aqueous Suspension

    ______________________________________                                        2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)                                                              40%                                               aminocarbonyl]-2-(2-methoxyethyl)-1,2-benziso-                                thiazole-7-sulfonamide, 1,1-dioxide                                           polyacrylic acid thickener  0.3%                                              dodecylphenol polyethylene glycol ether                                                                   0.5%                                              disodium phosphate          1%                                                monosodium phosphate        0.5%                                              polyvinyl alcohol           1.0%                                              water                       56.7%                                             ______________________________________                                    

The ingredients are blended and ground together in a sand mill toproduce particles essentially all under 5 microns in size.

EXAMPLE 15 Oil Suspension

    ______________________________________                                        2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)                                                            35%                                                 aminocarbonyl]-2-(3-methylbutyl)-1,2-benziso-                                 thiazole-7-sulfonamide, 1,1-dioxide                                           blend of polyalcohol carboxylic                                                                          6%                                                 esters and oil soluble petroleum                                              sulfonates                                                                    xylene                    59%                                                 ______________________________________                                    

The ingredients are combined and ground together in a sand mill toproduce particles essentially all below 5 microns. The product can beused directly, extended with oils, or emulsified in water.

EXAMPLE 16 Granule

    ______________________________________                                        2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)                                                            80%                                                 aminocarbonyl]-2-(2-methoxyethyl)-1,2-benziso-                                thiazole-7-sulfonamide, 1,1-dioxide                                           wetting agent              1%                                                 crude ligninsulfonate salt (containing                                                                  10%                                                 5-20% of the natural sugars)                                                  attapulgite clay           9%                                                 ______________________________________                                    

The ingredients are blended and milled to pass through a 100 meshscreen. This material is then added to a fluid bed granulator, the airflow is adjusted to gently fluidize the material, and a fine spray ofwater is sprayed onto the fluidized material. The fluidization andspraying are continued until granules of the desired size range aremade. The spraying is stopped, but fluidization is continued, optionallywith heat, until the water content is reduced to the desired level,generally less than 1%. The material is then discharged, screened to thedesired size range, generally 14-100 mesh (1410-149 microns), andpackaged for use.

EXAMPLE 17 High Strength Concentrate

    ______________________________________                                         2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)                                                             99%                                               aminocarbonyl]-2-(2-methoxyethyl)-1,2-benziso-                                thiazole-7-sulfonamide, 1,1-dioxide                                           silica aerogel              0.5%                                              synthetic amorphous silica  0.5%                                              ______________________________________                                    

The ingredients are blended and ground in a hammer-mill to produce amaterial essentially all passing a U.S.S. No. 50 screen (0.3 mmopening). The concentrate may be formulated further if necessary.

EXAMPLE 18 Wettable Powder

    ______________________________________                                        2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)                                                              90%                                               aminocarbonyl]-2-(3-methylbutyl)-1,2-benziso-                                 thiazole-7-sulfonamide, 1,1-dioxide                                           dioctyl sodium sulfosuccinate                                                                             0.1%                                              synthetic fine silica       9.9%                                              ______________________________________                                    

The ingredients are blended and ground in a hammer-mill to produceparticles essentially all below 100 microns. The material is siftedthrough a U.S.S. No. 50 screen and then packaged.

EXAMPLE 19 Wettable Powder

    ______________________________________                                        2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)                                                            40%                                                 aminocarbonyl]-2-(3-methylbutyl)-1,2-benziso-                                 thiazole-7-sulfonamide, 1,1-dioxide                                           sodium ligninsulfonate    20%                                                 montmorillonite clay      40%                                                 ______________________________________                                    

The ingredients are thoroughly blended, coarsely hammer-milled and thenair-milled to produce particles essentially all below 10 microns insize. The material is reblended and then packaged.

EXAMPLE 20 Dust

    ______________________________________                                        2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)                                                            10%                                                 aminocarbonyl]-2-(3-methylbutyl)-1,2-benziso-                                 thiazole-7-sulfonamide, 1,1-dioxide                                           attapulgite               10%                                                 talc                      80%                                                 ______________________________________                                    

The active ingredient is blended with attapulgite and then passedthrough a hammer mill to produce particles substantially all below 200microns. The ground concentrate is then blended with powdered talc untilhomogeneous.

EXAMPLE 21 Solution

    ______________________________________                                        2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)                                                            30%                                                 aminocarbonyl]-2-(3-methylbutyl)-1,2-benziso-                                 thiazole-7-sulfonamide, 1,1-dioxide                                           dimethylformamide         70%                                                 ______________________________________                                    

The ingredients are combined and stirred to produce a solution, whichcan be used for low volume applications.

Solutions of compounds of Formula I with J=J-5 to J-10 should be avoideddue to the instability of the compounds when dissolved.

Utility

The compounds of the present invention are active herbicides. They haveutility for broad-spectrum pre- and/or post-emergence weed control inareas where complete control of all vegetation is desired, such asaround fuel storage tanks, ammunition depots, industrial storage areas,oil-well sites, drive-in theaters, around billboards, highway andrailroad structures. Alternatively, the subject compounds are useful tomodify plant growth. Certain of the compounds can be used to controlweeds in crops such as wheat. The related compounds where J is J₁, n isO, R₁ =R₃ =H and R₂ is isobutyl show excellent control of wild oats bothpre- and postemergence and are also useful for preemergence andpostemergence control of grassy weeds in broadlead crops such as cottonand soybeans.

The rates of application for the compounds of the invention aredetermined by a number of factors, including their use as selective orgeneral herbicides, the crop species involved, the types of weeds to becontrolled, weather and climate, formulations selected, mode ofapplication, amount of foilage present, etc. In general terms, thesubject compounds should be applied at levels of around 0.01 to 5 kg/ha,the lower rates being suggested for use on lighter soils and/or thosehaving a low organic matter content, for selective weed control or forsituations where only short-term persistence is required.

The compounds of the invention may be used in combination with any othercommercial herbicide; examples of which are those of the triazine,triazole, uracil, urea, amide, diphenylether, carbamate and bipyridyliumtypes.

The herbicidal properties of the subject compounds were discovered in anumber of greenhouse tests. The test procedures and results follow.

Test A

Seeds of crabgrass (Digitaria sp.), barnyardgrass (Echinochloacrusgalli), wild oats (Avena fatua), sicklepod (Cassia obtusifolia),morningglory (Ipomoea sp.), cocklebur (Xanthium sp.), sorghum, corn,soybean, sugarbeet, rice, wheat and purple nutsedge (Cyperus rotundus)tubers, and in certain cases, cotton were planted and treatedpre-emergence with the test chemicals dissolved in a non-phytotoxicsolvent. At the same time, these crop and weed species, along withcotton and bush bean, were treated post-emergence with a soil/foliageapplication. At the time of treatment, the plants ranged in height from2 to 19 cm. Treated plants and controls were maintained in a greenhousefor sixteen days, after which all species were compared to controls andvisually rated for response to treatment. The ratings, summarized inTable A, are based on a numerical scale extending from 0=no injury, to10=complete kill. The accompanying descriptive symbols have thefollowing meanings:

C=chlorosis or necrosis;

E=emergence inhibition;

G=growth retardation;

H=formative effects;

L=lodging;

U=unusual pigmentation;

X=axiallary stimulation; and

6Y=abscised buds or flowers.

The data show that most of the compounds tested are highly activeherbicides with growth modifying properties and that some of thecompounds tested provide selective weed control in crops such as wheat,cotton and soybeans. It will be noted that all compounds were tested atthe low rate of 50 g/ha. It is expected that compounds such as 10, 17,19, 23, 25, 28, 34 and 35 will show improved activity at higher rates.##STR90##

    TABLE A       Compound 1 Compound 2 Compound 3 Compound 4 Compound 5 Compound 6     Compound 8 Compound 9 Compound 10 Compound 11 Compound 12 RATE G/HA 50     50 50 50 50 50 50 50 50 50 50 50       TYPE TEST POST COTTON 2C 3C 4C 9C 0 4C 4C 1C 4C 0 4C 2G  4G 8H 8G   7G     9G  6G  9H SORGHUM 3C 2C 5C 9C 3C 5C 4C 2C 3C 0 3C 4C  9G 9H 9H  7H 9H     9H 6H 9G  9G 9H CORN 2C 2C 3C 9C 2C 5C 5C 3C 3C 0 2U 4C  8H 9G 9G  2H 9H     9G 8H 9H  9G 9H SOYBEAN 2C 4C 5C 9C 0 4C 4C 0 3H 0 5C 5C  7H  9G   8G 8G        9G 9G WHEAT 5G 5G 2G 9C 0 2G 2G 0 0 0 6C 0            9G WILDOATS 4G     2C 2C 9C 2C 4C 4C 0 0 0 9C 3C   9G 5G  4G 7G 8G     8G RICE 3C 5C 9C 9C     2C 9C 9G 6G 4C 0 9C 5C  9G 9G   4G    9G   9G BARNYARDGRASS 2C 10C 5C 9C     3C 5C 6C 0 9C 0 10C 3C  9H  9H  8H 9H 9G     8H CRABGRASS 2G 5c 2C 10C     4G 6G 5C 0 3C 0 9C 2G   9G 7G    9G  6G MORNINGGLORY 2C 3C 9C 10C 1C 3C     10C 2C 3C 2G 5C 5C  3H 9G   2G 8G  3H 7H  8H 9H COCKLEBUR 3C 2C 3C 9C 0     2C 3C 2C 2C 0 4C 3C  5G 5H 8H   8G 8G 5H   8H 6H SICKLEPOD 3C 2G 5C 9C     1C 5C 9C 0 1C 0 3C 5C  5G  9G   9G     3H 9H NUTSEDGE 2G 8G 4C 9C 0 8G     4C 3G 2C 0 2C 2C    9G    9G    5G 5G SUGARBEETS 2C 9C 3C 10C 3G 2C 4C     2C 2C 0 5C 0  8G  7G   3G 9G    9G TYPE TEST PRE COTTON 0 2C 8G 2C 0 2G     8G 0 2G 0 5G 2G   8G  9G SORGHUM 0 4C 9G 10H 4G 4C 3C 2C 3C 0 3C 3C   9H        9G 9G 4G 9H  8G 9G CORN 0 4C 4U 5C 2C 2C 2C 2C 2C 0 2C 2C   9G 9H 9H     5G 7H 9G 7G 9G  9G 8G SOYBEAN 1C 4C 3C 4C 0 2C 3C 1C 2C 0 3C 2C   7G 7G     9H  5G 8G    7G 4G WHEAT 0 9C 0 10H 0 0 0 0 3G 0 0 0 WILDOATS 0 9C 2C 9C     2C 2C 9H 3G 3G 0 6C 4C    7G  5G 8H     9G 9G RICE 1C 10E 10E 10E 3c 10E     10E 8H 10E 0 9H 10E      8G      9H BARNYARDGRASS 0 4C 3C 9H 0 4H 9H 1C     3C 0 5C 4C   9H 9G      8H  6G 6G CRABGRASS 0 5C 2C 6C 0 2C 2C 2G 3G 0     4C 2G   9G 5G 9G  8G 9G    9G MORNINGGLORY 3G 9G 9G 9C 2C 6G 9G 2C 2C 0     8G 2C          9G   8G COCKLEBUR 5G 9H 8H 8H 0 5G 5G 1H 3G 0 7H 6H     SICKLEPOD 5G 2C 8G 9G 0 2G 2G 0 3G 0 2G 2C   8G          4G NUTSEDGE 0     10E 10E 10E 0 0 10E 0 9G 0 0 5G SUGARBEETS 0 9C 9G 9C 0 4G 3C 2C 3G 0 3C     0        9G    7G        Compound 13 Compound 14 Compound 15 Compound 16 Compound 17 Compound     18 Compound 19 Compound 20 Compound 21 Compound 22 Compound 23 Compound     24 RATE G/HA 50 50 50 50 50 50 50 50 50 50 50 50       TYPE TEST POST COTTON 0 8H 9H 0 0 8H 0 3C 3C 3G 0 3C         8H 9G     8H SORGHUM 2G 5C 6C 0 0 4C 0 3C 3C 0 0 2G   9G 9G   9G  8H 7H CORN 2C 4C     10C 2C 0 2C 2C 3C 3C 2C 0 3C  9H 9H  4H  5G 8H 8H 9H 7H  9H SOYBEAN 3C     5C 5C 2H 0 3C 0 5C 4C 0 0 0  9G 9G 9G   9H  9G 9G WHEAT 7G 8G 7G 0 0 3G     0 2G 0 0 0 3G WILDOATS 7G 1C 5G 0 0 0 0 0 0 0 0 0 RICE 3C 5C 5C 5G 0 4C     0 6C 5C 2G 0 6C  9G 9G 9G   8G  9G 9G   9G BARNYARDGRASS 0 3C 4C 0 0 9C     0 2C 3C 0 0 3C   9H 9H     9H 9H   9H CRABGRASS 0 2C 3C 0 0 0 0 2G 3C 0     0 2G   5G 9G      9G MORNINGGLORY 3C 4C 10C 2C 0 4C 0 5c 9C 0 0 2C  7G     9G    8G  9G    7H COCKLEBUR 3C 4C 10C 2C 0 5G 0 2C 2C 0 0 3G  9H 9H  3H        7G 6H SICKLEPOD 3C 6C 9C 0 0 2C 0 3C 2C 0 0 0  5H 9G      7G 8G     NUTSEDGE 0 2C 2C 0 0 0 0 2C 2C 0 0 5G   9G 9G     7G 8G SUGARBEETS 3H 9C     9C 2H 0 9C 0 3C 9C 3H 0 0         7H TYPE TEST PRE COTTON 0 3G 8G 0 0 0     0 0 0 0 0 0 SORGHUM 0 3C 4C 6G 0 6C 0 0 2G 0 0 3C   8G 9G   9H      9G     CORN 2C 3C 3C 4G 0 3C 0 0 2C 0 0 2C  5G 9G 9G   9H   8G   7G SOYBEAN 1C     6H 3C 1C 0 1C 0 0 2C 0 0 0    7H   3G   7G WHEAT 0 8G 4C 5G 0 6G 0 0 0 0     0 0    9G WILDOATS 0 3C 4C 0 0 6G 0 0 0 0 0 0   8G 8G RICE 2C 10E 10E 9G     0 10E 0 0 8G 0 0 9H  9H BARNYARDGRASS 0 3C 5C 0 0 3C 0 0 2H 0 0 0   7H     9H   7H CRABGRASS 0 2C 2C 0 0 1C 0 0 0 0 0 0   8G 7G MORNINGGLORY 0 8G     8H 0 0 5G 0 0 9G 0 0 2G COCKLEBUR 7G 9H 9H 0 1H 9H 0 0 4G 0 -- 0     SICKLEPOD 0 2G 7G 0 0 0 0 0 0 0 0 0 NUTSEDGE 0 8G 10E 0 0 10E 0 0 0 0 0     0 SUGARBEETS 8H 5C 5C 7G 3H 4C 0 0 8G 0 0 0   9G 9G   9G        Compound 25 Compound 26 Compound 27 Compound 28 Compound 29 Compound     30 Compound 31 Compound 32 Compound 33 Compound 34 Compound 35 Compound     36 RATE G/HA 50 50 50 50 50 50 50 50 50 50 50 50       TYPE TEST POST COTTON 0 2C 0 0 5C 1C 3C 4C 2C 0 0 0   4G   9G  8H 9G     5G SORGHUM 0 3C 3C 0 5C 2G 4C 9C 5C 0 0 4C   8H 8H  9G  9H  9H   9H CORN     0 3C 3C 0 10C 2C 5C 10C 9C 0 0 2C   8H 7H   7H 9G     9H SOYBEAN 0 0 1C0     4C 2C 5C 4C 1H 0 0 2C      9G 2H 9G 9G    4H WHEAT 0 0 0 0 9C 5G 8G 6C     1C 0 0 3C         9G 2G   9G WILDOATS 0 1C 0 0 9C 2C 5C 6C 3C 0 0 9C       4G 9G 9G 7G RICE 0 3C 3C 0 5C 1C 5C 9C 5C 0 0 5C   9G 6G  9G  9G  9G     9G BARNYARDGRASS 0 3C 3C 0 10C 2G 5C 10C 10C 0 0 9C   9H 5H    9H     CRABGRASS 0 1C 0 0 9C 0 2C 9C 9C 0 0 3C        8G     8H MORNINGGLORY 0     2C 3G 0 10C 0 3C 10C 2C 0 0 3H   5H     7H  3H COCKLEBUR 0 0 0 1H 10C 0     3C 5C 3G 0 0 3G        8H 9H SICKLEPOD -- -- -- -- -- -- -- -- -- -- --     -- NUTSEDGE 0 2C 0 0 9C 0 2C 4C 0 0 0 0   5G     9G 9G SUGARBEETS 0 0 0     0 10C 0 3C 10C 3C 0 0 3C        7H  7G   3H TYPE TEST PRE COTTON 0 0 0 0 2     C 0 2G 7G 0 0 0 0      9G SORGHUM 0 3C 0 0 9G 0 2C 9H 3C 0 0 2C   9H     7H  9H CORN 0 3C 2G 0 9G 0 2C 4C 2C 0 0 2G   8G     7H 9G 8H SOYBEAN 0     1C 0 0 3C 0 7G 4C 2C 0 0 0      8H   7G 2G WHEAT 0 0 0 0 2C 0 2G 9C 2G 0     0 5G      8G WILDOATS 0 0 0 0 2C 0 2C 9C 2C 0 0 7G      8G  7G  5G RICE     0 10E 0 0 9H 0 2C 9H 3C 0 0 0        6G  8H BARNYARDGRASS 0 3C 0 0 2C 0     0 3C 3C 0 0 2G  9H   5G   5H 8H CRABGRASS 0 3G 0 0 2C 0 5G 3C 2C 0 0 5G         7G   9G 4G MORNINGGLORY 0 2C 0 0 8G 0 3C 9C 3C 0 0 0   6H     6G  5G     COCKLEBUR -- 5G 0 0 5H 0 9H 8H 0 0 0 0 SICKLEPOD -- -- -- -- -- -- -- --     -- -- -- -- NUTSEDGE 0 5G 0 0 10E 0 0 9G 0 0 0 0 SUGARBEETS 0 2H 0 0 4C     0 2C 4C 5H 0 0 0      9G  5G 9G 5H        Compound 37 Compound 38 Compound 39 Compound 40 Compound 41 Compound     42 Compound 43 Compound 44 Compound 45 Compound 46 Compound 47 Compound     48 RATE G/HA 50 50 50 50 50 50 50 50 50 50 50 50       TYPE TEST POST COTTON 5C 5C 4C 0 0  10C 0 3C 5C 0 0 0  9H 9G 8H     8H     9G SORGHUM 9C 10C 9C 4C 4G 9C 2C 9C 9C 10C 9H 2C     8H   4H     5H CORN     10C 10C 10C 6C 3C 10C 3C 10C 10C 10C 3C 3C     9H 8H  8H    9H 7H     SOYBEAN 5C 9C 3H 1C 3G 9C 6G 3C 10C 7G 1H 0  9G  6G 3G    8H    5X WHEAT     9C 9C 4C 5C 2C 10C 6C 3C 9C 3G 2C 2G     9G 8G  9G 9G   6G WILDOATS 10C     9C 2C 4C 3C 10C 10C 10C 10C 6C 9C 5C    9G 9G 8G      9H 9G RICE 9C 9C     9C 4C 3C 9C 9C 9C 9C 9C 4C 8G     9G 9G BARNYARDGRASS 10C 9C 10C 4C 3C     10C 4C 9C 9C 9C 3C 0     8H 5H  9H CRABGRASS 9C 10C 7C 0 0 10C 3C 9C 10C     9C 0 0    9H    8G MORNINGGLORY 10C 10C 2C 0 0 10C 0 4C 10C 2C 0 0    7G         8H  5H COCKLEBUR 5C 9C 4C 2G 0 10C 0 4C 10C 2C 2G 1H  9H  8H     9H     7G SICKLEPOD -- -- -- -- -- -- -- -- -- -- -- -- NUTSEDGE 4C 9C 2C 3G 0     10C 0 3C 9C 2C 0 0  9G  5G     8G  3G SUGARBEETS 10C 10C 5C 2C 0 10C 4H     3C 9C 4H 3H 0    9H 5H    8H TYPE TEST PRE COTTON 5G 8G 0 0 0 9G 0 5G 9G 0      0 0 SORGHUM 5C 5C 9C 2C 0 7C 4G 4C 9H 3C 0 0  9H 9H  3G  9H  9H  9H     CORN 5C 10H 5C 2C 0 10E 3G 3C 9G 2C 2C 0  9H  9H 5G    9G  8G 4G SOYBEAN     3C 4C 3C 0 0 9H 0 2C 2C 0 0 0  7G 8H 4G     4H 7G WHEAT 7C 9C 6G 7G 0 9H     0 2G 8G 3G 0 0  9H WILDOATS 9C 10C 2C 3G 0 9C 2C 9C 9C 7G 2G 0    5G     6G RICE 5C 10H 5C 2C 0 10E 2C 10E 10E 10E 2G 0  9H  9H 3G   7G BARNYARDGR     ASS 3C 9C 2C 1C 0 4C 1H 3C 4C 3C 2H 0  7H  8H   9H  9H 9H 9H CRABGRASS     10H 10H 3C 0 0 10C 0 4C 10C 3C 0 0    7G     9H  9G MORNINGGLORY 3C 5C     3C 2C 0 10C 0 3C 9G 3G 0 0  7H 9G 7H 4H    6H COCKLEBUR 9H 4C 2H -- 0 9H     0 -- 8H 2G 0 0   9H SICKLEPOD -- -- -- -- -- -- -- -- --  -- -- --     NUTSEDGE 10E 10E 4G 0 0 10E 0 3C 10E 10E 0 0         5G SUGARBEETS 6C 6C     2C 3H 0 10C 0 4C 5C 5G 0 0  9G 9G 5H     9H 9G        Compound 49 Compound 50 Compound 51 Compound 52 Compound 53 Compound     54 RATE G/HA 50 50 50 50 50 50       TYPE TEST POST COTTON 4G 9H 9C 9H 0 0 SORGHUM 4C 6C 9C 9C 3C 2C  8H 9G       8H 3H CORN 5C 9C 10C 9C 3C 3C  9H    8H 9H SOYBEAN 2H 4C 4C 6H 0 0  5G     9G 9G WHEAT 4C 9C 5C 2C 2c 2G  9G  9G 6G 6G WILDOATS 5C 9C 9C 3C 2C 2C     9G   7G 5G 5G RICE 5C 9C 6C 9C 2C 9G  9G  9G  9G BARNYARDGRASS 3C 9C 9C     10C 6H 4H  6H CRABGRASS 5G 5C 10C 9C 0 0   9G MORNINGGLORY 3C 5C 10C 10C     0 0  8H 9G COCKLEBUR 4G 4C 10C 8H 1H 0   9H SICKLEPOD -- -- -- -- -- --     NUTSEDGE 2c 4C 9C 3C 0 0  8G 9G  8G SUGARBEETS 3C 10C 9C 10C 1H 0  7H     TYPE TEST PRE COTTON 0 3G 9G 6G 0 0 SORGHUM 2G 4C 6C 9C 2G 0   9H 9H     CORN 5G 9G 5C 3C 6G 2G    9H 9H SOYBEAN 0 3C 3C 2C 0 1C   7G 8G 5G WHEAT     7G 9G 6C 3C 5G 0    9H 7G WILDOATS 3C 9C 7C 3C 2G 2C  9G  9H 8G  3G RICE     8H 5C 10E 10E 3G 3G   9H BARNYARDGRASS 0 5C 7C 6C 0 0   9H 9H 9H     CRABGRASS 0 5C 7C 3C 0 0   9G 9H 7G MORNINGGLORY 3C 9H 9C 8H 0 0     COCKLEBUR 0 -- 9H 5H 0 0 SICKLEPOD -- -- -- -- -- -- NUTSEDGE 0 9G 10E     3C 0 0     9H SUGARBEETS 0 9G 9C 5C 2G 4G     9G

TEST B

Two ten-inch in diameter plastic pans lined with polyethylene linerswere filled with prepared Fallsington slit loam soil. One pan wasplanted with seeds of wheat (Triticum aestivum), barley (Hordeumvulgare), wild oats (Amena fatua), cheatgrass (Bromus secalinus),blackgrass (Alopecurus myosuroides) annual bluegrass (Poa annua), greenfoxtail (Setaria viridis), rapeseed (Brassica napus), and Italianryegrass (Lolium multiflorum). The other pan was planted with seeds ofRussian thistle (Salsola kali), speedwell (Veronica persica), kochia(Kochia scoparia), shepherd's purse (Capsella bursa-pastoris),Matricaria inodora, black nightshade (Solanum nigrum), and wildbuckwheat (Polygonum convolvulus). The above two pans were treatedpreemergence. At the same time two pans in which the above plant specieswere growing were treated post-emergence. Plant height at the time oftreatment ranged from 1-15 cm depending on plant species.

The compounds applied were diluted with a nonphytotoxic solvent andsprayed over-the-top of the pans. An untreated control and a solventalone control were included for comparison. All treatments weremaintained in the greenhouse for 20 days at which time the treatmentswere compared to the controls and the effects visually rated. Therecorded data are presented in Table B.

                                      TABLE B                                     __________________________________________________________________________    TYPE                                                                              RATE     BAR- WILD-                                                                              CHEAT-                                                                             BLACK-                                                                             BLUE-                                                                              FOX- RYE- CIAB-                                                                              RAPE-                    TEST                                                                              G/HA                                                                              WHEAT                                                                              LEY  OATS GRASS                                                                              GRASS                                                                              GRASS                                                                              TAIL GRASS                                                                              GRASS                                                                              SEED                     __________________________________________________________________________            Compound 2                                                            POST                                                                              125 10C  10C  10C  9G   10C  10C  10C  10C  10C                           PRE 125 8G   9G   9G   10C  9G   8G   10C  10C  9G                            POST                                                                              64  8G   10C  10C  8G   10C  10C  10C  10C  10C                           PRE 64  7G   7G   9G   9G   9G   9G   9G   8G   5G                            POST                                                                              32  3G   10C  7C   7G   9G   10C  10C  7G   10C                           PRE 32  6G   6G   8G   8G   7G   7G   7G   7G   0                             POST                                                                              16  0    10C  10C  7G   9G   10C  10C  6G   9G                            PRE 16  4G   4G   6G   7G   4G   7G   2g   4G   0                             POST                                                                              8   0    9G   8G   0    3G   4G   9G   4G   9G                            PRE 8   0    2G   4G   3G   4G   4G   0    2G   0                             __________________________________________________________________________            MATRI-                                                                        CARIA                                                                 TYPE                                                                              RATE                                                                              INO-             SHEPARDS-    NIGHT-                                                                             SPEED-                                                                             BUCK-                                                                              SUGAR-                   TEST                                                                              G/HA                                                                              DORA GALIUM                                                                              THISTLE                                                                             PURSE  KOCHIA                                                                              SHADE                                                                              WELL WHEAT                                                                              BEETS                    __________________________________________________________________________            Compound 2                                                            POST                                                                              125 6G   10C   10C   9G     8G    10C  0    7G   9G                       PRE 125 8G   10C   0     9G     9G    8G   0    9G   10C                      POST                                                                              64  5G   10C   10C   8G     8G    8G   0    7G   9G                       PRE 64  7G   9G    0     9G     6G    8G   0    9G   10C                      POST                                                                              32  2G   7G    10C   9G     5G    6G   0    0    9G                       PRE 32  7G   7G    0     9G     0     7G   0    5G   9G                       POST                                                                              16  0    5G    10C   9G     0     0    0    0    9G                       PRE 16  6G   6G    0     7G     0     5G   0    0    5G                       POST                                                                              8   0    4G    7G    8g     0     0    0    0    3G                       PRE 8   3G   4G    0     6G     0     2G   0    0    4G                       __________________________________________________________________________    TYPE                                                                              RATE     BAR- WILD-                                                                              CHEAT-                                                                             BLACK-                                                                             BLUE-                                                                              FOX- RYE- CIAB-                                                                              RAPE-                    TEST                                                                              G/HA                                                                              WHEAT                                                                              LEY  OATS GRASS                                                                              GRASS                                                                              GRASS                                                                              TAIL GRASS                                                                              GRASS                                                                              SEED                     __________________________________________________________________________            Compound 3                                                            POST                                                                              125 0    0    0    0    5G   3G    7G  0    10C                           PRE 125 0    0    0    0    0    0    0    0    0                             POST                                                                              64  0    0    0    0    4G   0    6G   0    8G                            PRE 64  0    0    0    0    0    0    0    0    0                             POST                                                                              32  0    0    0    0    0    0    0    0    7G                            PRE 32  0    0    0    0    0    0    0    0    0                             POST                                                                              16  0    0    0    0    0    0    0    0    4G                            PRE 16  0    0    0    0    0    0    0    0    0                             POST                                                                              8   0    0    0    0    0    0    0    0    2G                            PRE 8   0    0    0    0    0    0    0    0    0                             __________________________________________________________________________            MATRI-                                                                        CARIA                                                                 TYPE                                                                              RATE                                                                              INO-             SHEPARDS-    NIGHT-                                                                             SPEED-                                                                             BUCK-                                                                              SUGAR                    TEST                                                                              G/HA                                                                              DORA GALIUM                                                                              THISTLE                                                                             PURSE  KOCHIA                                                                              SHADE                                                                              WELL WHEAT                                                                              BEETS                    __________________________________________________________________________            Compound 3                                                            POST                                                                              125 5G   10C   10C   7G     10C   0    0    6G   0                        PRE 125 7G   8G    4G    9G     7G    8G   0    0    4G                       POST                                                                              64  0    6G    9G    7G     3G    0    0    0    0                        PRE 64  7G   2G    4G    6G     7G    6G   0    0    0                        POST                                                                              32  0    4G    8G    6G     0     0    0    0    0                        PRE 32  6G   2G    3G    4G     5G    4G   0    0    0                        POST                                                                              16  0    0     7G    6G     0     0    0    0    0                        PRE 16  4G   0     0     3G     0     0    0    0    0                        POST                                                                              8   0    0     3G    5G     0     0    0    0    0                        PRE 8   0    0     0     0      0     0    0    0    0                        __________________________________________________________________________

What is claimed is:
 1. A compound of the formula: ##STR91## wherein J is##STR92## n is 0 or 1; W is O or S;W₁ is S; W₂ is O or S; R is H or CH₃; R₁ is H, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, halogen, nitro, C₁ -C₆alkoxy, SO₂ NR_(a) R_(b), C₁ -C₆ alkylthio, C₁ -C₆ alkylsulfinyl, C₁ -C₆alkylsulfonyl, CN, CO₂ R_(c), C₁ -C₆ haloalkoxy, C₁ -C₆ haloalkylthio,NH₂, C₁ -C₆ alkylamino, di(C₁ -C₆ alkyl)amino, Si(CH₃)₂ (C₁ -C₄ alkyl),Si(CH₃)₂ -phenyl or C₁ -C₃ alkyl substituted with C₁ -C₃ alkoxy, C₁ -C₃alkylthio, C₁ -C₃ alkylsulfinyl, C₁ -C₃ alkylsulfonyl, SO₂ NR_(d) R_(e),NO₂, CN, CO₂ R_(f), C₁ -C₃ haloalkoxy or C₁ -C₃ haloalkylthio; R_(a) isH, C₁ -C₄ alkyl, C₁ -C₃ cyanoalkyl, methoxy or ethoxy; R_(b) is H, C₁-C₄ alkyl or C₃ -C₄ alkenyl; or R_(a) and R_(b) may be taken together as--(CH₂)₃ --, --(CH₂)₄ --, --(CH₂)₅ -- or --CH₂ CH₂ OCH₂ CH₂ --; R_(c) isC₁ -C₄ alkyl, C₃ -C₄ alkenyl, C₃ -C₄ alkynyl, C₂ -C₄ haloalkyl, C₂ -C₃cyanoalkyl, C₅ -C₆ cycloalkyl, C₄ -C₇ cycloalkylalkyl or C₂ -C₄alkoxyalkyl; R_(d) is C₁ -C₃ alkyl; R_(e) is H or C₁ -C₃ alkyl; R_(f) isC₁ -C₃ alkyl; R₁ ' is H, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, C₁ -C₃ haloalkoxy,C₁ -C₃ haloalkyl, C₁ -C₃ alkylthio, C₁ -C₃ haloalkylthio, amino, C₁ -C₃alkylamino, di(C₁ -C₃ alkyl)amino, halogen or NO₂ ; R₂ is H, R₁₁ ', SR₁₁', SO₂ R₁₁, OR₁₁ ', C(O)R₁₁, C(O)OR₁₁ ', (C(O))₂ OR₁₁ ', (CO)₂ R₁₁,C(O)NR₁₂ R₁₈, C(O)NRA, C(S)SR₁₁, NH₂, NR₁₂ R₁₈, OH, CN, P(O)R₁₃ R₁₄,P(S)R₁₃ R₁₄, Si(CH₃)₂ R₁₅, L or C(O)L; R₃ is H or CH₃ ; R₄ is C₁ -C₄alkyl; R₅ is H or C₁ -C₄ alkyl; R₆ is H or CH₃ ; R₇ is C₁ -C₄ alkyl, Clor Br; A is ##STR93## X is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄haloalkoxy, C₁ -C₄ haloalkyl, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, F,Cl, Br, C₂ -C₅ alkoxyalkyl, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃alkylamino, amino, di(C₁ -C₃ alkyl)amino or C₃ -C₅ cycloalkyl; Y is H,C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkylthhio,C₁ -C₄ alkylthio, C₂ -C₅ alkoxyalkyl, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃alkylamino, di(C₁ -C₃ alkyl)amino, C₃ -C₄ alkenyloxy, C₃ -C₄ alkynyloxy,C₂ -C₅ alkylthioalkyl, C₁ -C₄ haloalkyl, azido, cyano, ##STR94## orN(OCH₃)CH₃ ; m is 2 or 3; Q₁ and Q₂ are independently O or S; R₈ is H orC₁ -C₃ alkyl; R₉ and R₁₀ are independently C₁ -C₃ alkyl; Z is CH, CCH₃,CC₂ H₅, CCl or CBr; R₁₁ is C₁ -C₁₀ alkyl, C₃ -C₁₀ alkoxyalkoxyalkyl, C₂-C₁₀ alkenyl, C₄ -C₁₀ alkenylalkenyl, C₃ -C₁₀ epoxyalkyl, C₂ -C₁₀alkynyl, C₄ -C₁₀ alkynylalkynyl, C₄ -C₁₀ alkynylalkenyl, C₃ -C₆cycloalkyl, C₄ -C₇ cycloalkylalkyl or ##STR95## when R₁₁ is C₃ -C₆cycloalkyl or C₄ -C₇ cycloalkylalkyl it may optionally be substituted byC₁ -C₄ alkyl, 1 to 3 atoms of Cl or F or 1 Br; when R₁₁ is C₁ -C₁₀alkyl, C₂ -C₁₀ alkenyl or C₂ -C₁₀ alkynyl it may optionally besubstituted by one or more halogens and/or by (R₁₇)_(m'), where m' is 2,the values of R₁₇ may be identical or different; R₁₁ ' is C₁ -C₁₀ alkyl,C₃ -C₁₀ alkoxyalkoxyalkyl, C₃ -C₁₀ alkenyl, C₅ -C₁₀ alkenylalkenyl, C₃-C₁₀ epoxyalkyl, C₃ -C₁₀ alkynyl, C₅ -C₁₀ alkynylalkynyl, C₅ -C₁₀alkynylalkenyl, C₃ -C₆ cycloalkyl, C₄ -C₇ cycloalkylalkyl or ##STR96##when R₁₁ ' is C₃ -C₆ cycloalkyl or C₄ -C₇ cycloalkylalkyl it may beoptionally substituted by C₁ -C₄ alkyl, 1 to 3 atoms of Cl or F or 1 Br;when R₁₁ ' is C₁ -C₁₀ alkyl, C₃ -C₁₀ alkenyl or C₃ -C₁₀ alkynyl, it mayoptionally be substituted by one or more halogens and/or by (R₁₇)_(m'),where when m' is 2, the values of R₁₇ may be identical or different; m'is 1 or 2; R₁₂ is H or C₁ -C₄ alkyl; R₁₃ and R₁₄ are independently C₁-C₄ alkyl, C₁ -C₄ alkoxy or C₁ -C₄ alkylthio; R₁₅ is C₁ -C₁₀ alkyl,benzyl or ##STR97## R₁₆ is H, F, Cl, Br, CH₃, OCH₃, NO₂, CN, SCH₃, SO₂CH₃ or CF₃ ; R₁₇ is OR₁₈, OC(O)R₁₈, P⁺ R₉ R₁₀ R₁₅, P⁺ (C₆ H₅)₃,OC(O)NR₁₂ R₁₈, OSO₂ R₁₈ ', OP(O)R₁₃ R₁₄, P(O)R₁₃ R₁₄ OP(S)R₁₃ R₁₄,P(S)R₁₃ R₁₄, OSi(CH₃)₂ R₁₅, Si(CH₃)₂ R₁₅, SR₁₉, SOR₁₉ ', SO₂ R₁₈ ', SCN,CN, SP(O)R₁₃ R₁₄, SP(S)R₁₃ R₁₄, N⁺ R₁₂ R₁₅ R₁₈, NR₁₂ R₁₈, NR₁₂ C(O)R₁₈,NR₁₂ C(O)OR₁₈ ', NR₁₂ C(O)NR₁₂ R₁₈, NR₁₂ SO₂ R₁₈ ', NR₁₂ P(O)R₁₃ R₁₄,NR₁₂ P(S)R₁₃ R₁₄, NO₂, C(O)R₁₈, C(O)OR₁₈, C(O)NR₁₂ R₁₈, SeR₁₈, naphthyl,L, ##STR98## R₁₈ is H, C₁ -C₁₀ alkyl, C₁ -C₁₀ haloalkyl, C₂ -C₁₀alkenyl, C₂ -C₁₀ alkynyl, C₃ -C₆ cycloalkyl or ##STR99## R₁₈ ' is C₁-C₁₀ alkyl, C₁ -C₁₀ haloalkyl, C₃ -C₁₀ alkenyl, C₃ -C₁₀ alkynyl, C₃ -C₆cycloalkyl or ##STR100## R₁₉ is H, F, Cl, Br, CH₃, ##STR101## and L ispyridinyl, thienyl, furanyl, 4,5-dihydrofuranyl, pyrrolyl, oxazolyl,4,5-dihydrooxazolyl, thiazolyl, isoxazolyl, oxadiazolyl, pyrazolyl,triazolyl, imidazolyl, 4,5-dihydroimidazolyl, thiadiazolyl, morpholinyl,triazinyl, 1,3-dioxolanyl, tetrahydropyranyl or pyrimidinyl, and theseheterocycles may optionally be substituted by 1-4 CH₃, 1-2 OCH₃, SCH₃,Cl, N(CH₃)₂ or CN or L is a 5- or 6-membered lactone, lactam orcycloalkanone which may optionally be substituted by 1-4 CH₃groups;provided that (a) when W is S, then R is H, J is J₁, J₂, J₃ or J₄; A is A-1, Z is CH, and Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, CF₃,SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CF₃, OCH₂ CH₂ OCH₃, CH(OCH₃)₂ or##STR102## (b) when X is F, Cl or Br, then Z is CH and Y is OCH₃, OC₂H₅, NH₂, NHCH₃, N(CH₃)₂ or OCF₂ H; (c) when R₃ is CH₃, then n is O; (d)when J is J-1 or J-2 and R₂ is H or C₁ -C₄ alkyl, then R₁ and R₁ ' areother than H, F, Cl, Br, CH₃, OCH₃, CF₃, OCF₂ H, or SCH₃ or X is otherthan CH₃, OCH₃, OCH₂ CH₃, F, Cl, Br, OCF₂ H, CH₂ Cl, CH₂ Br, CH₂ F,cyclopropyl or CF₃ or Y is C₃ -C₄ alkyl, C₃ -C₄ alkoxy, C₄ haloalkoxy,C₄ haloalkylthio, C₃ -C₅ alkoxyalkyl, C₄ -C₅ alkoxyalkoxy, C₂ -C₃alkylamino, di(C₂ -C₃ alkyl)amino, C₄ alkenyloxy, C₄ alkynyloxy, C₃ -C₅alkylthioalkyl, C₂ -C₄ haloalkyl, C₂ -C₄ alkynyl, C(O)R₈ or N(OCH₃)CH₃ ;(e) the total number of carbon atoms in R₂ does not exceed 13; (f) whenX is C₃ -C₅ cycloalkyl, then Y is CH₃, CH₂ CH₃, OCH₃, OCH₂ CH₃, CH₂OCH₃, OCF₂ H, SCF₂ H, OCH₂ CF₃, CF₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, NHCH₃,N(CH₃)₂ or CH(OCH₃)₂ ; (g) when R₁ or R₁ ' is para to the sulfonylureabridge than R₁ or R₁ ' are H, CH₃, F, Cl, Br or OCH₃ ; and (h) when X orY is OCH₂ CH₂ F or OCH₂ CHF₂ then R₂ is other than C₅ alkyl, CH₃ OCH₂CH₂, C₂ H₅ OCH₂ CH₂ or C₁ -C₄ alkyl substituted with 1-3 atoms of F, Clor Br; (i) when X or Y is OCH₂ CH₂ F, OCH₂ CHF₂ or OCH₂ CF₃, then theother is not di(C₁ -C₃ alkyl)amino C₁ -C₃ alkylamino or N(OCH₃)CH₃ ; (j)when X or Y is OCF₂ H, then Z is CH; and (k) when R₁₇ and the bridgingnitrogen of a cyclic sulfonamide are attached to the same carbon, thenR₁₇ is other than OH, SH, OC(O)R₁₈, OC(O)NR₁₂ R₁₈, OSO₂ R₁₈ ', OP(O)R₁₃R₁₄, OSi(CH₃)₂ R₁₅, SP(O)R₁₃ R₁₄, SP(S)R₁₃ R₁₄, NR₁₂ R₁₈ or N⁺ R₁₂ R₁₅R₁₈ ;and their agriculturally suitable salts.
 2. Compounds of claim 1wherein J is J-1 or J-4.
 3. Compounds of claim 1 wherein J is J-2 orJ-3.
 4. Compounds of claim 1 wherein J is J-8 or J-9.
 5. Compounds ofclaim 1 wherein J is J-5, J-6, J-7 or J-10.
 6. Compounds of claim 1wherein J is J-11 or J-12.
 7. Compounds of claim 2 whereinW is O; R isH; X is CH₃, OCH₃, OCH₂ CH₃, Cl, F, Br, OCF₂ H, CH₂ F, CF₃ orcyclopropyl; Y is H, CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, NH₂, NHCH₃,N(OCH₃)CH₃, N(CH₃)₂, C₂ H₅, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂CF₃, CN, N₃, OCH₂ CH₂ OCH₃, CH₂ SCH₃, ##STR103## or QCF₂ T; Q is O or S;T is H, CHClF, CHBrF or CHFCF₃.
 8. Compounds of claim 7 whereinR₁ is C₁-C₃ alkyl, C₁ -C₃ alkoxy, C₁ -C₃ haloalkoxy, C₁ -C₃ haloalkyl, C₁ -C₃alkylthio, C₁ -C₃ haloalkylthio, amino, C₁ -C₃ alkylsulfinyl, C₁ -C₃alkylsulfonyl, CN, NH₂, C₁ -C₃ alkylamino, di(C₁ -C₃ alkylamino) or C₁-C₂ alkyl substituted with C₁ -C₂ alkoxy, C₁ -C₂ alkylthio, C₁ -C₂haloalkoxy, C₁ -C₂ haloalkylthio, CN, HCl or NO₂.
 9. Compounds of claim8 whereinR₂ is C₁ -C₆ alkyl, C₁ -C₆ alkylcarbonyl, C₁ -C₆alkoxycarbonyl, C₁ -C₆ alkyl substituted by 1-3 atoms of F, Cl or 1 Br,or by 1 or 2 groups selected from C₁ -C₂ alkoxy, CN, C₁ -C₂alkoxycarbonyl, C₁ -C₂ alkylcarbonyl, OH, C₁ -C₂ alkylthio, C₁ -C₂alkylsulfonyl, C₁ -C₂ alkylsulfonyloxy or C₁ -C₂ alkylcarbonyloxy, C₃-C₄ alkenyl, C₃ -C₄ haloalkenyl, C₃ -C₄ alkynyl, C₄ alkynyl substitutedby 1 atom of F or Cl, phenyl or phenyl substituted with Cl, CF₃, NO₂, CNor SO₂ CH₃ ; and R₄ is CH₃.
 10. Compounds of claim 9 whereinA is A-1;and Y is CH₃, C₂ H₅, OCH₃, CH₂ OCH₃, OCF₂ H or CH(OCH₃)₂.
 11. Compoundsof claim 10 wherein R₁ and R₁ ' are H, Cl, C₁ -C₂ alkyl, C₁ -C₂ alkoxyor C₁ -C₂ alkylthio.
 12. Compounds of claim 11 wherein J is J-1. 13.Compounds of claim 12 whereinR₁ is H; and Z is CH.
 14. Compounds ofclaim 13 whereinR₂ is C₁ -C₄ haloalkyl, C₁ -C₃ alkyl substituted with C₁-C₂ alkoxy, C₁ -C₂ alkylthio, C₁ -C₂ alkylsulfonyl or CN, C₃ -C₄alkenyl, C₃ -C₄ haloalkenyl, C₃ -C₄ alkynyl, C₁ -C₃ alkoxycarbonyl or C₁-C₃ alkylcarbonyl.
 15. Compounds of claim 3 whereinW is O; R₁ is H; X isCH₃, OCH₃, OCH₂ CH₃, Cl, F, Br, OCF₂ H, CH₂ F, CF₃ or cyclopropyl; Y isH, CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, NH₂, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂, C₂ H₅,CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CF₃, CN, N₃, OCH₂ CH₂ OCH₃,CH₂ SCH₃, ##STR104## or QCF₂ T; R₂ is C₁ -C₆ alkyl, C₁ -C₆alkylcarbonyl, C₁ -C₆ alkoxycarbonyl, C₁ -C₆ alkyl substituted by 1-3atoms of F, Cl or 1 Br, or by 1 or 2 groups selected from C₁ -C₂ alkoxy,CN, C₁ -C₂ alkoxycarbonyl, C₁ -C₂ alkylcarbonyl, OH, C₁ -C₂ alkylthio,C₁ -C₂ alkylsulfonyl, C₁ -C₂ alkylsulfonyloxy or C₁ -C₂alkylcarbonyloxy, C₃ -C₄ alkenyl, C₃ -C₄ haloalkenyl, C₃ -C₄ alkynyl, C₄alkynyl substituted by 1 atom of F or Cl, phenyl or phenyl substitutedwith Cl, CF₃, NO₂, CN or SO₂ CH₃ ; R₁ ' is H, Cl, C₁ -C₂ alkyl, C₁ -C₂alkoxy or C₁ -C₂ alkylthio.
 16. Compounds of claim 15 whereinA is A-1;and Y is CH₃, C₂ H₅, OCH₃, CH₂ OCH₃, OCF₂ H or CH(OCH₃)₂.
 17. Compoundsof claim 4 wherein W is O; R₁ ' is H; R₁ is H; A is A-1; X is CH₃, OCH₃,OCH₂ CH₃, Cl, F, Br, OCF₂ H, CH₂ F or cyclopropyl; and Y is CH₃, C₂ H₅,OCH₃, CH₂ OCH₃, OCF₂ H or CH(OCH₃)₂.
 18. Compounds of claim 5 whereinWis O; R₁ is H; R₁ ' is H; A is A-1; X is CH₃, OCH₃, OCH₂ CH₃, Cl, F, Br,OCF₂ H, CH₂ F or cyclopropyl; and Y is CH₃, C₂ H₅, OCH₃, CH₂ OCH₃, OCF₂H or CH(OCH₃)₂.
 19. Compounds of claim 6 wherein W is O; R₁ ' is H; R₁is H; A is A-1; X is CH₃, OCH₃, OCH₂ CH₃, Cl, F, Br, OCF₂ H, CH₂ F orcyclopropyl; and Y is CH₃, C₂ H₅, OCH₃, CH₂ OCH₃, OCF₂ H or CH(OCH₃)₂.20. The compound of claim 1 which is2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(2-methoxyethyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide.
 21. The compound of claim 1 which is2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(3-methylbutyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide.
 22. The compound of claim 1 which is2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(phenylmethyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide.
 23. The compound of claim 1 which is2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(2-oxopropyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide.
 24. The compound of claim 1 which is2,3-dihydro-N-[(4-chloro-6-methoxypyrimidin-2-yl)aminocarbonyl]-2-(2-ethoxyethyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide.
 25. The compound of claim 1 which is2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(2-ethoxyethyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide.
 26. The compound of claim 1 which is2,3-dihydro-N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-2-(2-fluoroethyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide.
 27. The compound of claim 1 which is2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-acetyl-1,2-benzoisothiazole-7-sulfonamide,1,1-dioxide.
 28. The compound of claim 1 which is2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(3-chloropropyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide.
 29. The compound of claim 1 which is2,3-dihydro-N-[(chloro-6-methoxypyrimidin-2-yl)aminocarbonyl]-2-(2-fluoroethyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide.
 30. The compound of claim 1 which is2,3-dihydro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(3-fluoropropyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide.
 31. The compound of claim 1 which is2,3-dihydro-N-[(4-chloro-6-methoxypyrimidin-2-yl)aminocarbonyl]-2-(2-chloroethyl)-1,2-benzisothiazole-7-sulfonamide,1,1-dioxide.
 32. The compound of claim 1 which isN-[(4-chloro-6-methoxypyrimidin-2-yl)aminocarbonyl]-2-(2-fluoroethyl)-2,3-dihydro-1,2-benzoisothiazole-7-sulfonamide,1,1-dioxide.
 33. The compound of claim 1 which isN-[(4-chloro-6-methoxypyrimidin-2-yl)aminocarbonyl]-2-(3-fluoropropyl)-2,3-dihydro-1,2-benzoisothiazole-7-sulfonamide,1,1-dioxide.
 34. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 1 and at least one of the following: surfactant, solid orliquid diluent.
 35. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 2 and at least one of the following: surfactant, solid orliquid diluent.
 36. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 3 and at least one of the following: surfactant, solid orliquid diluent.
 37. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 4 and at least one of the following: surfactant, solid orliquid diluent.
 38. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 5 and at least one of the following: surfactant, solid orliquid diluent.
 39. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 6 and at least one of the following: surfactant, solid orliquid diluent.
 40. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 7 and at least one of the following: surfactant, solid orliquid diluent.
 41. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 8 and at least one of the following: surfactant, solid orliquid diluent.
 42. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 9 and at least one of the following: surfactant, solid orliquid diluent.
 43. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 10 and at least one of the following: surfactant, solid orliquid diluent.
 44. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 11 and at least one of the following: surfactant, solid orliquid diluent.
 45. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 12 and at least one of the following: surfactant, solid orliquid diluent.
 46. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 13 and at least one of the following: surfactant, solid orliquid diluent.
 47. A method for controlling the growth of undesiredvegetation which comprises applying to the locus to be protected aneffective amount of a compound of claim
 1. 48. A method for controllingthe growth of undesired vegetation which comprises applying to the locusto be protected an effective amount of a compound of claim
 2. 49. Amethod for controlling the growth of undesired vegetation whichcomprises applying to the locus to be protected an effective amount of acompound of claim
 3. 50. A method for controlling the growth ofundesired vegetation which comprises applying to the locus to beprotected an effective amount of a compound of claim
 4. 51. A method forcontrolling the growth of undesired vegetation which comprises applyingto the locus to be protected an effective amount of a compound of claim5.
 52. A method for controlling the growth of undesired vegetation whichcomprises applying to the locus to be protected an effective amount of acompound of claim
 6. 53. A method for controlling the growth ofundesired vegetation which comprises applying to the locus to beprotected an effective amount of a compound of claim
 7. 54. A method forcontrolling the growth of undesired vegetation which comprises applyingto the locus to be protected an effective amount of a compound of claim8.
 55. A method for controlling the growth of undesired vegetation whichcomprises applying to the locus to be protected an effective amount of acompound of claim
 9. 56. A method for controlling the growth ofundesired vegetation which comprises applying to the locus to beprotected an effective amount of a compound of claim
 10. 57. A methodfor controlling the growth of undesired vegetation which comprisesapplying to the locus to be protected an effective amount of a compoundof claim
 11. 58. A method for controlling the growth of undesiredvegetation which comprises applying to the locus to be protected aneffective amount of a compound of claim
 12. 59. A method for controllingthe growth of undesired vegetation which comprises applying to the locusto be protected an effective amount of a compound of claim 13.